Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Analysis of a mechanism, mediators and sequence of events in the context of an assessment of stimulatory effect of senescence of human peritoneal mesothelium on the development of the intraperitoneal cancer metastases

2011/03/B/NZ3/01214

Keywords:

cancer metastases cellular senescence colorectal cancer peritoneal cavity ovarian cancer pancreatic cancer

Descriptors:

  • NZ3_4: Ageing
  • NZ3_1: Cell biology
  • NZ3_14: Other related subjects

Panel:

NZ3 - Cellular and developmental biology: cell biology, developmental biology, ageing biology, neurobiology

Host institution :

Uniwersytet Medyczny im. Karola Marcinkowskiego w Poznaniu, Wydział Lekarski II

woj. wielkopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr hab. Krzysztof Książek 

Number of co-investigators in the project: 7

Call: OPUS 2 - announced on 2011-09-15

Amount awarded: 857 520 PLN

Project start date (Y-m-d): 2012-08-30

Project end date (Y-m-d): 2015-08-29

Project duration:: 36 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. komora z laminarnym przepływem powietrza (40 000 PLN)
  2. mikroskop świetlny.
  3. stacja wymiany klatek (50 000 PLN)

Information in the final report

  • Publication in academic press/journals (6)
  • Articles in post-conference publications (7)
  1. Starzenie się komórek mezotelialnych
    Authors:
    Mikuła-Pietrasik J, Ksiazek K.
    Academic press:
    Postępy Biochemii (rok: 2014, tom: 60, strony: 187-193), Wydawca: Polskie Towarzystwo Biochemiczne
    Status:
    Published
    DOI:
    brak - link to the publication
  2. Senescent peritoneal mesothelium induces a pro-angiogenic phenotype in ovarian cancer cells in vitro and in a mouse xenograft model in vivo
    Authors:
    Mikuła-Pietrasik J, Sosińska P, Naumowicz E, Maksin K, Piotrowska H, Woźniak A, Szpurek D, Książek K.
    Academic press:
    Clinical & Experimental Metastasis (rok: 2015, tom: ., strony: 45304), Wydawca: Springer
    Status:
    Accepted for publication
    DOI:
    10.1007/s10585-015-9753-y - link to the publication
  3. Bystander senescence in human peritoneal mesothelium and fibroblasts is related to thrombospondin-1-dependent activation of transforming growth factor-β1
    Authors:
    Mikuła-Pietrasik J, Sosińska P, Janus J, Rubiś B, Brewińska-Olchowik M, Piwocka K, Książek K.
    Academic press:
    Int J Biochem Cell Biol (rok: 2013, tom: 45, strony: 2087-2096), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.biocel.2013.07.004 - link to the publication
  4. Specificity of cytochemical and fluorescence methods of senescence-associated β-galactosidase detection for ageing driven by replication and time.
    Authors:
    Sosińska P, Mikuła-Pietrasik J, Ryżek M, Naumowicz E, Książek K.
    Academic press:
    Biogerontology (rok: 2014, tom: 15, strony: 407-413), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s10522-014-9505-4 - link to the publication
  5. Colorectal cancer-promoting activity of the senescent peritoneal mesothelium
    Authors:
    Mikuła-Pietrasik J, Sosińska P, Maksin K, Kucińska M, Piotrowska H, Murias M, Woźniak A, Szpurek D, Książek K.
    Academic press:
    Oncotarget (rok: 2015, tom: 6, strony: 29178-29195), Wydawca: Impact Journals
    Status:
    Published
    DOI:
    10.18632/oncotarget.4932 - link to the publication
  6. Peritoneal mesothelium promotes the progression of ovarian cancer cells in vitro and in a mice xenograft model in vivo.
    Authors:
    Mikuła-Pietrasik J, Sosińska P, Kucińska M, Murias M, Maksin K, Malińska A, Ziółkowska A, Piotrowska H, Woźniak A, Książek K.
    Academic press:
    Cancer Letters (rok: 2014, tom: 355, strony: 310-315), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.canlet.2014.09.041 - link to the publication
  1. Bad impact of good cells, or how senescence of peritoneal mesothelial cells promotes the progression of ovarian malignancy
    Authors:
    Mikuła-Pietrasik J., Sosińska P., Książek K
    Conference:
    8. International Charité-Mayo-Conference "Updates in gynecology: a global perspective" (rok: 2015, ), Wydawca: Charite
    Data:
    konferencja 15-18.04
    Status:
    Published
  2. Senescence spreading in peritoneal mesothelium and fibroblasts is related to thrombospondin-1-dependent activation of transforming growth factor-β1
    Authors:
    Mikuła-Pietrasik J., Piwocka K., Książek K
    Conference:
    48th Congress of the Polish Biochemical Society (rok: 2013, ), Wydawca: Acta Biochimica Polonica
    Data:
    konferencja 2-5 Sept
    Status:
    Published
  3. Ovarian cancer cells induce premature senescence in normal peritoneal mesothelial cells by reprogramming their secretory phenotype towards adhesion and growth-promoting capabilities
    Authors:
    Mikuła-Pietrasik J., Sosińska P., Książek K.
    Conference:
    3rd World Congress on Reproduction, Oxidative Stress and Antioxidants (rok: 2014, ), Wydawca: ISANH
    Data:
    konferencja May 22-23, 2014
    Status:
    Published
  4. Ovarian cancer cells accelerate senescence of peritoneal mesothelial cells and alter their secretory phenotype towards increased production of agents that promote their adhesion and proliferation
    Authors:
    Mikuła-Pietrasik J., Sosińska P., Książek K
    Conference:
    8. International Charité-Mayo-Conference "Updates in gynecology: a global perspective" (rok: 2015, ), Wydawca: Charite
    Data:
    konferencja 15-18.04
    Status:
    Published
  5. Bad impact of good cells, Or how senescence of peritoneal mesothelial cells promotes the progression of ovarian malignancy
    Authors:
    Mikuła-Pietrasik J., Książek K
    Conference:
    7th International Conference of Contemporary Oncology: "Personalized cancer medicine and big data analysis" (rok: 2015, ), Wydawca: Współczesna Onkologia
    Data:
    konferencja 25-27.03
    Status:
    Published
  6. Bad impact of good cells, or how senescent peritoneal mesothelium promotes the progression of ovarian cancer
    Authors:
    Książek K.
    Conference:
    Bio2014 Congress (rok: 2014, ), Wydawca: Polskie Tiwarzystwo Biochemiczne
    Data:
    konferencja 8-12 Sept. 2014
    Status:
    Published
  7. Senescent human peritoneal mesothelial cells promote the intraperitoneal development of ovarian cancer metastasis
    Authors:
    Sosińska P., Mikuła-Pietrasik J., Kucińska M., Piotrowska H., Murias M., Książek K
    Conference:
    3rd World Congress on Reproduction, Oxidative Stress and Antioxidants (rok: 2014, ), Wydawca: ISANH
    Data:
    konferencja May 22-23, 2014
    Status:
    Published

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