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Analysis of a mechanism, mediators and sequence of events in the context of an assessment of stimulatory effect of senescence of human peritoneal mesothelium on the development of the intraperitoneal cancer metastases

2011/03/B/NZ3/01214

Keywords

Descriptors

  • NZ3_4: Starzenie
  • NZ3_1: Biologia komórki
  • NZ3_14: Inne zagadnienia pokrewne

Panel

NZ3 – Cellular and developmental biology: cell biology, developmental biology, ageing biology, neurobiology

Host institution

Uniwersytet Medyczny im. Karola Marcinkowskiego w Poznaniu, Wydział Lekarski II

Voivodeship: wielkopolskie

Other projects carried out by the institution »

Principal investigator (from the host institution)

dr hab. Krzysztof Stefan Książek

Number of co-investigators in the project: 7

Call

OPUS 2 – announced on 2011-09-15

Amount awarded
857 520 PLN
Project start date
2012-08-30
Project end date
2015-08-29
Project duration
36 months (the same as in the proposal)
Project status
Project settled

Equipment purchased [PL]

  1. komora z laminarnym przepływem powietrza. Cost: 40 000 PLN
  2. mikroskop świetlny.
  3. stacja wymiany klatek. Cost: 50 000 PLN

Information in the final report

Publication in academic press/journals (6)

  1. Starzenie się komórek mezotelialnych

    Authors:
    Mikuła-Pietrasik J, Ksiazek K.
    Academic press:
    Postępy Biochemii (year: 2014, volume: 60, pages: 187-193), Publisher: Polskie Towarzystwo Biochemiczne
    Status:
    Published

  2. Specificity of cytochemical and fluorescence methods of senescence-associated β-galactosidase detection for ageing driven by replication and time.

    Authors:
    Sosińska P, Mikuła-Pietrasik J, Ryżek M, Naumowicz E, Książek K.
    Academic press:
    Biogerontology (year: 2014, volume: 15, pages: 407-413), Publisher: Springer
    Status:
    Published
    DOI:
    10.1007/s10522-014-9505-4 – link to the publication

  3. Colorectal cancer-promoting activity of the senescent peritoneal mesothelium

    Authors:
    Mikuła-Pietrasik J, Sosińska P, Maksin K, Kucińska M, Piotrowska H, Murias M, Woźniak A, Szpurek D, Książek K.
    Academic press:
    Oncotarget (year: 2015, volume: 6, pages: 29178-29195), Publisher: Impact Journals
    Status:
    Published
    DOI:
    10.18632/oncotarget.4932 – link to the publication

  4. Peritoneal mesothelium promotes the progression of ovarian cancer cells in vitro and in a mice xenograft model in vivo.

    Authors:
    Mikuła-Pietrasik J, Sosińska P, Kucińska M, Murias M, Maksin K, Malińska A, Ziółkowska A, Piotrowska H, Woźniak A, Książek K.
    Academic press:
    Cancer Letters (year: 2014, volume: 355, pages: 310-315), Publisher: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.canlet.2014.09.041 – link to the publication

  5. Bystander senescence in human peritoneal mesothelium and fibroblasts is related to thrombospondin-1-dependent activation of transforming growth factor-β1

    Authors:
    Mikuła-Pietrasik J, Sosińska P, Janus J, Rubiś B, Brewińska-Olchowik M, Piwocka K, Książek K.
    Academic press:
    Int J Biochem Cell Biol (year: 2013, volume: 45, pages: 2087-2096), Publisher: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.biocel.2013.07.004 – link to the publication

  6. Senescent peritoneal mesothelium induces a pro-angiogenic phenotype in ovarian cancer cells in vitro and in a mouse xenograft model in vivo

    Authors:
    Mikuła-Pietrasik J, Sosińska P, Naumowicz E, Maksin K, Piotrowska H, Woźniak A, Szpurek D, Książek K.
    Status:
    Accepted for publication

Articles in post-conference publications (7)

  1. Senescence spreading in peritoneal mesothelium and fibroblasts is related to thrombospondin-1-dependent activation of transforming growth factor-β1

    Authors:
    Mikuła-Pietrasik J., Piwocka K., Książek K
    Conference:
    48th Congress of the Polish Biochemical Society (year: 2013, pages: 69-69), Publisher: Acta Biochimica Polonica
    Date:
    conference 2-5 Sept
    Status:
    Published

  2. Ovarian cancer cells induce premature senescence in normal peritoneal mesothelial cells by reprogramming their secretory phenotype towards adhesion and growth-promoting capabilities

    Authors:
    Mikuła-Pietrasik J., Sosińska P., Książek K.
    Conference:
    3rd World Congress on Reproduction, Oxidative Stress and Antioxidants (year: 2014, pages: 58), Publisher: ISANH
    Date:
    conference May 22-23, 2014
    Status:
    Published

  3. Bad impact of good cells, or how senescent peritoneal mesothelium promotes the progression of ovarian cancer

    Authors:
    Książek K.
    Conference:
    Bio2014 Congress (year: 2014, pages: 173), Publisher: Polskie Tiwarzystwo Biochemiczne
    Date:
    conference 8-12 Sept. 2014
    Status:
    Published

  4. Senescent human peritoneal mesothelial cells promote the intraperitoneal development of ovarian cancer metastasis

    Authors:
    Sosińska P., Mikuła-Pietrasik J., Kucińska M., Piotrowska H., Murias M., Książek K
    Conference:
    3rd World Congress on Reproduction, Oxidative Stress and Antioxidants (year: 2014, pages: 70), Publisher: ISANH
    Date:
    conference May 22-23, 2014
    Status:
    Published

  5. Bad impact of good cells, or how senescence of peritoneal mesothelial cells promotes the progression of ovarian malignancy

    Authors:
    Mikuła-Pietrasik J., Sosińska P., Książek K
    Conference:
    8. International Charité-Mayo-Conference Updates in gynecology: a global perspective (year: 2015, pages: 1), Publisher: Charite
    Date:
    conference 15-18.04
    Status:
    Published

  6. Ovarian cancer cells accelerate senescence of peritoneal mesothelial cells and alter their secretory phenotype towards increased production of agents that promote their adhesion and proliferation

    Authors:
    Mikuła-Pietrasik J., Sosińska P., Książek K
    Conference:
    8. International Charité-Mayo-Conference Updates in gynecology: a global perspective (year: 2015, pages: 2), Publisher: Charite
    Date:
    conference 15-18.04
    Status:
    Published

  7. Bad impact of good cells, Or how senescence of peritoneal mesothelial cells promotes the progression of ovarian malignancy

    Authors:
    Mikuła-Pietrasik J., Książek K
    Conference:
    7th International Conference of Contemporary Oncology: Personalized cancer medicine and big data analysis (year: 2015, pages: 39), Publisher: Współczesna Onkologia
    Date:
    conference 25-27.03
    Status:
    Published

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Graphic design and implementation: Jakub Piotrowski