Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Regulation of clathrin-dependent endocytosis by mTOR kinase in neuronal development

2011/03/B/NZ3/01970

Keywords:

mTOR endocytosis membrane receptors neuronal development synaptic plasticity

Descriptors:

  • NZ3_5: Molecular neurobiology
  • NZ3_6: Cell neurobiology

Panel:

NZ3 - Cellular and developmental biology: cell biology, developmental biology, ageing biology, neurobiology

Host institution :

Międzynarodowy Instytut Biologii Molekularnej i Komórkowej

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Jacek Jaworski 

Number of co-investigators in the project: 6

Call: OPUS 2 - announced on 2011-09-15

Amount awarded: 813 125 PLN

Project start date (Y-m-d): 2012-08-06

Project end date (Y-m-d): 2016-01-05

Project duration:: 41 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. Pojemnik Dewara do długoterminowego przechowywania materiału biologicznego w ciekłym azocie (10 000 PLN)
  2. In vivo elektroporator (50 000 PLN)

Information in the final report

  • Publication in academic press/journals (5)
  1. Beyond control of protein translation: what we have learned about the non-canonical regulation and function of mammalian target of rapamycin (mTOR)
    Authors:
    Anna R Malik, Malgorzata Urbanska, Matylda Macias, Agnieszka Skalecka, Jacek Jaworski
    Academic press:
    Biochim. Biophys. Acta- Proteins and Proteomics (rok: 2013, tom: 1834, strony: 1434-1448), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.bbapap.2012.12.010 - link to the publication
  2. Tuberous sclerosis complex neuropathology requires glutamate-cysteine ligase.
    Authors:
    Malik AR, Liszewska E, Skalecka A, Urbanska M, Iyer AM, Swiech LJ, Perycz M, Parobczak K, Pietruszka P, Zarebska MM, Macias M, Kotulska K, Borkowska J, Grajkowska W, Tyburczy ME, Jozwiak S, Kwiatkowski DJ, Aronica E, Jaworski J.
    Academic press:
    Acta Neuropathol Commun. (rok: 2015, tom: 0,158333333333333, strony: 45304), Wydawca: BioMed Central Ltd
    Status:
    Published
    DOI:
    10.1186/s40478-015-0225-z. - link to the publication
  3. Matricellular proteins of the Cyr61/CTGF/NOV (CCN) family and the nervous system.
    Authors:
    Malik AR, Liszewska E, Jaworski J.
    Academic press:
    Front Cell Neurosci. (rok: 2015, tom: 0,539583333333333, strony: 45304), Wydawca: Frontiers
    Status:
    Published
    DOI:
    10.3389/fncel.2015.00237 - link to the publication
  4. CYR61, A MATRICELLULAR PROTEIN, IS NEEDED FOR DENDRITIC ARBORIZATION OF HIPPOCAMPAL NEURONS
    Authors:
    Anna R. Malik, Malgorzata Urbanska, Agata Gozdz, Lukasz J. Swiech, Andrzej Nagalski, Malgorzata Perycz, Magdalena Blazejczyk, Jacek Jaworski
    Academic press:
    The Journal of Biological Chemistry (rok: 2013, tom: 288, strony: 8544-8559), Wydawca: American Society for Biochemistry and Molecular Biology
    Status:
    Published
    DOI:
    10.1074/jbc.M112.411629 - link to the publication
  5. mTOR kinase is needed for the development and stabilization of dendritic arbors in newly born olfactory bulb neurons
    Authors:
    Skałecka A., Liszewska E., Bilinski R., Gkogkas C., Khoutorsky A., Malik AR., Sonenberg N., Jaworski J.
    Academic press:
    Dev. Neurobiol. (rok: 2016, ), Wydawca: John Wiley & Sons, Inc
    Status:
    Published
    DOI:
    10.1002/dneu.22392 - link to the publication

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