Partial agonists of alpha-2 adrenoceptors as new perspective of the effective an

Partial agonists of alpha-2 adrenoceptors as new perspective of the effective and safe in reducting body weight and obesity

2011/03/B/NZ7/00635

Keywords

Descriptors

NZ7_14: Farmacja, farmakoterapia, farmakologia
NZ5_7: Leczenie chorób człowieka

Panel

NZ7 – Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology

Host institution

Uniwersytet Jagielloński- Collegium Medicum, Collegium Medicum; Wydział Farmaceutyczny

Voivodeship: małopolskie

Other projects carried out by the institution »

Principal investigator (from the host institution)

dr Magdalena Bogumiła Dudek

Number of co-investigators in the project: 16

Call

OPUS 2 – announced on 2011-09-15

Amount awarded: 916 900 PLN
Project start date: 2012-08-22
Project end date: 2016-08-21
Project duration: 48 months (the same as in the proposal)
Project status: Project settled

Equipment purchased [PL]

System do telemetrycznego pomiaru ciśnienia, EKG, temperatury i aktywności. Cost: 250 000 PLN
Waga.
Zamrażarka skrzyniowa.
Zestaw komputerowy do obsługi systemu do telemetrycznego pomiaru ciśnienia, EKG, temperatury i aktywności.

Information in the final report

Publication in academic press/journals (5)

α-Adrenoceptor antagonistic and hypotensive properties of novel arylpiperazine derivatives of pyrrolidin-2-one

Authors:
Paula Zaręba; Magdalena Dudek; Klaudia Lustyk; Agata Siwek; Gabriela Starowicz; Marek Bednarski; Leszek Nowiński; Katarzyna Raźny; Jacek Sapa; Barbara Malawska; Katarzyna Kulig

Academic press:
Bioorganic & Medicinal Chemistry (year: 2015, volume: 23, pages: 2104-2111), Publisher: Elservier

Status:
Published

DOI:
10.1016/j.bmc.2015.03.009 – link to the publication
Antiarrhythmic and α-adrenoceptors antagonistic properties of novel arylpiperazine derivatives of pyrrolidin-2-one

Authors:
Paula Zaręba; Magdalena Dudek; Klaudia Lustyk; Agata Siwek; Gabriela Starowicz; Marek Bednarski; Leszek Nowiński; Katarzyna Raźny; Jacek Sapa; Barbara Malawska; Katarzyna Kulig

Academic press:
Archive der Pahrmazie (year: 2015, volume: 348(12), pages: 861-867), Publisher: Willey

Status:
Published

DOI:
10.1002/ardp.201500180 – link to the publication
Comparison of the anorectic effect and safety of alpha2-adrenoceptor ligands: guanfacine and yohimbine in DIO rats

Authors:
Dudek Magdalena, Knutelska Joanna, Bednarski Marek, Nowiński Leszek, Pytka Karolina, Zygmunt Małgorzata, Mordyl Barbara, Głuch-Lutwin Monika, Kazek Grzegorz, Sapa Jacek

Academic press:
PlosOne (year: 2015, volume: 10(10), pages: e0141327), Publisher: Plos

Status:
Published

DOI:
10.1371/journal.pone.0141327 – link to the publication
Pyrrolidin-2-one derivatives may reduce body weight in rats with diet-induced obesity

Authors:
Magdalena Dudek, Joanna Knutelska, Marek Bednarski, Leszek Nowiński, Katarzyna Raźny, Małgorzata Zygmunt, Grzegorz Kazek, Barbara Mordyl, Monika Głuch-Lutwin, Paula Kowalczyk, Katarzyna Kulig, Jacek Sapa

Academic press:
European Journal of Pharmacology (year: 2016, volume: in press, pages: in press), Publisher: Elservier

Status:
Published

DOI:
10.1016/j.ejphar.2016.02.047 – link to the publication
EVALUATION OF ANTIPLATELET ACTIVITY OF NOVEL GUANIDINE DERIVATIVES IN THE ASPECTS OF THEIR ADRENERGIC RECEPTOR ACTIVITY

Authors:
Zagórska Agnieszka, Joanna Śniecikowska, Adam Bucki, Agata Siwek, Monika Kubacka, Grzegorz Kazek, Jacek Sapa, Magdalena Kotańska, Marcin Kołaczkowski

Status:
Accepted for publication

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