Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Partial agonists of alpha-2 adrenoceptors as new perspective of the effective and safe in reducting body weight and obesity

2011/03/B/NZ7/00635

Keywords:

partial agonist of alpha2-adrenoceptor obesity

Descriptors:

  • NZ7_14: Pharmacy, pharmacotherapy, pharmacology
  • NZ5_7: Human disease treatment

Panel:

NZ7 - Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology

Host institution :

Uniwersytet Jagielloński - Collegium Medicum, Collegium Medicum, Wydział Farmaceutyczny

woj. małopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Magdalena Dudek 

Number of co-investigators in the project: 16

Call: OPUS 2 - announced on 2011-09-15

Amount awarded: 916 900 PLN

Project start date (Y-m-d): 2012-08-22

Project end date (Y-m-d): 2016-08-21

Project duration:: 48 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. Waga.
  2. Zamrażarka skrzyniowa.
  3. Zestaw komputerowy do obsługi systemu do telemetrycznego pomiaru ciśnienia, EKG, temperatury i aktywności.
  4. System do telemetrycznego pomiaru ciśnienia, EKG, temperatury i aktywności (250 000 PLN)

Information in the final report

  • Publication in academic press/journals (8)
  1. Metabolic benefits of 1-(3-(4-(o-tolyl)piperazin-1-yl)propyl)pyrrolidin-2-one - a non- selective α-adrenoceptor antagonist
    Authors:
    Kotańska Magdalena, Kulig Katarzyna, Marcinkowska Monika, Bednarski Marek, Malawska Katarzyna, Zaręba Paula
    Academic press:
    Journal of Endocrinological Investigation , Wydawca: Springer
    Status:
    Submitted
    DOI:
    brak - link to the publication
  2. Synthesis and biological evaluation of N-arylpiperazine derivatives of 4,4-dimethylisoquinoline-1,3(2H,4H)-dione as potential antiplatelet agents
    Authors:
    Marcinkowska Monika, Kotańska Magdalena, Zagórska Agnieszka, Śniecikowska Joanna, Kubacka Monika, Siwek Agata, Bucki Adam, Pawłowski Maciej, Bednarski Marek, Sapa Jacek, Starek Małgorzata, Dąbrowska Monika, Kołaczkowski Marcin
    Academic press:
    Journal Of Enzyme Inhibition And Medicinal Chemistry , Wydawca: TAYLOR & FRANCIS LTD
    Status:
    Submitted
    DOI:
    brak - link to the publication
  3. Comparison of the anorectic effect and safety of alpha2-adrenoceptor ligands: guanfacine and yohimbine in DIO rats
    Authors:
    Dudek Magdalena, Knutelska Joanna, Bednarski Marek, Nowiński Leszek, Pytka Karolina, Zygmunt Małgorzata, Mordyl Barbara, Głuch-Lutwin Monika, Kazek Grzegorz, Sapa Jacek
    Academic press:
    PlosOne (rok: 2015, tom: 10(10), strony: e0141327), Wydawca: Plos
    Status:
    Published
    DOI:
    10.1371/journal.pone.0141327 - link to the publication
  4. Yohimbine improves lipid and carbohydrate profiles without a reduction in the body weight of ob/ob mice – the role of the α1-adrenoceptor and α2-adrenoceptor
    Authors:
    Dudek Magdalena, Knutelska Joanna, Zygmunt Małgorzata, Sapa Jacek
    Academic press:
    Pharmacology (rok: 2016, ), Wydawca: Karger
    Status:
    Submitted
    DOI:
    brak - link to the publication
  5. α-Adrenoceptor antagonistic and hypotensive properties of novel arylpiperazine derivatives of pyrrolidin-2-one
    Authors:
    Paula Zaręba; Magdalena Dudek; Klaudia Lustyk; Agata Siwek; Gabriela Starowicz; Marek Bednarski; Leszek Nowiński; Katarzyna Raźny; Jacek Sapa; Barbara Malawska; Katarzyna Kulig
    Academic press:
    Bioorganic & Medicinal Chemistry (rok: 2015, tom: 23, strony: 2104-2111), Wydawca: Elservier
    Status:
    Published
    DOI:
    10.1016/j.bmc.2015.03.009 - link to the publication
  6. EVALUATION OF ANTIPLATELET ACTIVITY OF NOVEL GUANIDINE DERIVATIVES IN THE ASPECTS OF THEIR ADRENERGIC RECEPTOR ACTIVITY
    Authors:
    Zagórska Agnieszka, Joanna Śniecikowska, Adam Bucki, Agata Siwek, Monika Kubacka, Grzegorz Kazek, Jacek Sapa, Magdalena Kotańska, Marcin Kołaczkowski
    Academic press:
    Acta Polonia Pharmacutica. Drug Research. , Wydawca: Polskie Towarzystwo Farmaceutyczne
    Status:
    Accepted for publication
    DOI:
    brak - link to the publication
  7. Antiarrhythmic and α-adrenoceptors antagonistic properties of novel arylpiperazine derivatives of pyrrolidin-2-one
    Authors:
    Paula Zaręba; Magdalena Dudek; Klaudia Lustyk; Agata Siwek; Gabriela Starowicz; Marek Bednarski; Leszek Nowiński; Katarzyna Raźny; Jacek Sapa; Barbara Malawska; Katarzyna Kulig
    Academic press:
    Archive der Pahrmazie (rok: 2015, tom: 348(12), strony: 861-867), Wydawca: Willey
    Status:
    Published
    DOI:
    10.1002/ardp.201500180 - link to the publication
  8. Pyrrolidin-2-one derivatives may reduce body weight in rats with diet-induced obesity
    Authors:
    Magdalena Dudek, Joanna Knutelska, Marek Bednarski, Leszek Nowiński, Katarzyna Raźny, Małgorzata Zygmunt, Grzegorz Kazek, Barbara Mordyl, Monika Głuch-Lutwin, Paula Kowalczyk, Katarzyna Kulig, Jacek Sapa
    Academic press:
    European Journal of Pharmacology (rok: 2016, tom: in press, strony: in press), Wydawca: Elservier
    Status:
    Published
    DOI:
    10.1016/j.ejphar.2016.02.047 - link to the publication

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