Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

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Synthesis, structure analysis, anticancer and antimicrobial activity of new derivatives of salinomycin

2011/03/D/ST5/05884

Keywords:

Antibiotics Synthesis Anticancer activity Antibacterial activity Structure Structure activity relationship SAR Spectroscopic studies,

Descriptors:

  • ST5_16:

Panel:

ST5 - Materials: materials synthesis, structure-properties relations, advanced and functional materials with designed properties, (macro)molecular architecture, material engineering

Host institution :

Uniwersytet im. Adama Mickiewicza, Wydział Chemii

woj. wielkopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr hab. Adam Huczyński 

Number of co-investigators in the project: 5

Call: SONATA 2 - announced on 2011-09-15

Amount awarded: 365 000 PLN

Project start date (Y-m-d): 2012-08-29

Project end date (Y-m-d): 2015-08-28

Project duration:: 36 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. Wyparka obrotowa z membranową pompą próżniową (21 000 PLN)
  2. notebook Dell (6 000 PLN)

Information in the final report

  • Publication in academic press/journals (7)
  1. Antiproliferative activity of salinomycin and its derivatives
    Authors:
    Adam Huczyński Jan Janczak, Michał Antoszczak, Joanna Wietrzyk, Ewa Maj, Bogumil Brzezinski
    Academic press:
    Bioorganic & Medicinal Chemistry Letters (rok: 2012, tom: 22, strony: 7146–7150), Wydawca: Elsevier B.V
    Status:
    Published
    DOI:
    10.1016/j.bmcl.2012.09.068 - link to the publication
  2. Tertiary amides of Salinomycin: A new group of antibacterial agents against Bacillus anthracis and methicillin-resistant Staphylococcus epidermidis
    Authors:
    Joanna Stefańska, Michał Antoszczak, Karolina Stępień, Michał Bartoszcze, Tomasz Mirski, Adam Huczyński
    Academic press:
    Bioorganic & Medicinal Chemistry Letters, (rok: 2015, tom: 25 (10), strony: 2082-2088), Wydawca: Elsevier B.V
    Status:
    Published
    DOI:
    10.1016/j.bmcl.2015.03.085 - link to the publication
  3. Anticancer Activity of Polyether Ionophore - Salinomycin
    Authors:
    Michał Antoszczak and Adam Huczyński
    Academic press:
    Anti-Cancer Agents in Medicinal Chemistry (Formerly: Current Medicinal Chemistry - Anti-Cancer Agents) (rok: 2015, tom: 15, strony: 575-591), Wydawca: Betham Science
    Status:
    Accepted for publication
    DOI:
    10.2174/1871520615666150101130209 - link to the publication
  4. Polyether ionophores - promising bioactive molecules for cancer therapy
    Authors:
    Adam Huczyński
    Academic press:
    Bioorganic & Medicinal Chemistry Letters (rok: 2012, tom: 23, strony: 7002-7010), Wydawca: Elsevier B.V
    Status:
    Published
    DOI:
    10.1016/j.bmcl.2012.09.046 - link to the publication
  5. Synthesis, antiproliferative and antibacterial activity of new amides of salinomycin
    Authors:
    Adam Huczynski, Michał Antoszczak, Ewa Maj, Joanna Wietrzyk, Joanna Stefańska, Jan Janczak, Bogumil Brzezinski,
    Academic press:
    Bioorganic & Medicinal Chemistry Letters (rok: 2014, tom: 24 (7), strony: 1724-1729), Wydawca: Elsevier B.V
    Status:
    Published
    DOI:
    10.1016/j.bmcl.2014.02.042 - link to the publication
  6. Synthesis, cytotoxicity and antibacterial activity of new esters of polyether antibiotic - salinomycin
    Authors:
    Adam Huczynski, Michał Antoszczak, Katarzyna Popiel, Joanna Stefańska, Ewa Maj, Joanna Wietrzyk, Jan Janczak, Bogumil Brzezinski,
    Academic press:
    European Journal of Medicinal Chemistry (rok: 2014, tom: 76, strony: 435-444), Wydawca: Elsevier B.V
    Status:
    Published
    DOI:
    10.1016/j.ejmech.2014.02.031 - link to the publication
  7. Synthesis, Anticancer and Antibacterial Activity of Salinomycin N-Benzyl Amides
    Authors:
    Michał Antoszczak, Ewa Maj, Agnieszka Napiórkowska, Joanna Stefańska, Ewa Augustynowicz-Kopeć, Joanna Wietrzyk, Jan Janczak, Bogumil Brzezinski, Adam Huczyński
    Academic press:
    Molecules (rok: 2014, tom: 2014, strony: 19435-19459), Wydawca: 19(12)
    Status:
    Published
    DOI:
    10.3390/molecules191219435 - link to the publication

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