Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

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New synthetic resveratrol derivatives with potential anti-ageing and anti-cancer properties

2011/03/N/NZ7/06277

Keywords:

cancer invasiveness cellular senescence mesothelial cells peritoneal cavity resveratrol stilbenes

Descriptors:

  • NZ7_14: Pharmacy, pharmacotherapy, pharmacology
  • NZ5_7: Human disease treatment
  • NZ3_4: Ageing

Panel:

NZ7 - Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology

Host institution :

Uniwersytet Medyczny im. Karola Marcinkowskiego w Poznaniu, Wydział Lekarski II

woj. wielkopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Justyna Mikuła-Pietrasik 

Number of co-investigators in the project: 2

Call: PRELUDIUM 2 - announced on 2011-09-15

Amount awarded: 214 500 PLN

Project start date (Y-m-d): 2012-09-04

Project end date (Y-m-d): 2015-03-03

Project duration:: 30 months (the same as in the proposal)

Project status: Project settled

Information in the final report

  • Publication in academic press/journals (4)
  • Articles in post-conference publications (5)
  1. High potency of a novel resveratrol derivative, 3,3',4,4'-tetrahydroxy-trans-stilbene, against ovarian cancer is associated with oxidative stress-mediated imbalance between DNA damage accumulation and repair
    Authors:
    Mikuła-Pietrasik J, Sosińska P, Murias M, Wierzchowski M, Brewińska-Olchowik M, Piwocka K, Szpurek D, Książek K
    Academic press:
    Oxidative Medicine and Cellular Longevity (rok: 2015, tom: 2015, strony: 45306), Wydawca: Hindawi Publishing Corporation
    Status:
    Published
    DOI:
    10.1155/2015/135691 - link to the publication
  2. Resveratrol Analogue, 3,3',4,4',5,5'-Hexahydroxy-trans-Stilbene, Accelerates Senescence in Peritoneal Mesothelium and Promotes Senescence-Dependent Growth of Gastrointestinal Cancers
    Authors:
    Mikuła-Pietrasik J.; Sosińska P.; Wierzchowski M.; Piwocka K.; Książek K
    Academic press:
    Int. J. Mol. Sci (rok: 2013, tom: 14, strony: 22483-22498), Wydawca: MDPI - Open Access Publishing
    Status:
    Published
    DOI:
    10.3390/ijms141122483 - link to the publication
  3. Resveratrol Derivative, 3,3',4,4'-Tetrahydroxy-trans-Stilbene, Retards Senescence of Mesothelial Cells via Hormetic-Like Prooxidative Mechanism.
    Authors:
    Mikuła-Pietrasik J, Sosińska P, Murias M, Michalak M, Wierzchowski M, Piechota M, Sikora E, Książek K.
    Academic press:
    J Gerontol A Biol Sci Med Sci (rok: 2015, tom: 70, strony: 1169-1180), Wydawca: Oxford Journals
    Status:
    Published
    DOI:
    10.1093/gerona/glu172 - link to the publication
  4. Resveratrol inhibits ovarian cancer cell adhesion to peritoneal mesothelium in vitro by modulating the production of α5β1integrins and hyaluronic acid
    Authors:
    Mikuła-Pietrasik J., Sosińska P., Książek K.
    Academic press:
    Gynecol Oncol (rok: 2014, tom: 134, strony: 624-630), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.ygyno.2014.06.022 - link to the publication
  1. 3,3',4,4'-tetrahydroxy-trans-stilbene exerts stronger anti-senescence properties than its natural precursor, resveratrol
    Authors:
    2.Mikuła-Pietrasik J, Sosińska P., Murias M., Wierzchowski M., Piechota M., Sikora E., Książek K
    Conference:
    Bio2014 Congress (rok: 2014, ), Wydawca: Polskie Towarzystwo Biochemiczne
    Data:
    konferencja 8-12 Sept. 2014
    Status:
    Published
  2. Resveratrol analogue, 3,3',4,4'-tetrahydroxy-trans-stilbene, restricts ovarian cancer cell progression in the oxidative stress-dependent mechanism
    Authors:
    Mikuła-Pietrasik J, Sosińska M, Murias M, Wierzchowski M, Książek K
    Conference:
    Charite-Mayo Conference: Updates in Gynecology (rok: 2015, ), Wydawca: Charite
    Data:
    konferencja 15-19 Apr 2015
    Status:
    Published
  3. Synthetic resveratrol derivative, 3,3',4,4',5,5'-hexahydroxy-trans-stilbene, accelerates senescence of mesothelial cells and promotes senescent HPMC-dependent growth of colorectal and pancreatic cancers
    Authors:
    Mikuła-Pietrasik J., Książek K
    Conference:
    48th Congress of the Polish Biochemical Society (rok: 2013, ), Wydawca: Acta Bioch Pol
    Data:
    konferencja 2-5 Sept.
    Status:
    Published
  4. Resveratrol derivative, 3,3',4,4'-tetrahydroxy-trans-stilbene, efficiently inhibits ovarian cancer cell progression via exacerbation of cellular oxidative stress
    Authors:
    3.Sosińska P., Mikuła-Pietrasik J., Murias M., Wierzchowski M., Brewińska-Olchowik M., Piwocka K., Książek K
    Conference:
    Bio2014 Congress (rok: 2014, ), Wydawca: Polskie Towarzystwo Biochemiczne
    Data:
    konferencja 8-12 Sept. 2014
    Status:
    Published
  5. Senescence-promoting activity of synthetic resveratrol analogue 3,3',4,4',5,5'-hexahydroxy-trans-stilbene
    Authors:
    Mikuła-Pietrasik J., Książek K
    Conference:
    Conference on Visualizing of senescent cells in vitro and in vivo (rok: 2012, ), Wydawca: Instytut Biologii Doświadczalnej im. M. Nenckiego PAN
    Data:
    konferencja 15-16 Dec.
    Status:
    Published

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