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New synthetic resveratrol derivatives with potential anti-ageing and anti-cancer properties

2011/03/N/NZ7/06277

Keywords

Descriptors

  • NZ7_14: Farmacja, farmakoterapia, farmakologia
  • NZ5_7: Leczenie chorób człowieka
  • NZ3_4: Starzenie

Panel

NZ7 – Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology

Host institution

Uniwersytet Medyczny im. Karola Marcinkowskiego w Poznaniu, Wydział Lekarski II

Voivodeship: wielkopolskie

Other projects carried out by the institution »

Principal investigator (from the host institution)

dr Justyna Mikuła-Pietrasik

Number of co-investigators in the project: 2

Call

PRELUDIUM 2 – announced on 2011-09-15

Amount awarded
214 500 PLN
Project start date
2012-09-04
Project end date
2015-03-03
Project duration
30 months (the same as in the proposal)
Project status
Project settled

Information in the final report

Publication in academic press/journals (4)

  1. Resveratrol Analogue, 3,3',4,4',5,5'-Hexahydroxy-trans-Stilbene, Accelerates Senescence in Peritoneal Mesothelium and Promotes Senescence-Dependent Growth of Gastrointestinal Cancers

    Authors:
    Mikuła-Pietrasik J.; Sosińska P.; Wierzchowski M.; Piwocka K.; Książek K
    Academic press:
    Int. J. Mol. Sci (year: 2013, volume: 14, pages: 22483-22498), Publisher: MDPI - Open Access Publishing
    Status:
    Published
    DOI:
    10.3390/ijms141122483 – link to the publication

  2. Resveratrol inhibits ovarian cancer cell adhesion to peritoneal mesothelium in vitro by modulating the production of α5β1integrins and hyaluronic acid

    Authors:
    Mikuła-Pietrasik J., Sosińska P., Książek K.
    Academic press:
    Gynecol Oncol (year: 2014, volume: 134, pages: 624-630), Publisher: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.ygyno.2014.06.022 – link to the publication

  3. Resveratrol Derivative, 3,3',4,4'-Tetrahydroxy-trans-Stilbene, Retards Senescence of Mesothelial Cells via Hormetic-Like Prooxidative Mechanism.

    Authors:
    Mikuła-Pietrasik J, Sosińska P, Murias M, Michalak M, Wierzchowski M, Piechota M, Sikora E, Książek K.
    Academic press:
    J Gerontol A Biol Sci Med Sci (year: 2015, volume: 70, pages: 1169-1180), Publisher: Oxford Journals
    Status:
    Published
    DOI:
    10.1093/gerona/glu172 – link to the publication

  4. High potency of a novel resveratrol derivative, 3,3',4,4'-tetrahydroxy-trans-stilbene, against ovarian cancer is associated with oxidative stress-mediated imbalance between DNA damage accumulation and repair

    Authors:
    Mikuła-Pietrasik J, Sosińska P, Murias M, Wierzchowski M, Brewińska-Olchowik M, Piwocka K, Szpurek D, Książek K
    Academic press:
    Oxidative Medicine and Cellular Longevity (year: 2015, volume: 2015, pages: 46037), Publisher: Hindawi Publishing Corporation
    Status:
    Published
    DOI:
    10.1155/2015/135691 – link to the publication

Articles in post-conference publications (5)

  1. Resveratrol analogue, 3,3',4,4'-tetrahydroxy-trans-stilbene, restricts ovarian cancer cell progression in the oxidative stress-dependent mechanism

    Authors:
    Mikuła-Pietrasik J, Sosińska M, Murias M, Wierzchowski M, Książek K
    Conference:
    Charite-Mayo Conference: Updates in Gynecology (year: 2015, pages: 3), Publisher: Charite
    Date:
    conference 15-19 Apr 2015
    Status:
    Published

  2. Senescence-promoting activity of synthetic resveratrol analogue 3,3',4,4',5,5'-hexahydroxy-trans-stilbene

    Authors:
    Mikuła-Pietrasik J., Książek K
    Conference:
    Conference on Visualizing of senescent cells in vitro and in vivo (year: 2012, pages: 60-60), Publisher: Instytut Biologii Doświadczalnej im. M. Nenckiego PAN
    Date:
    conference 15-16 Dec.
    Status:
    Published

  3. Synthetic resveratrol derivative, 3,3',4,4',5,5'-hexahydroxy-trans-stilbene, accelerates senescence of mesothelial cells and promotes senescent HPMC-dependent growth of colorectal and pancreatic cancers

    Authors:
    Mikuła-Pietrasik J., Książek K
    Conference:
    48th Congress of the Polish Biochemical Society (year: 2013, pages: 108-108), Publisher: Acta Bioch Pol
    Date:
    conference 2-5 Sept.
    Status:
    Published

  4. 3,3',4,4'-tetrahydroxy-trans-stilbene exerts stronger anti-senescence properties than its natural precursor, resveratrol

    Authors:
    2.Mikuła-Pietrasik J, Sosińska P., Murias M., Wierzchowski M., Piechota M., Sikora E., Książek K
    Conference:
    Bio2014 Congress (year: 2014, pages: 182), Publisher: Polskie Towarzystwo Biochemiczne
    Date:
    conference 8-12 Sept. 2014
    Status:
    Published

  5. Resveratrol derivative, 3,3',4,4'-tetrahydroxy-trans-stilbene, efficiently inhibits ovarian cancer cell progression via exacerbation of cellular oxidative stress

    Authors:
    3.Sosińska P., Mikuła-Pietrasik J., Murias M., Wierzchowski M., Brewińska-Olchowik M., Piwocka K., Książek K
    Conference:
    Bio2014 Congress (year: 2014, pages: 53), Publisher: Polskie Towarzystwo Biochemiczne
    Date:
    conference 8-12 Sept. 2014
    Status:
    Published

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