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Oxidation landscape of mitochondrial proteins upon ROS production and in ageing

2011/03/B/NZ2/01402

Keywords

Descriptors

  • NZ2_3: Proteomika
  • NZ3_4: Starzenie
  • NZ1_2: Biochemia

Panel

NZ2 – Genetics, genomics: molecular genetics, genomics, proteomics, bioinformatics, systems biology, genetic epidemiology

Host institution

Międzynarodowy Instytut Biologii Molekularnej i Komórkowej

Voivodeship: mazowieckie

Other projects carried out by the institution »

Principal investigator (from the host institution)

prof. Agnieszka Małgorzata Chacińska

Number of co-investigators in the project: 3

Call

OPUS 2 – announced on 2011-09-15

Amount awarded
997 500 PLN
Project start date
2012-09-12
Project end date
2016-04-11
Project duration
43 months (the same as in the proposal)
Project status
Project settled

Equipment purchased [PL]

  1. INKUBATOR Z WYTRZĄSARKĄ ECOTRON INFORS AG. Cost: 25 000 PLN
  2. Inkubator do szalkowych testów wzrostowych. Cost: 14 744 PLN
  3. System do elektroferezy, zestaw DNA pointer system model 4.1-Page. Cost: 60 000 PLN
  4. Zasilacz do aparatu do elektroforezy.

Information in the final report

Publication in academic press/journals (9)

  1. Chatty Mitochondria: Keeping Balance in Cellular Protein Homeostasis

    Authors:
    Topf, U., Wrobel, L., and Chacinska, A.
    Academic press:
    Trends in Cell Biology (year: 2016, volume: brak, pages: pii: S0962-8924(16)00040-4), Publisher: Elsevier Ltd.
    Status:
    Published
    DOI:
    10.1016/j.tcb.2016.03.002 – link to the publication

  2. Mia40 and MINOS act in parallel with Ccs1 in the biogenesis of mitochondrial Sod1

    Authors:
    Varabyova, A., Topf, U., Kwiatkowska, P., Wrobel, L., Kaus-Drobek, A., and Chacinska, A.
    Academic press:
    FEBS J (year: 2013, volume: 280, pages: 4943-4959), Publisher: WILEY-BLACKWELL
    Status:
    Published
    DOI:
    10.1111/FEBS.12409 – link to the publication

  3. The Ubiquitin-Proteasome System Regulates Mitochondrial Intermembrane Space Proteins

    Authors:
    Bragoszewski, P., Gornicka, A., Sztolsztener, M.E., and Chacinska, A.
    Academic press:
    Mol Cell Biol (year: 2013, volume: 33, pages: 2136-48), Publisher: The American Society for Cell Biology
    Status:
    Published
    DOI:
    10.1128/MCB.01579-12 – link to the publication

  4. The Oxidation Status of Mic19 Regulates MICOS Assembly

    Authors:
    Sakowska P., Jans D.C., Mohanraj K., Riedel D., Jakobs S., Chacinska A.
    Academic press:
    Molecular and Cellular Biology (year: 2015, volume: vol. 35 no. 24, pages: 4222-4237), Publisher: American Society For Microbiology
    Status:
    Published
    DOI:
    10.1128/MCB.00578-15 – link to the publication

  5. Mitochondrial protein translocases for survival and wellbeing.

    Authors:
    Sokol A.M., Sztolsztener M.E., Wasilewski M., Heinz E., Chacinska A.
    Academic press:
    FEBS Lett. (year: 2014, volume: 588(15), pages: 2484-2495), Publisher: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.febslet.2014.05.028. – link to the publication

  6. Cox17 Protein Is an Auxiliary Factor Involved in the Control of the Mitochondrial Contact Site and Cristae Organizing System

    Authors:
    Chojnacka M., Gornicka A., Oeljeklaus S., Warscheid B., Chacinska A.
    Academic press:
    Journal of Biological Chemistry (year: 2015, volume: vol. 290 no. 24, pages: 15304-15312), Publisher: American Society for Biochemistry and Molecular Biology (ASBMB)
    Status:
    Published
    DOI:
    10.1074/jbc.M115.645069 – link to the publication

  7. A discrete pathway for the transfer of intermembrane space proteins across the outer membrane of mitochondria.

    Authors:
    Gornicka A., Bragoszewski P., Chroscicki P., Wenz L.S., Schulz C., Rehling P., Chacinska A.
    Academic press:
    Mol Biol Cell (year: 2014, volume: 25, pages: 399-4009), Publisher: The American Society for Cell Biology
    Status:
    Published
    DOI:
    10.1091/mbc.E14-06-1155 – link to the publication

  8. Retro-translocation of mitochondrial intermembrane space proteins

    Authors:
    Bragoszewski P., Wasilewski M., Sakowska P., Gornicka A., Böttinger L., Qiu J., Wiedemann N., Chacinska A.
    Academic press:
    Proceedings of the National Academy of Sciences of the United States of America (year: 2015, volume: vol. 112 no. 25, pages: 7713-7718), Publisher: National Academy of Science
    Status:
    Published
    DOI:
    10.1073/pnas.1504615112 – link to the publication

  9. Mistargeted mitochondrial proteins activate a proteostatic response in the cytosol

    Authors:
    Wrobel L., Topf U., Bragoszewski P., Wiese S., Sztolsztener M.E., Oeljeklaus S., Varabyova A., Lirski M., Chroscicki P., Mroczek S., Januszewicz E., Dziembowski A., Koblowska M., Warscheid B., Chacinska A.
    Academic press:
    Nature (year: 2015, volume: vol. 524 (7566), pages: 485-488), Publisher: Macmillan Publishers Ltd.
    Status:
    Published
    DOI:
    10.1038/nature14951 – link to the publication

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