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The development of the new safe and controlled anticoagulant therapy with the use of cationically-modified polymers in the models of experimentally induced arterial and venous thrombosis.

2011/03/B/NZ7/00755

Keywords

Descriptors

  • NZ7_14: Farmacja, farmakoterapia, farmakologia

Panel

NZ7 – Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology

Host institution

Uniwersytet Medyczny w Białymstoku, Wydział Farmaceutyczny z Oddziałem Medycyny Laboratoryjnej

Voivodeship: podlaskie

Other projects carried out by the institution »

Principal investigator (from the host institution)

dr hab. Andrzej Mogielnicki

Number of co-investigators in the project: 11

Call

OPUS 2 – announced on 2011-09-15

Amount awarded
588 010 PLN
Project start date
2012-08-22
Project end date
2015-08-21
Project duration
36 months (the same as in the proposal)
Project status
Project settled

Equipment purchased [PL]

  1. Aparat do oznaczeń morfologii krwi zwierząt typu SCIL VET ABC +. Cost: 40 000 PLN
  2. Aparat do respiracji i wziewnego znieczulania izofluranem zwierząt laboratoryjnych.
  3. Przenośny aparat do pomiaru krzepliwości w kropli krwi pełnej Hemochron Model Junior Sig..
  4. System SealSafe klatek indywidualnie wentylowanych (IVC) zintegrowany z jednostką nawiewczo-wyciągową Easy Flow. Cost: 80 000 PLN

Information in the final report

Publication in academic press/journals (5)

  1. New arginine substituted derivative of poly(allylamine hydrochloride) for heparin reversal

    Authors:
    Kamil Kamiński, Bartłomiej Kałaska, Paulina Koczurkiewicz, Marta Michalik, Krzysztof Szczubiałka, Andrzej Mogielnicki, Włodzimierz Buczkob and Maria Nowakowska
    Academic press:
    MedChemComm (year: 2014, volume: 5, pages: 489-495), Publisher: Royal Society of Chemistry
    Status:
    Published
    DOI:
    10.1039/c3md00374d – link to the publication

  2. The toxicology of heparin reversal with protamine: past, present and future

    Authors:
    Sokołowska E, Kałaska B, Mikłosz J, Mogielnicki A
    Academic press:
    Expert Opinion on Drug Metabolism & Toxicology (year: 2016, volume: 12 (8), pages: 897-909), Publisher: Taylor & Francis
    Status:
    Published
    DOI:
    10.1080/17425255.2016.1194395 – link to the publication

  3. Heparin-binding copolymer reverses effects of unfractionated heparin, enoxaparin, and fondaparinux in rats and mice

    Authors:
    Kałaska B, Kamiński K, Mikłosz J, Shin-ichi Y, Sokołowska E, Błażejczyk A, Wietrzyk J, Kasacka I, Szczubiałka K, Pawlak D, Nowakowska M, Mogielnicki A
    Academic press:
    Translational Research (year: 2016, volume: 177, pages: 98-112), Publisher: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.trsl.2016.06.009 – link to the publication

  4. Nonclinical evaluation of novel cationically modified polysaccharide antidotes for unfractionated heparin

    Authors:
    Bartłomiej Kalaska, Kamil Kaminski, Emilia Sokolowska, Dominik Czaplicki, Monika Kujdowicz, Krystyna Stalinska, Joanna Bereta, Krzysztof Szczubialka, Dariusz Pawlak, Maria Nowakowska, Andrzej Mogielnicki
    Academic press:
    PLoS One (year: 2015, volume: 10(3), pages: e0119486), Publisher: PLOS
    Status:
    Published
    DOI:
    10.1371/journal.pone.0119486 – link to the publication

  5. The toxicokinetic profile of Dex40-GTMAC3 - a novel polysaccharide candidate for reversal of unfractionated heparin

    Authors:
    Sokolowska E, Kalaska B, Kaminski K, Lewandowska A, Blazejczyk A, Wietrzyk J, Kasacka I, Szczubialka K, Pawlak D, Nowakowska M, Mogielnicki A
    Academic press:
    Front Pharmacol (year: 2016, volume: 7, pages: 60), Publisher: Frontiers Media S.A.
    Status:
    Published
    DOI:
    10.3389/fphar.2016.00060 – link to the publication

Articles in post-conference publications (10)

  1. Nonclinical evaluation of heparin binding copolymer -HBC1 for restoring of blood coagulation after heparin treatment

    Authors:
    Bartłomiej Kałaska, Emilia Sokołowska, Kamil Kamiński, Joanna Mikłosz, Shin-ichi Yusa, Agnieszka Błażejczyk, Joanna Wietrzyk, Irena Kasacka, Krzysztof Szczubiałka, Dariusz Pawlak, Maria Nowakowska, Andrzej Mogielnicki
    Conference:
    TechConnect World Innovation Conference &Expo, Washington (year: 2015, pages: 3:278-280), Publisher: Taylor & Francis
    Date:
    conference 14-17.06.2015
    Status:
    Published

  2. Dex40-GTMAC3 modified dextran as a novel heparin antagonist

    Authors:
    Bartłomiej Kałaska, Kamil Kamiński, Emilia Sokołowska, Dominik Czaplicki, Monika Kujdowicz, Krystyna Stalińska, Krzysztof Szczubiałka, Joanna Bereta, Dariusz Pawlak, Maria Nowakowska, Andrzej Mogielnicki
    Conference:
    TechConnect World Innovation Conference &Expo, Washington (year: 2015, pages: 3:281-284), Publisher: Taylor & Francis
    Date:
    conference 14-17.06.2015
    Status:
    Published

  3. Dex40-GTMAC3, a new tool to reverse unfractionated heparin effects during intravascular or cardiac interventions

    Authors:
    Bartłomiej Kałaska, Kamil Kamiński, Emilia Sokołowska, Dominik Czaplicki, Krystyna Stalińska, Krzysztof Szczubiałka, Joanna Bereta, Dariusz Pawlak, Maria Nowakowska, Andrzej Mogielnicki
    Conference:
    ESC Congress London (year: 2015, pages: 36, suppl., s. 328 abstr. 1833), Publisher: European Heart Journal
    Date:
    conference 29.08-02.09.2015
    Status:
    Published

  4. Nonclinical evaluation of cationically modified polysaccharide antidotes for unfractionated heparin

    Authors:
    Bartłomiej Kałaska, Kamil Kamiński, Emilia Sokołowska, Monika Kujdowicz, Krzysztof Szczubiałka, Dariusz Pawlak, Maria Nowakowska, Andrzej Mogielnicki
    Conference:
    XXV Congress of the International Society on Thrombosis and Haemostasis (year: 2015, pages: 13, suppl. 2, s. 877), Publisher: Journal of Thrombosis and Haemostasis
    Date:
    conference 20-25.06.2015
    Status:
    Published

  5. Efficacy and safety of heparin binding copolymer - HBC1 for restoring of blood coagulation after unfractionated heparin and enoxaparin treatment

    Authors:
    Joanna Mikłosz, Bartłomiej Kałaska, Kamil Kamiński, Krzysztof Szczubiałka, Dariusz Pawlak, Maria Nowakowska, Andrzej Mogielnicki
    Conference:
    10th BIMC Bialystok International Medical Congress for Young Scienctists.Bialystok (year: 2015, pages: s. 239), Publisher: Uniwersytet Medyczny w Białymstoku - materiały zjazdowe
    Date:
    conference 14-16.05.2015
    Status:
    Published

  6. Novel synthetic copolymers able to bind unfractionated and low molecular weight heparins

    Authors:
    Bartłomiej Kałaska, Kamil Kamiński, Emilia Sokołowska, Joanna Mikłosz, Shin-ichi Yusa, Krzysztof Szczubiałka, Dariusz Pawlak, Maria Nowakowska, Andrzej Mogielnicki
    Conference:
    XXV Congress of the International Society on Thrombosis and Haemostasis (year: 2015, pages: 13, suppl. 2, s. 371), Publisher: Journal of Thrombosis and Haemostasis
    Date:
    conference 20-25.06.2015
    Status:
    Published

  7. The safty profile of new cationic dextran heparin antidotes.

    Authors:
    Emilia Sokołowska, Bartłomiej Kałaska, Kamil Kamiński, Alicja Lewandowska, Irena Kasacka, Krzysztof Szczubiałka, Dariusz Pawlak, Maria Nowakowska, Andrzej Mogielnicki
    Conference:
    ESC Congress London (year: 2015, pages: 36, suppl., s. 225 abstr. P1451), Publisher: European Heart Journal
    Date:
    conference 29.08-02.09.2015
    Status:
    Published

  8. The pharmacokinetics and immune response of new cationic dextran antidotes of heparin

    Authors:
    Bartłomiej Kałaska, Kamil Kamiński, Dominik Czaplicki, Agnieszka Błażejczyk, Emilia Sokołowska, Monika Kujdowicz, Krystyna Stalińska, Krzysztof Szczubiałka, Joanna Wietrzyk, Joanna Bereta, Dariusz Pawlak, Maria Nowakowska, Andrzej Mogielnicki
    Conference:
    XXV Congress of the International Society on Thrombosis and Haemostasis (year: 2015, pages: 13, suppl. 2, s. 884), Publisher: Journal of Thrombosis and Haemostasis
    Date:
    conference 20-25.06.2015
    Status:
    Published

  9. Kationowa pochodna dekstranu odwraca działanie przeciwzakrzepowe heparyny niefrakcjonowanej w zwierzęcych modelach zakrzepicy żylnej i tętniczej.

    Authors:
    Bartłomiej Kałaska, Emilia Sokołowska, Kamil Kamiński, Krzysztof Szczubiałka, Karol Kramkowski, Andrzej Mogielnicki, Maria Nowakowska, Włodzimierz Buczko
    Conference:
    XVII Sympozjum Sekcji Kardiologii Eksperymentalnej Polskiego Towarzystwa Kardiologicznego oraz Komitetu Nauk Fizjologicznych i Farmakologicznych Polskiej Akademii Nauk, Rynia k. Warszawy (year: 2012, pages: program konferencji), Publisher: PTK/PAN
    Date:
    conference 22-24.11.2012
    Status:
    Published

  10. New arginine-substituted derivatives of poly (allylamine hydrochloride) as good candidates to substitute protamine sulfate for heparin reversal

    Authors:
    Kamil Kamiński, Bartłomiej Kałaska, Krzysztof Szczubiałka, Andrzej Mogielnicki, Włodzimierz Buczko, Maria Nowakowska
    Conference:
    XVIIIth International Congress of the Polish Pharmacological Society (year: 2013, pages: 65, suppl., s. 53), Publisher: Pharmacological Reports
    Date:
    conference 23-25.05
    Status:
    Published
    DOI:
    link to the publication

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Graphic design and implementation: Jakub Piotrowski