Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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The role of free radicals and singlet oxygen in phototoxicity and photodynamic therapy (PDT) of tumors and bacterial infections under low oxygen concentration

2011/03/B/NZ1/00007

Keywords:

photodynamic therapy photosensitizers free radicals singlet oxygen hypoxia oxidative stress reactive oxygen species

Descriptors:

  • NZ1_3: Biophysics

Panel:

NZ1 - Molecular biology, structural biology, biotechnology: molecular biology, structural biology, biotechnology

Host institution :

Uniwersytet Jagielloński, Wydział Biochemii, Biofizyki i Biotechnologii

woj. małopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Tadeusz Sarna 

Number of co-investigators in the project: 5

Call: OPUS 2 - announced on 2011-09-15

Amount awarded: 744 960 PLN

Project start date (Y-m-d): 2012-08-02

Project end date (Y-m-d): 2015-10-01

Project duration:: 38 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. Inkubator do hodowli komórek z regulowaną zawartością tlenu (56 500 PLN)
  2. Pojemnik do przechowywania komórek w ciekłym azocie (17 563 PLN)
  3. Wirówka z chłodzeniem.
  4. Optyczny parametryczny oscylator (100 000 PLN)
  5. Kamera cyfrowa do mikroskopu (50 000 PLN)
  6. Komputery stacjonarne.
  7. Lodówka.
  8. Termoblok.
  9. XCVR-LASER & MISC.CONTROL UNIT (47 747 PLN)
  10. Zamrażarka.

Information in the final report

  • Publication in academic press/journals (5)
  1. Thoiocyanate potentiates antimicrobial photodynamic therapy: in situ generation of sulfur trioxide radical anion by singlet oxygen
    Authors:
    T.G. St. Denis, D. Vecchio, A. Zadlo, A. Rineh, M. Sadasivam, P. Avci, L. Huang, A. Kozinska, R. Chandran, T. Sarna , M.R. Hamblin
    Academic press:
    Free Radical Biology and Medicine (rok: 2013, tom: 65, strony: 800-810), Wydawca: ELSEVIER
    Status:
    Published
    DOI:
    10.1016/j.freeradbiomed.2013.08.162 - link to the publication
  2. Paradoxical potentiation of methylene blue-mediated antimicrobial photodynamic inactivation by sodium azide: Role of ambient oxygen and azide radicals
    Authors:
    L. Huang, T.G. St. Denis, Y. Xuan, Y.-Y. Huang, M. Tanaka, A. Zadlo, T. Sarna and M.R. Hamblin
    Academic press:
    Free Radical Biology and Medicine (rok: 2012, tom: 53, strony: 2062-2072), Wydawca: ELSEVIER
    Status:
    Published
    DOI:
    10.1016/j.freeradbiomed.2012.09.006 - link to the publication
  3. Photoactivation of lysosomally sequestered sunitinib after angiostatic treatment causes vascular occlusion and enhances tumor growth inhibition
    Authors:
    P Nowak-Sliwinska, A Weiss, JR van Beijnum, TJ Wong, WW Kilarski, G Szewczyk, HMW Verheul, T Sarna, H van den Bergh and AW Griffioen
    Academic press:
    Cell Death and Disease (rok: 2015, tom: 6, strony: 45300), Wydawca: Macmillan Publishers Limited
    Status:
    Published
    DOI:
    10.1038/cddis.2015.4 - link to the publication
  4. Antimicrobial photodynamic therapy with fulleropyrrolidine: photoinactivation mechanism of Staphylococcus aureus, in vitro and in vivo studies
    Authors:
    M. Grinholc, J. Nakonieczna, G. Fila, A. Taraszkiewicz, A. Kawiak, G. Szewczyk, T. Sarna, L. Lilge, K. Bielawski
    Academic press:
    Applied Microbiology and Biotechnology (rok: 2015, tom: 99, strony: 4031-4043), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s00253-015-6539-8 - link to the publication
  5. Photodynamic inactivation of Candida albicans with Imidazoacridinones: iluence of irradiance, photosensitizer uptake and reactive oxygen species generation
    Authors:
    A. Tarszkiewicz, G. szewczyk, T. Sarna, K.P. Bielawski, J. Nakonieczna
    Academic press:
    PLOS ONE (rok: 2015, tom: 10, strony: 45310), Wydawca: PLOS
    Status:
    Published
    DOI:
    10.1371/journal.pone.0129301 - link to the publication

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