The role of free radicals and singlet oxygen in phototoxicity and photodynamic therapy (PDT) of tumors and bacterial infections under low oxygen concentration
2011/03/B/NZ1/00007
Keywords
Descriptors
- NZ1_3: Biofizyka
Panel
NZ1 – Molecular biology, structural biology, biotechnology: molecular biology, structural biology, biotechnology
Host institution
Uniwersytet Jagielloński, Wydział Biochemii, Biofizyki i Biotechnologii
Voivodeship: małopolskie
Principal investigator (from the host institution)
Number of co-investigators in the project: 5
Call
OPUS 2 – announced on 2011-09-15
- Amount awarded
- 744 960 PLN
- Project start date
- 2012-08-02
- Project end date
- 2015-10-01
- Project duration
- 38 months (the same as in the proposal)
- Project status
- Project settled
Equipment purchased [PL]
- Inkubator do hodowli komórek z regulowaną zawartością tlenu. Cost: 56 500 PLN
- Kamera cyfrowa do mikroskopu. Cost: 50 000 PLN
- Komputery stacjonarne.
- Lodówka.
- Optyczny parametryczny oscylator. Cost: 100 000 PLN
- Pojemnik do przechowywania komórek w ciekłym azocie. Cost: 17 563 PLN
- Termoblok.
- Wirówka z chłodzeniem.
- XCVR-LASER & MISC.CONTROL UNIT. Cost: 47 747 PLN
- Zamrażarka.
Information in the final report
Publication in academic press/journals (5)
-
Photodynamic inactivation of Candida albicans with Imidazoacridinones: iluence of irradiance, photosensitizer uptake and reactive oxygen species generation
- Authors:
- A. Tarszkiewicz, G. szewczyk, T. Sarna, K.P. Bielawski, J. Nakonieczna
- Academic press:
- PLOS ONE (year: 2015, volume: 10, pages: 46041), Publisher: PLOS
- Status:
- Published
- DOI:
- 10.1371/journal.pone.0129301 – link to the publication
-
Paradoxical potentiation of methylene blue-mediated antimicrobial photodynamic inactivation by sodium azide: Role of ambient oxygen and azide radicals
- Authors:
- L. Huang, T.G. St. Denis, Y. Xuan, Y.-Y. Huang, M. Tanaka, A. Zadlo, T. Sarna and M.R. Hamblin
- Academic press:
- Free Radical Biology and Medicine (year: 2012, volume: 53, pages: 2062-2072), Publisher: ELSEVIER
- Status:
- Published
- DOI:
- 10.1016/j.freeradbiomed.2012.09.006 – link to the publication
-
Thoiocyanate potentiates antimicrobial photodynamic therapy: in situ generation of sulfur trioxide radical anion by singlet oxygen
- Authors:
- T.G. St. Denis, D. Vecchio, A. Zadlo, A. Rineh, M. Sadasivam, P. Avci, L. Huang, A. Kozinska, R. Chandran, T. Sarna , M.R. Hamblin
- Academic press:
- Free Radical Biology and Medicine (year: 2013, volume: 65, pages: 800-810), Publisher: ELSEVIER
- Status:
- Published
- DOI:
- 10.1016/j.freeradbiomed.2013.08.162 – link to the publication
-
Photoactivation of lysosomally sequestered sunitinib after angiostatic treatment causes vascular occlusion and enhances tumor growth inhibition
- Authors:
- P Nowak-Sliwinska, A Weiss, JR van Beijnum, TJ Wong, WW Kilarski, G Szewczyk, HMW Verheul, T Sarna, H van den Bergh and AW Griffioen
- Academic press:
- Cell Death and Disease (year: 2015, volume: 6, pages: 46031), Publisher: Macmillan Publishers Limited
- Status:
- Published
- DOI:
- 10.1038/cddis.2015.4 – link to the publication
-
Antimicrobial photodynamic therapy with fulleropyrrolidine: photoinactivation mechanism of Staphylococcus aureus, in vitro and in vivo studies
- Authors:
- M. Grinholc, J. Nakonieczna, G. Fila, A. Taraszkiewicz, A. Kawiak, G. Szewczyk, T. Sarna, L. Lilge, K. Bielawski
- Academic press:
- Applied Microbiology and Biotechnology (year: 2015, volume: 99, pages: 4031-4043), Publisher: Springer
- Status:
- Published
- DOI:
- 10.1007/s00253-015-6539-8 – link to the publication