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Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Pharmacological evaluation of possible neuroprotective strategies in novel genetic mouse models of progressive neurodegeneration, based on tissue specific inducible Cre/loxP system

2011/03/B/NZ7/05949

Keywords:

neurodegeneration neuroprotection noradrenergic system TIF-IA Parkinson's disease

Descriptors:

  • NZ7_14: Pharmacy, pharmacotherapy, pharmacology
  • NZ3_5: Molecular neurobiology
  • NZ4_7: Neurophysiology

Panel:

NZ7 - Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology

Host institution :

Instytut Farmakologii PAN

woj. małopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Grzegorz Kreiner 

Number of co-investigators in the project: 5

Call: OPUS 2 - announced on 2011-09-15

Amount awarded: 471 000 PLN

Project start date (Y-m-d): 2012-08-22

Project end date (Y-m-d): 2016-04-21

Project duration:: 44 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. GelX - Zautomatyzowany system dokumentacji żeli agarozowych (27 100 PLN)
  2. Wytrząsarka laboratoryjna (3 775 PLN)
  3. Aparat do analizy koordynacji ruchowej myszy (ROTAROD) (25 300 PLN)
  4. Komplet filtrów wzbudzania i pochłaniania do analizatora chemiluminescencji/fluorescencji (doposażenie istniejącej aparatury) (21 999 PLN)

Information in the final report

  • Publication in academic press/journals (3)
  • Articles in post-conference publications (9)
  1. Compensatory mechanisms in genetic models of neurodegeneration: are the mice better than humans?
    Authors:
    Kreiner G
    Academic press:
    Frontiers in Cellular Neuroscience - Front Cell Neurosci (rok: 2015, tom: Vol 9, 56, strony: 45297), Wydawca: Frontiers Research Foundation
    Status:
    Published
    DOI:
    10.3389/fncel.2015.00056 - link to the publication
  2. A neuroprotective phase precedes striatal degeneration upon nucleolar stress
    Authors:
    Kreiner G, Bierhoff H, Armentano M, Rodriguez-Parkitna J, Sowodniok K, Naranjo JR, Bonfanti L, Liss B, Schütz G, Grummt I, Parlato R
    Academic press:
    Cell Death & Differentiation - Cell Death Differ (rok: 2013, tom: 20, strony: 1455-1464), Wydawca: NPG - Nature Publishig Group
    Status:
    Published
    DOI:
    10.1038/cdd.2013.66 - link to the publication
  3. Nucleolar activity in neurodegenerative diseases: a missing piece of the puzzle ?
    Authors:
    Parlato R, Kreiner G
    Academic press:
    Journal of Molecular Medicine - J Mol Med (rok: 2013, tom: 91, strony: 541-547), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s00109-012-0981-1 - link to the publication
  1. Involvement of noradrenergic system in Parkinson's disease - study on novel transgenic mouse models
    Authors:
    Rafa-Zabłocka K, Jurga A, Baginska M, Parlato R, Schuetz G, Nalepa I, Kreiner G
    Conference:
    27th ECNP Congress, Berlin, Niemcy (rok: 2014, ), Wydawca: Eur Neuropsychopharmacol
    Data:
    konferencja 18-21.10
    Status:
    Published
    DOI:
    link to the publication
  2. Targeting nucleolus - a new approach in generating transgenic mouse models of neurodegenerative diseases and their exploitation to study possible neuroprotective therapies
    Authors:
    Kreiner G
    Conference:
    13-th Transgenic Technology Meeting, Praga (Czechy) (rok: 2016, ), Wydawca: Transgenic Research / Springer
    Data:
    konferencja 20-23.03
    Status:
    Published
    DOI:
    link to the publication
  3. Mice with genetically evoked selective loss of noradrenergic system as a possible tool to study presmptomatic phase of Parkinson's Disease
    Authors:
    Kreiner G, Jurga A, Kot M, Rafa-Zabłocka K, Bagińska M, Parlato R, Scheutz G, Daniel WA, Nalepa I
    Conference:
    Dopamine 2013, Alghero, Włochy (rok: 2013, ), Wydawca: n/a
    Data:
    konferencja 24-28.05
    Status:
    Published
  4. Investigation of long-term effects of genetically evoked selective noradrenergic denervation on dopaminergic system functioning
    Authors:
    Jurga A, Rafa-Zabłocka K, Kot M, Daniel WA, Nalepa I, Kreiner G
    Conference:
    Neuronus 2013 IBRO&IRUN Neuroscience Forum, Kraków, Polska (rok: 2013, ), Wydawca: n/a
    Data:
    konferencja 9-11.05
    Status:
    Published
  5. Noradrenergic signaling in Parkinson's disease
    Authors:
    Kreiner G
    Conference:
    Neurochemical Conference 2015 "Neuropsychoimmunological mechanisms in the pathology of neurodegenerative diseases - from biomarkers to therapeutics", Warszawa, Polska (rok: 2015, ), Wydawca: Folia Neuropathologica
    Data:
    konferencja 22-23.10
    Status:
    Published
  6. Nucleolar activity in neurodegenrative diseases
    Authors:
    Kreiner G, Parlato R
    Conference:
    XVIII-th International Congress of the Polish Pharmacological Society, Kazimierz Dolny, Polska (rok: 2013, ), Wydawca: Pharmacological Reports / Elsevier
    Data:
    konferencja 23-25.05
    Status:
    Published
  7. The effects of trehalose administration on autophagy enhancement in mice with conditional and progressive degeneration of medial spiny neurons
    Authors:
    Kreiner G, Rafa-Zabłocka K, Bagińska M, Nalepa I
    Conference:
    12-th International Congress of Polish Neuroscience Society, Gdańsk, Polska (rok: 2015, ), Wydawca: n/a
    Data:
    konferencja 6-8.09
    Status:
    Published
  8. Characterization of mice with genetically evoked selective degeneration of noadrenergic system and its possible influence on dopaminergic system
    Authors:
    Jurga A, Kreiner G, Rafa-Zabłocka K, Bagińska M, Parlato R, Schuetz G, Nalepa I
    Conference:
    XI International Symposium, Molecular basis of pathology and therapy in neurological disorders, Warszawa, Polska (rok: 2012, ), Wydawca: n/a
    Data:
    konferencja 22-23.11
    Status:
    Published
  9. Nucleolar stress: new insights into the molecular mechanisms of Parkinson's disease
    Authors:
    Kreiner G
    Conference:
    Neurochemical Conference 2013 "Emerging topics in neurological diseases: molecular mechanisms, diagnosis and therapy", Warszawa, Polska (rok: 2013, ), Wydawca: Folia Neuropathol
    Data:
    konferencja 24-25.10
    Status:
    Published

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