The role of orexin receptor 1 and 2 (OXR1, OXR2) in the regulation of pancreatic beta and alpha cells functions

2011/03/N/NZ4/02965

Keywords

Descriptors

  • NZ4_2: Fizjologia
  • NZ4_11: Metabolizm
  • NZ4_6: Endokrynologia

Panel

NZ4 – Biology of tissues, organs and organisms: morphology and functions of animal's and human's systems, organs and organisms, experimental medicine, basics of neurology

Host institution

Uniwersytet Przyrodniczy w Poznaniu, Wydział Hodowli i Biologii Zwierząt

Voivodeship: wielkopolskie

Other projects carried out by the institution »

Principal investigator (from the host institution)

dr Marek Skrzypski

Number of co-investigators in the project: 2

Call

PRELUDIUM 2 – announced on 2011-09-15

Amount awarded
269 850 PLN
Project start date
2012-11-19
Project end date
2015-11-18
Project duration
36 months (the same as in the proposal)
Project status
Project settled

Equipment purchased [PL]

  1. Płatkarka lodu SCOTSMAN AF 80 AS. Cost: 17 000 PLN

Information in the final report

Publication in academic press/journals (3)

  1. Activation of TRPV4 channel in pancreatic INS-1E beta cells enhances glucose-stimulated insulin secretion via calcium-dependent mechanisms

    Authors:
    Skrzypski M., Kakkassery M., Mergler S., Grötzinger C., Khajavi N., Sassek M., Szczepankiewicz D., Wiedenmann B., Nowak K.W., Strowski M.
    Academic press:
    Febs Letters (year: 2013, volume: 587, pages: 3281-3287), Publisher: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.febslet.2013.08.025 – link to the publication
  2. Glucagon Regulates Orexin A Secretion in Humans and Rodents

    Authors:
    Arafat A. M, Kaczmarek P., Skrzypski M., Pruszyńska-Oszmalek E., Kołodziejski P., Adamidou A., Ruhla S., Szczepankiewicz D., Sassek M., Billert M., Wiedenmann B.,. Pfeiffer A. F.H,. Nowak K. W, Strowski M. Z.
    Academic press:
    Diabetologia (year: 2014, volume: 57, pages: 2108-2116), Publisher: Springer Science+Business Media
    Status:
    Published
    DOI:
    10.1007/s00125-014-3335-4 – link to the publication
  3. Orexin A modulates INS-1E cell proliferation and insulin secretion via extracellular signal-regulated kinase and transient receptor potential channels

    Authors:
    Skrzypski M., Khajavi N., Mergler S., Billert M., Szczepankiewicz M., Wojciechowicz M., Nowak K.W., Strowski M.Z.
    Status:
    Accepted for publication

Articles in post-conference publications (2)

  1. Orexin A stimulates INS-1E cell proliferation via ERK1/2-dependent signaling

    Authors:
    Billert M., Skrzypski M., Rogalska K., Kołodziejski P., Strowski M.Z., Nowak K.W.
    Conference:
    Bioopen I Ogólnopolska Konferencja Doktorantów Nauk o Życiu (year: 2015, pages: 182), Publisher: Uniwersytet Łódzki
    Date:
    conference 20-22 kwietnia
    Status:
    Published
    DOI:
    link to the publication
  2. Orexin A improves glycemic control and pancreatic beta cells functions in animal model of type 2 diabetes

    Authors:
    M. Skrzypski, P. Kaczmarek, E. Pruszynska-Oszmalek, M. Sassek, P. A. Kolodziejski, M. Kaczmarek, M. Billert, D. Szczepankiewicz, K. Stupiak, P. Maechler, B. Wiedenmann, K.W. Nowak, M.Z. Strowski
    Conference:
    29th Congress of the Federation of the International Danube Symposia on Diabetes mellitus 9th Congress of Central European Diabetes Association, Jurmala, Latvia (year: 2014, pages: October 2014, 5:315), Publisher: Verlag Kirchheim + Co GmbH
    Date:
    conference 26-28.07.2014
    Status:
    Published

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