Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Advanced techniques of circular dichroism as a valuable tool in structural analysis of pharmacologically important compounds.

2011/03/N/ST4/02426

Keywords:

circular dichroism (CD) absolute configuration density functional theory (DFT) thymine derivatives polymorphism adrenergic drugs

Descriptors:

  • ST4_3: Molecular architecture and structure

Panel:

ST4 - Chemistry: physical chemistry/chemical physics, theoretical chemistry, analytical chemistry, inorganic chemistry, organic chemistry, method development

Host institution :

INSTYTUT CHEMII ORGANICZNEJ PAN

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Marcin Górecki 

Number of co-investigators in the project: 3

Call: PRELUDIUM 2 - announced on 2011-09-15

Amount awarded: 216 000 PLN

Project start date (Y-m-d): 2012-08-20

Project end date (Y-m-d): 2015-10-19

Project duration:: 38 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. Eksykator szafkowy. (3 500 PLN)
  2. Kapsuła stalowa z kulkami do posiadanego młynka wibracyjnego. (1 500 PLN)
  3. Komputer przenośny. (6 000 PLN)
  4. Tabletkarka do tworzenia 13 mm tabletek. (3 000 PLN)
  5. Oprogramowanie do komputera (program Conflex, podstawowe programy do pracy naukowej)..
  6. Płuczka ultradźwiękowa z możliwością podgrzewania wody. (2 500 PLN)

Information in the final report

  • Publication in academic press/journals (6)
  • Articles in post-conference publications (7)
  1. Enantioselective Extraction System Containing Binary Chiral Selectors and Chromatographic Enantioseparation Method for Determination of the Absolute Configuration of Enantiomers of Cyclopentolate
    Authors:
    K. Szwed, M. Górecki, J. Frelek, M. Asztemborska
    Academic press:
    Chromatographia (rok: 2013, tom: 76, strony: 1603-1611), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s10337-013-2538-z - link to the publication
  2. Complementarity of electronic and vibrational circular dichroism spectroscopy in structure determination of vic-amino alcohols
    Authors:
    M. Górecki, M. Jawiczuk, J. Frelek
    Academic press:
    Journal of Bioanalysis and Biomedicine (rok: 2015, tom: 7, strony: e130), Wydawca: OMICS International
    Status:
    Published
    DOI:
    10.4172/1948-593X.1000e130 - link to the publication
  3. A Configurational and Conformational Study of (-)-Oseltamivir Using a Multi-Chiroptical Approach
    Authors:
    M. Górecki
    Academic press:
    Organic & Biomolecular Chemistry (rok: 2015, tom: 13, strony: 2999-3010), Wydawca: RSC
    Status:
    Published
    DOI:
    10.1039/C3OB42376J - link to the publication
  4. Determination of the Stereostructure of Pyrimidine Nucleoside Derivatives with a Combination of Various Chiroptical Methods
    Authors:
    M. Górecki,* A. Karczmarska-Wódzka, R. Kołodziejska, M. Dramiński, J. Frelek
    Academic press:
    European Journal of Organic Chemistry (rok: 2014, tom: 24, strony: 5204-5213), Wydawca: Wiley
    Status:
    Published
    DOI:
    10.1002/ejoc.201402190 - link to the publication
  5. Comprehensive spectroscopic characterization of finasteride polymorphic forms. Does the form X exist?
    Authors:
    J. Frelek, M. Górecki, A. Dziedzic, E. Jabłońska, B. Kamieński, R. K. Wojcieszczyk, R. Luboradzki, W. J. Szczepek
    Academic press:
    Journal of Pharmaceutical Sciences (rok: 2015, tom: 104, strony: 1650-1657), Wydawca: Wiely
    Status:
    Published
    DOI:
    10.1002/jps.24369 - link to the publication
  6. Transmission vs. Diffuse Transmission in Circular Dichroism: What to Choose for Probing Solid-State Samples?
    Authors:
    M. Górecki
    Academic press:
    Chirality (rok: 2015, tom: 27, strony: 441-448), Wydawca: Wiley
    Status:
    Published
    DOI:
    10.1002/chir.22468. - link to the publication
  1. Circular dichroic study on polymorphism phenomenon of chiral active pharmaceutical ingredients
    Authors:
    M. Górecki, W. J. Szczepek, J. Frelek
    Conference:
    The 25th International Symposium on Chirality (rok: 2013, ), Wydawca: Shanghai Institute of Organic Chemistry (SIOC), Chinese Academy of Sciences (CAS)
    Data:
    konferencja 7-10 VII
    Status:
    Published
  2. Structure determination of bioactive compounds by simultaneous application of multiple chiroptical methods
    Authors:
    M. Górecki, J. Frelek
    Conference:
    14th International Conference on Chiroptical Spectroscopy (CD 2013) (rok: 2013, ), Wydawca: Vanderbilt University
    Data:
    konferencja 9-13 VI
    Status:
    Published
  3. Distinguishing Between Polymorphic Forms of Chiral Active Pharmaceutical Ingredients by Solid-State Circular Dichroism
    Authors:
    M. Górecki, W. J. Szczepek, J. Frelek
    Conference:
    6th International Conference on Drug Discovery and Therapy (rok: 2014, ), Wydawca: Eureka Science Ltd.
    Data:
    konferencja 10-12 II
    Status:
    Published
  4. Circular Dichroism for Probing Polymorphs of Chiral Active Pharmaceutical Ingredients (APIs)
    Authors:
    M. Górecki, W. J. Szczepek, J. Frelek
    Conference:
    15th International Conference on Chiroptical Spectroscopy (CD 2015) (rok: 2015, ), Wydawca: Hokkaido University
    Data:
    konferencja 30 VIII -3 IX 2015
    Status:
    Published
  5. Komplementarne użycie metod chiralooptycznych w analizie stereochemicznej związków aktywnych biologicznie
    Authors:
    M. Górecki, J. Frelek
    Conference:
    III konferencja pt. Związki biologicznie czynne – aktywność, struktura, synteza" (rok: 2013, ), Wydawca: Instytut Chemii, Uniwersytetu w Białymstoku
    Data:
    konferencja 4-6 X
    Status:
    Published
  6. Electronic and Vibrational Circular Dichroism as a Tool for Differentiation of Polymorphic Forms of Chiral Active Pharmaceutical Ingredients (APIs)
    Authors:
    M. Górecki, A. Szugajew, W. J. Szczepek, J. Frelek
    Conference:
    4th International Conference on Vibrational Optical Activity (VOA-4) (rok: 2014, ), Wydawca: University of Hebei (Boading)
    Data:
    konferencja 26–29 X
    Status:
    Published
  7. Solid-state chiroptical study of linezolid and finasteride
    Authors:
    M. Górecki, W. J. Szczepek, J. Frelek
    Conference:
    The 9th edition of the European Conference of Computational Chemistry (EuCo-CC) (rok: 2013, ), Wydawca: European Association for Chemical and Molecular Sciences, Division of Computational Chemistry
    Data:
    konferencja 1-5 IX
    Status:
    Published

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