The significance of bioactive lipids in regulation of stem cells mobilization and homing.

2011/02/A/NZ4/00035

Keywords

Descriptors

  • NZ3_8: Komórki macierzyste

Panel

NZ4 – Biology of tissues, organs and organisms: morphology and functions of animal's and human's systems, organs and organisms, experimental medicine, basics of neurology

Host institution

Pomorski Uniwersytet Medyczny w Szczecinie, Wydział Lekarski z Oddziałem Nauczania w Języku Angielskim

Voivodeship: zachodniopomorskie

Other projects carried out by the institution »

Principal investigator (from the host institution)

prof. Mariusz Zdzisław Ratajczak

Number of co-investigators in the project: 6

Call

MAESTRO 1 – announced on 2011-06-15

Amount awarded
2 978 900 PLN
Project start date
2012-04-30
Project end date
2017-04-30
Project duration
60 months (the same as in the proposal)
Project status
Project settled

Equipment purchased [PL]

  1. Personalny komputer. Cost: 30 000 PLN

Information in the final report

Publication in academic press/journals (34)

  1. Bioactive lipids and cationic antimicrobial peptides as new potential regulators for trafficking of bone marrow-derived stem cells in patients with acute myocardial infarction

    Authors:
    Karapetyan AV, Klyachkin YM, Selim S, Sunkara M, Ziada KM, Cohen DA, Zuba-Surma EK, Ratajczak J, Smyth SS, Ratajczak MZ, Morris AJ, Abdel-Latif A.
    Academic press:
    Stem Cells And Development (year: 2013, volume: 22 (11), pages: 1645-1656), Publisher: Mary Ann Liebert
    Status:
    Published
    DOI:
    10.1089/scd.2012.0488 – link to the publication
  2. Endurance Exercise Mobilizes Developmentally Early Stem Cells into Peripheral Blood and Increases Their Number in Bone Marrow: Implications for Tissue Regeneration

    Authors:
    Marycz K, Mierzejewska K, Śmieszek A, Suszynska E, Malicka I, Kucia M, Ratajczak MZ
    Academic press:
    Stem Cells International (year: 2016, volume: 5756901, pages: 46032), Publisher: Hindawi
    Status:
    Published
    DOI:
    10.1155/2016/5756901 – link to the publication
  3. Evidence of a Pivotal Role for the Distal Part of the Complement Cascade in the Diurnal Release of Hematopoietic Stem Cells Into Peripheral Blood.

    Authors:
    Borkowska S, Suszynska M, Ratajczak J, Ratajczak MZ
    Academic press:
    Cell Transplantation (year: 2016, volume: 25, pages: 275-282), Publisher: Cognizant Communication Corporation
    Status:
    Published
    DOI:
    10.3727/096368915X688489 – link to the publication
  4. Positive effects of prolonged caloric restriction on the population of very small embryonic-like stem cells - hematopoietic and ovarian implications

    Authors:
    Grymula K, Piotrowska K, Słuczanowska-Głąbowska S, Mierzejewska K, Tarnowski M, Tkacz M, Poniewierska-Baran A, Pędziwiatr D, Suszyńska E, Laszczyńska M, Ratajczak MZ
    Academic press:
    Journal of Ovarian Research (year: 2014, volume: 7, pages: 68), Publisher: BioMed Central
    Status:
    Published
    DOI:
    10.1186/1757-2215-7-68 – link to the publication
  5. Sphingosine-1-phosphate-Mediated Mobilization of Hematopoietic Stem/Progenitor Cells during Intravascular Hemolysis Requires Attenuation of SDF-1-CXCR4 Retention Signaling in Bone Marrow

    Authors:
    Mierzejewska K, Klyachkin YM, Ratajczak J, Abdel-Latif A, Kucia M, Ratajczak MZ
    Academic press:
    BioMed Research International (year: 2013, volume: 814549, pages: 46027), Publisher: Hindawi
    Status:
    Published
    DOI:
    10.1155/2013/814549 – link to the publication
  6. Human rhabdomyosarcoma cells express functional pituitary and gonadal sex hormone receptors: Therapeutic implications

    Authors:
    PONIEWIERSKA-BARAN A, SCHNEIDER G, SUN W, ABDELBASET-ISMAIL A, BARR FG, RATAJCZAK MZ
    Academic press:
    International Journal of Oncology (year: 2016, volume: 48, pages: 1815-1824), Publisher: Spandidos Publications
    Status:
    Published
    DOI:
    10.3892/ijo.2016.3439 – link to the publication
  7. Innate immunity derived factors as external modulators of the CXCL12-CXCR4 axis and their role in stem cell homing and mobilization

    Authors:
    Ratajczak MZ, Serwin K, Schneider G.
    Academic press:
    Theranostic (year: 2013, volume: 3 (1), pages: 46091), Publisher: Ivyspring International Publisher
    Status:
    Published
    DOI:
    10.7150/thno.4621 – link to the publication
  8. Histological changes of testes in growth hormone transgenic mice with high plasma level of GH and Insulin-like Growth Factor-1

    Authors:
    Piotrowska K, Słuczanowska-Głąbowska S, Kucia M, Bartke A, Laszczyńska M, Ratajczak MZ
    Academic press:
    Folia Histochemica et Cytobiologica (year: 2015, volume: 53, pages: 249-258), Publisher: Via Medica
    Status:
    Published
    DOI:
    10.5603/fhc.a2015.0024 – link to the publication
  9. Evidence that a lipolytic enzyme--hematopoietic-specific phospholipase C-β2--promotes mobilization of hematopoietic stem cells by decreasing their lipid raft-mediated bone marrow retention and increasing the promobilizing effects of granulocytes.

    Authors:
    Adamiak M, Poniewierska-Baran A, Borkowska S, Schneider G, Abdelbaset-Ismail A, Suszynska M, Abdel-Latif A, Kucia M, Ratajczak J, Ratajczak MZ
    Academic press:
    Leukemia (year: 2016, volume: 30, pages: 919-928), Publisher: Springer Nature
    Status:
    Published
    DOI:
    10.1038/leu.2015.315 – link to the publication
  10. Induction of a tumor-metastasis-receptive microenvironment as an unwanted and underestimated side effect of treatment by chemotherapy or radiotherapy

    Authors:
    Ratajczak MZ, Jadczyk T, Schneider G, Kakar SS, Kucia M
    Academic press:
    Journal of Ovarian Research (year: 2013, volume: 6, pages: 95), Publisher: BioMed Central
    Status:
    Published
    DOI:
    10.1186/1757-2215-6-95 – link to the publication
  11. The role of sphingosine-1 phosphate and ceramide-1 phosphate in trafficking of normal stem cells and malignant cells

    Authors:
    Ratajczak MZ, Suszynska M, Borkowska S, Ratajczak J, Schneider G.
    Academic press:
    Expert Opinion On Therapeutic Targets (year: 2014, volume: 18, pages: 95-107), Publisher: Informa
    Status:
    Published
    DOI:
    10.1517/14728222.2014.851671 – link to the publication
  12. Bioactive Lipids S1P and C1P Are Prometastatic Factors in Human Rhabdomyosarcoma, and Their Tissue Levels Increase in Response to Radio/Chemotherapy

    Authors:
    Schneider G, Bryndza E, Abdel-Latif A, Ratajczak J, Maj M, Tarnowski M, Klyachkin YM, Houghton P, Morris AJ, Vater A, Klussmann S, Kucia M, Ratajczak MZ
    Academic press:
    Molecular Cancer Research (year: 2013, volume: 11, pages: 793-807), Publisher: American Association for Cancer Research
    Status:
    Published
    DOI:
    10.1158/1541-7786.MCR-12-0600 – link to the publication
  13. Expression of the erythropoietin receptor by germline-derived cells - further support for a potential developmental link between the germline and hematopoiesis

    Authors:
    Suszynska M, Poniewierska-Baran A, Gunjal P, Ratajczak J, Marycz K, Kakar SS, Kucia M, Ratajczak MZ
    Academic press:
    Journal of Ovarian Research (year: 2014, volume: 7, pages: 66), Publisher: BioMed Central
    Status:
    Published
    DOI:
    10.1186/1757-2215-7-66 – link to the publication
  14. New advances in stem cell research: practical implications for regenerative medicine

    Authors:
    Ratajczak MZ, Jadczyk T, Pędziwiatr D, Wojakowski W
    Academic press:
    Polish Archives of Internal Medicine (year: 2014, volume: 124, pages: 417-426), Publisher: Medycyna Praktyczna
    Status:
    Published
    DOI:
    link to the publication
  15. The role of bioactive lipids in stem cell mobilization and homing: novel therapeutics for myocardial ischemia

    Authors:
    Klyachkin YM, Karapetyan AV, Ratajczak MZ, Abdel-Latif A
    Academic press:
    BioMed Research International (year: 2014, volume: 2014, pages: 653543), Publisher: Hindawi
    Status:
    Published
    DOI:
    10.1155/2014/653543 – link to the publication
  16. Parental imprinting regulates insulin-like growth factor signaling: a Rosetta Stone for understanding the biology of pluripotent stem cells, aging and cancerogenesis

    Authors:
    Ratajczak MZ, Shin DM, Schneider G, Ratajczak J, Kucia M
    Academic press:
    Leukemia (year: 2013, volume: 27, pages: 773-779), Publisher: Springer Nature
    Status:
    Published
    DOI:
    10.1038/leu.2012.322 – link to the publication
  17. Mobilization studies in C3-deficient mice unravel the involvement of a novel crosstalk between the coagulation and complement cascades in mobilization of hematopoietic stem/progenitor cells

    Authors:
    Borkowska S, Suszynska M, Wysoczynski M, Ratajczak MZ
    Academic press:
    Leukemia (year: 2013, volume: 27, pages: 1928-1930), Publisher: Springer Nature
    Status:
    Published
    DOI:
    10.1038/leu.2013.84 – link to the publication
  18. Downregulation of Heme Oxygenase 1 (HO-1) Activity in Hematopoietic Cells Enhances Their Engraftment After Transplantation.

    Authors:
    Adamiak M, Moore JB 4th, Zhao J, Abdelbaset-Ismail A, Grubczak K, Rzeszotek S, Wysoczynski M, Ratajczak MZ
    Academic press:
    Cell Transplantation (year: 2016, volume: 25, pages: 1265-1276), Publisher: Cognizant Communication Corporation
    Status:
    Published
    DOI:
    10.3727/096368915X688957 – link to the publication
  19. An emerging link in stem cell mobilization between activation of the complement cascade and the chemotactic gradient of sphingosine-1-phosphate

    Authors:
    Ratajczak MZ, Borkowska S, Ratajczak J.
    Academic press:
    Prostaglandins & Other Lipid Mediators (year: 2013, volume: 104, pages: 122-129), Publisher: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.prostaglandins.2012.07.003 – link to the publication
  20. Paracrine proangiopoietic effects of human umbilical cord blood-derived purified CD133+ cells--implications for stem cell therapies in regenerative medicine

    Authors:
    Ratajczak J, Kucia M, Mierzejewska K, Marlicz W, Pietrzkowski Z, Wojakowski W, Greco NJ, Tendera M, Ratajczak MZ
    Academic press:
    Stem Cells and Development (year: 2013, volume: 22, pages: 422-430), Publisher: Mary Ann Liebert
    Status:
    Published
    DOI:
    10.1089/scd.2012.0268 – link to the publication
  21. Ceramide-1-phosphate regulates migration of multipotent stromal cells and endothelial progenitor cells--implications for tissue regeneration

    Authors:
    Kim C, Schneider G, Abdel-Latif A, Mierzejewska K, Sunkara M, Borkowska S, Ratajczak J, Morris AJ, Kucia M, Ratajczak MZ
    Academic press:
    Stem Cells (year: 2013, volume: 31, pages: 500-510), Publisher: AlphaMed Press
    Status:
    Published
    DOI:
    10.1002/stem.1291 – link to the publication
  22. Horizontal transfer of RNA and proteins between cells by extracellular microvesicles: 14 years later

    Authors:
    Ratajczak MZ, Ratajczak J
    Academic press:
    Clinical and Translational Medicine (year: 2016, volume: 5, pages: 7), Publisher: SpringerOpen
    Status:
    Published
    DOI:
    10.1186/s40169-016-0087-4 – link to the publication
  23. Novel evidence that crosstalk between the complement, coagulation and fibrinolysis proteolytic cascades is involved in mobilization of hematopoietic stem/progenitor cells (HSPCs)

    Authors:
    S Borkowska, M Suszynska, K Mierzejewska, A Ismail, M Budkowska, D Salata, B Dolegowska, M Kucia, J Ratajczak, MZ Ratajczak
    Academic press:
    Leukemia (year: 2014, volume: 28, pages: 2148-2154), Publisher: Nature. Macmillan Publishers Ltd.
    Status:
    Published
    DOI:
    10.1038/leu.2014.115 – link to the publication
  24. Human rhabdomyosarcoma cells express functional erythropoietin receptor: Potential therapeutic implications

    Authors:
    Agata Poniewierska-Baran, Malwina Suszynska, Wenyue Sun, Ahmed Abdelbaset-Ismail, Gabriela Schneider, Frederic G. Barr, Mariusz Z. Ratajczak
    Academic press:
    INTERNATIONAL JOURNAL OF ONCOLOGY (year: 2015, volume: 47(5), pages: 1989-97), Publisher: International Center for Cancer Research; Ethnikon Hidryma Ereunōn (Greece), Spandidos Publications
    Status:
    Published
    DOI:
    10.3892/ijo.2015.3184 – link to the publication
  25. Hematopoietic Stem/Progenitor Cells Express Several Functional Sex Hormone Receptors—Novel Evidence for a Potential Developmental Link Between Hematopoiesis and Primordial Germ Cells

    Authors:
    Mierzejewska Katarzyna, Borkowska Sylwia, Suszynska Ewa, Suszynska Malwina, Poniewierska-Baran Agata, Maj Magda, Pedziwiatr Daniel, Adamiak Mateusz, Abdel-Latif Ahmed, Kakar Sham S., Ratajczak Janina, Kucia Magda, and Ratajczak Mariusz Z Ratajczak
    Academic press:
    Stem Cells and Development (year: 2015, volume: 24(8), pages: 927-37), Publisher: Mary Ann Liebert, Inc.
    Status:
    Published
    DOI:
    10.1089/scd.2014.0546 – link to the publication
  26. Mobilization studies in C3-deficient mice unravel the involvement of a novel crosstalk between the coagulation and complement cascades in mobilization of hematopoietic stem/progenitor cells

    Authors:
    Borkowska S, Suszynska M, Wysoczynski M, Ratajczak MZ.
    Academic press:
    Leukemia (year: 2013, volume: 27 (9), pages: 1928-30), Publisher: Macmillan Publishers Limited
    Status:
    Published
    DOI:
    10.1038/leu.2013.84 – link to the publication
  27. The effect of low and high plasma levels of insulin-like growth factor-1 (IGF-1) on the morphology of major organs: studies of Laron dwarf and bovine growth hormone transgenic (bGHTg) mice

    Authors:
    Piotrowska K, Borkowska SJ, Wiszniewska B, Laszczyńska M, Słuczanowska-Głabowska S, Havens AM, Kopchick JJ, Bartke A, Taichman RS, Kucia M, Ratajczak MZ.
    Academic press:
    Histology and Histopathology (year: 2013, volume: 28, pages: 1325-1336), Publisher: Murcia
    Status:
    Published
  28. Bioactive Lipids, LPC and LPA, Are Novel Prometastatic Factors and Their Tissue Levels Increase in Response to Radio/Chemotherapy

    Authors:
    Gabriela Schneider, Zachariah Payne Sellers, Ahmed Abdel-Latif, Andrew J. Morris, Mariusz Z. Ratajczak
    Academic press:
    Molecular Cancer Research (year: 2014, volume: 12(11), pages: 1560-73), Publisher: American Association for Cancer Research
    Status:
    Published
    DOI:
    10.1158/1541-7786.MCR-14-0188 – link to the publication
  29. Evidence that vitronectin is a potent migration-enhancing factor for cancer cells chaperoned by fibrinogen: a novel view of the metastasis of cancer cells to low-fibrinogen lymphatics and body cavities

    Authors:
    Schneider G, Bryndza E, Poniewierska-Baran A, Serwin K, Suszynska M, Sellers ZP, Merchant ML, Kaliappan A, Ratajczak J, Kucia M, Garbett NC, Ratajczak MZ
    Academic press:
    Oncotarget (year: 2016, volume: 43, pages: 69829-69843), Publisher: Impact Journals
    Status:
    Published
    DOI:
    10.18632/oncotarget.12003 – link to the publication
  30. Identification of heme oxygenase 1 (HO-1) as a novel negative regulator of mobilization of hematopoietic stem/progenitor cells.

    Authors:
    Wysoczynski M, Ratajczak J, Pedziwiatr D, Rokosh G, Bolli R, Ratajczak MZ
    Academic press:
    Stem Cell Reviews (year: 2015, volume: 11, pages: 110-118), Publisher: Springer
    Status:
    Published
    DOI:
    10.1007/s12015-014-9547-7 – link to the publication
  31. Evidence for induction of a tumor metastasisreceptive microenvironment for ovarian cancer cells in bone marrow and other organs as an unwanted and underestimated side effect of chemotherapy/radiotherapy

    Authors:
    Gunjal PM, Schneider G, Abdelbaset Ismail A, Kakar SS, Kucia M, Ratajczak MZ
    Academic press:
    Journal of Ovarian Research (year: 2015, volume: 8, pages: 20), Publisher: BioMed Central
    Status:
    Published
    DOI:
    10.1186/s13048-015-0141-7 – link to the publication
  32. Further evidence that paroxysmal nocturnal haemoglobinuria is a disorder of defective cell membrane lipid rafts

    Authors:
    Mariusz Z Ratajczak, Sylwia Borkowska, Kasia Mierzejewska, Magda Kucia, Ewa Mendek-Czajkowska, Malwina Suszynska, Vivek A Sharma, Andrzej Deptala, Wechao Song, Uwe Platzbecker, Loree Larratt, Anna Janowska-Wieczorek, Jarek Maciejewski and Janina Ratajczak
    Academic press:
    Journal of Cellular and Molecular Medicine (year: 2015, volume: 19(9), pages: 2193-201), Publisher: John Wiley & Sons Ltd
    Status:
    Published
    DOI:
    10.1111/jcmm.12605 – link to the publication
  33. 5‑Azacytidine inhibits human rhabdomyosarcoma cell growth by downregulating insulin‑like growth factor 2 expression and reactivating the H19 gene product miR‑675, which negatively affects insulin‑like growth factors and insulin signaling

    Authors:
    Maciej Tarnowski, Marta Tkacz, Michał Czerewaty, Agata Poniewierska‑Baran, Katarzyna Grymuła, Mariusz Z. Ratajczak
    Academic press:
    International Journal of Oncology (year: 2015, volume: 46(5), pages: 2241-50), Publisher: International Center for Cancer Research; Ethnikon Hidryma Ereunōn (Greece), Spandidos Publications
    Status:
    Published
    DOI:
    10.3892/ijo.2015.2906 – link to the publication
  34. Badania nad komórkami macierzystymi i ich rosnący wpływ na współczesną psychiatrię.

    Authors:
    Ratajczak MZ, Kucharska-Mazur J, Samochowiec J
    Academic press:
    Psychiatria Polska (year: 2014, volume: 48, pages: 1073-1085), Publisher: Komitet Redakcyjno-Wydawniczy Polskiego Towarzystwa Psychiatrycznego
    Status:
    Published

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Graphic design and implementation: Jakub Piotrowski