The significance of bioactive lipids in regulation of stem cells mobilization and homing.
2011/02/A/NZ4/00035
Keywords
Descriptors
- NZ3_8: Komórki macierzyste
Panel
NZ4 – Biology of tissues, organs and organisms: morphology and functions of animal's and human's systems, organs and organisms, experimental medicine, basics of neurology
Host institution
Pomorski Uniwersytet Medyczny w Szczecinie, Wydział Lekarski z Oddziałem Nauczania w Języku Angielskim
Voivodeship: zachodniopomorskie
Principal investigator (from the host institution)
prof. Mariusz Zdzisław Ratajczak
Number of co-investigators in the project: 6
Call
MAESTRO 1 – announced on 2011-06-15
- Amount awarded
- 2 978 900 PLN
- Project start date
- 2012-04-30
- Project end date
- 2017-04-30
- Project duration
- 60 months (the same as in the proposal)
- Project status
- Project settled
Equipment purchased [PL]
- Personalny komputer. Cost: 30 000 PLN
Information in the final report
Publication in academic press/journals (34)
-
Bioactive lipids and cationic antimicrobial peptides as new potential regulators for trafficking of bone marrow-derived stem cells in patients with acute myocardial infarction
- Authors:
- Karapetyan AV, Klyachkin YM, Selim S, Sunkara M, Ziada KM, Cohen DA, Zuba-Surma EK, Ratajczak J, Smyth SS, Ratajczak MZ, Morris AJ, Abdel-Latif A.
- Academic press:
- Stem Cells And Development (year: 2013, volume: 22 (11), pages: 1645-1656), Publisher: Mary Ann Liebert
- Status:
- Published
- DOI:
- 10.1089/scd.2012.0488 – link to the publication
-
Endurance Exercise Mobilizes Developmentally Early Stem Cells into Peripheral Blood and Increases Their Number in Bone Marrow: Implications for Tissue Regeneration
- Authors:
- Marycz K, Mierzejewska K, Śmieszek A, Suszynska E, Malicka I, Kucia M, Ratajczak MZ
- Academic press:
- Stem Cells International (year: 2016, volume: 5756901, pages: 46032), Publisher: Hindawi
- Status:
- Published
- DOI:
- 10.1155/2016/5756901 – link to the publication
-
Evidence of a Pivotal Role for the Distal Part of the Complement Cascade in the Diurnal Release of Hematopoietic Stem Cells Into Peripheral Blood.
- Authors:
- Borkowska S, Suszynska M, Ratajczak J, Ratajczak MZ
- Academic press:
- Cell Transplantation (year: 2016, volume: 25, pages: 275-282), Publisher: Cognizant Communication Corporation
- Status:
- Published
- DOI:
- 10.3727/096368915X688489 – link to the publication
-
Positive effects of prolonged caloric restriction on the population of very small embryonic-like stem cells - hematopoietic and ovarian implications
- Authors:
- Grymula K, Piotrowska K, Słuczanowska-Głąbowska S, Mierzejewska K, Tarnowski M, Tkacz M, Poniewierska-Baran A, Pędziwiatr D, Suszyńska E, Laszczyńska M, Ratajczak MZ
- Academic press:
- Journal of Ovarian Research (year: 2014, volume: 7, pages: 68), Publisher: BioMed Central
- Status:
- Published
- DOI:
- 10.1186/1757-2215-7-68 – link to the publication
-
Sphingosine-1-phosphate-Mediated Mobilization of Hematopoietic Stem/Progenitor Cells during Intravascular Hemolysis Requires Attenuation of SDF-1-CXCR4 Retention Signaling in Bone Marrow
- Authors:
- Mierzejewska K, Klyachkin YM, Ratajczak J, Abdel-Latif A, Kucia M, Ratajczak MZ
- Academic press:
- BioMed Research International (year: 2013, volume: 814549, pages: 46027), Publisher: Hindawi
- Status:
- Published
- DOI:
- 10.1155/2013/814549 – link to the publication
-
Human rhabdomyosarcoma cells express functional pituitary and gonadal sex hormone receptors: Therapeutic implications
- Authors:
- PONIEWIERSKA-BARAN A, SCHNEIDER G, SUN W, ABDELBASET-ISMAIL A, BARR FG, RATAJCZAK MZ
- Academic press:
- International Journal of Oncology (year: 2016, volume: 48, pages: 1815-1824), Publisher: Spandidos Publications
- Status:
- Published
- DOI:
- 10.3892/ijo.2016.3439 – link to the publication
-
Innate immunity derived factors as external modulators of the CXCL12-CXCR4 axis and their role in stem cell homing and mobilization
- Authors:
- Ratajczak MZ, Serwin K, Schneider G.
- Academic press:
- Theranostic (year: 2013, volume: 3 (1), pages: 46091), Publisher: Ivyspring International Publisher
- Status:
- Published
- DOI:
- 10.7150/thno.4621 – link to the publication
-
Histological changes of testes in growth hormone transgenic mice with high plasma level of GH and Insulin-like Growth Factor-1
- Authors:
- Piotrowska K, Słuczanowska-Głąbowska S, Kucia M, Bartke A, Laszczyńska M, Ratajczak MZ
- Academic press:
- Folia Histochemica et Cytobiologica (year: 2015, volume: 53, pages: 249-258), Publisher: Via Medica
- Status:
- Published
- DOI:
- 10.5603/fhc.a2015.0024 – link to the publication
-
Evidence that a lipolytic enzyme--hematopoietic-specific phospholipase C-β2--promotes mobilization of hematopoietic stem cells by decreasing their lipid raft-mediated bone marrow retention and increasing the promobilizing effects of granulocytes.
- Authors:
- Adamiak M, Poniewierska-Baran A, Borkowska S, Schneider G, Abdelbaset-Ismail A, Suszynska M, Abdel-Latif A, Kucia M, Ratajczak J, Ratajczak MZ
- Academic press:
- Leukemia (year: 2016, volume: 30, pages: 919-928), Publisher: Springer Nature
- Status:
- Published
- DOI:
- 10.1038/leu.2015.315 – link to the publication
-
Induction of a tumor-metastasis-receptive microenvironment as an unwanted and underestimated side effect of treatment by chemotherapy or radiotherapy
- Authors:
- Ratajczak MZ, Jadczyk T, Schneider G, Kakar SS, Kucia M
- Academic press:
- Journal of Ovarian Research (year: 2013, volume: 6, pages: 95), Publisher: BioMed Central
- Status:
- Published
- DOI:
- 10.1186/1757-2215-6-95 – link to the publication
-
The role of sphingosine-1 phosphate and ceramide-1 phosphate in trafficking of normal stem cells and malignant cells
- Authors:
- Ratajczak MZ, Suszynska M, Borkowska S, Ratajczak J, Schneider G.
- Academic press:
- Expert Opinion On Therapeutic Targets (year: 2014, volume: 18, pages: 95-107), Publisher: Informa
- Status:
- Published
- DOI:
- 10.1517/14728222.2014.851671 – link to the publication
-
Bioactive Lipids S1P and C1P Are Prometastatic Factors in Human Rhabdomyosarcoma, and Their Tissue Levels Increase in Response to Radio/Chemotherapy
- Authors:
- Schneider G, Bryndza E, Abdel-Latif A, Ratajczak J, Maj M, Tarnowski M, Klyachkin YM, Houghton P, Morris AJ, Vater A, Klussmann S, Kucia M, Ratajczak MZ
- Academic press:
- Molecular Cancer Research (year: 2013, volume: 11, pages: 793-807), Publisher: American Association for Cancer Research
- Status:
- Published
- DOI:
- 10.1158/1541-7786.MCR-12-0600 – link to the publication
-
Expression of the erythropoietin receptor by germline-derived cells - further support for a potential developmental link between the germline and hematopoiesis
- Authors:
- Suszynska M, Poniewierska-Baran A, Gunjal P, Ratajczak J, Marycz K, Kakar SS, Kucia M, Ratajczak MZ
- Academic press:
- Journal of Ovarian Research (year: 2014, volume: 7, pages: 66), Publisher: BioMed Central
- Status:
- Published
- DOI:
- 10.1186/1757-2215-7-66 – link to the publication
-
New advances in stem cell research: practical implications for regenerative medicine
- Authors:
- Ratajczak MZ, Jadczyk T, Pędziwiatr D, Wojakowski W
- Academic press:
- Polish Archives of Internal Medicine (year: 2014, volume: 124, pages: 417-426), Publisher: Medycyna Praktyczna
- Status:
- Published
- DOI:
- link to the publication
-
The role of bioactive lipids in stem cell mobilization and homing: novel therapeutics for myocardial ischemia
- Authors:
- Klyachkin YM, Karapetyan AV, Ratajczak MZ, Abdel-Latif A
- Academic press:
- BioMed Research International (year: 2014, volume: 2014, pages: 653543), Publisher: Hindawi
- Status:
- Published
- DOI:
- 10.1155/2014/653543 – link to the publication
-
Parental imprinting regulates insulin-like growth factor signaling: a Rosetta Stone for understanding the biology of pluripotent stem cells, aging and cancerogenesis
- Authors:
- Ratajczak MZ, Shin DM, Schneider G, Ratajczak J, Kucia M
- Academic press:
- Leukemia (year: 2013, volume: 27, pages: 773-779), Publisher: Springer Nature
- Status:
- Published
- DOI:
- 10.1038/leu.2012.322 – link to the publication
-
Mobilization studies in C3-deficient mice unravel the involvement of a novel crosstalk between the coagulation and complement cascades in mobilization of hematopoietic stem/progenitor cells
- Authors:
- Borkowska S, Suszynska M, Wysoczynski M, Ratajczak MZ
- Academic press:
- Leukemia (year: 2013, volume: 27, pages: 1928-1930), Publisher: Springer Nature
- Status:
- Published
- DOI:
- 10.1038/leu.2013.84 – link to the publication
-
Downregulation of Heme Oxygenase 1 (HO-1) Activity in Hematopoietic Cells Enhances Their Engraftment After Transplantation.
- Authors:
- Adamiak M, Moore JB 4th, Zhao J, Abdelbaset-Ismail A, Grubczak K, Rzeszotek S, Wysoczynski M, Ratajczak MZ
- Academic press:
- Cell Transplantation (year: 2016, volume: 25, pages: 1265-1276), Publisher: Cognizant Communication Corporation
- Status:
- Published
- DOI:
- 10.3727/096368915X688957 – link to the publication
-
An emerging link in stem cell mobilization between activation of the complement cascade and the chemotactic gradient of sphingosine-1-phosphate
- Authors:
- Ratajczak MZ, Borkowska S, Ratajczak J.
- Academic press:
- Prostaglandins & Other Lipid Mediators (year: 2013, volume: 104, pages: 122-129), Publisher: Elsevier
- Status:
- Published
- DOI:
- 10.1016/j.prostaglandins.2012.07.003 – link to the publication
-
Paracrine proangiopoietic effects of human umbilical cord blood-derived purified CD133+ cells--implications for stem cell therapies in regenerative medicine
- Authors:
- Ratajczak J, Kucia M, Mierzejewska K, Marlicz W, Pietrzkowski Z, Wojakowski W, Greco NJ, Tendera M, Ratajczak MZ
- Academic press:
- Stem Cells and Development (year: 2013, volume: 22, pages: 422-430), Publisher: Mary Ann Liebert
- Status:
- Published
- DOI:
- 10.1089/scd.2012.0268 – link to the publication
-
Ceramide-1-phosphate regulates migration of multipotent stromal cells and endothelial progenitor cells--implications for tissue regeneration
- Authors:
- Kim C, Schneider G, Abdel-Latif A, Mierzejewska K, Sunkara M, Borkowska S, Ratajczak J, Morris AJ, Kucia M, Ratajczak MZ
- Academic press:
- Stem Cells (year: 2013, volume: 31, pages: 500-510), Publisher: AlphaMed Press
- Status:
- Published
- DOI:
- 10.1002/stem.1291 – link to the publication
-
Horizontal transfer of RNA and proteins between cells by extracellular microvesicles: 14 years later
- Authors:
- Ratajczak MZ, Ratajczak J
- Academic press:
- Clinical and Translational Medicine (year: 2016, volume: 5, pages: 7), Publisher: SpringerOpen
- Status:
- Published
- DOI:
- 10.1186/s40169-016-0087-4 – link to the publication
-
Novel evidence that crosstalk between the complement, coagulation and fibrinolysis proteolytic cascades is involved in mobilization of hematopoietic stem/progenitor cells (HSPCs)
- Authors:
- S Borkowska, M Suszynska, K Mierzejewska, A Ismail, M Budkowska, D Salata, B Dolegowska, M Kucia, J Ratajczak, MZ Ratajczak
- Academic press:
- Leukemia (year: 2014, volume: 28, pages: 2148-2154), Publisher: Nature. Macmillan Publishers Ltd.
- Status:
- Published
- DOI:
- 10.1038/leu.2014.115 – link to the publication
-
Human rhabdomyosarcoma cells express functional erythropoietin receptor: Potential therapeutic implications
- Authors:
- Agata Poniewierska-Baran, Malwina Suszynska, Wenyue Sun, Ahmed Abdelbaset-Ismail, Gabriela Schneider, Frederic G. Barr, Mariusz Z. Ratajczak
- Academic press:
- INTERNATIONAL JOURNAL OF ONCOLOGY (year: 2015, volume: 47(5), pages: 1989-97), Publisher: International Center for Cancer Research; Ethnikon Hidryma Ereunōn (Greece), Spandidos Publications
- Status:
- Published
- DOI:
- 10.3892/ijo.2015.3184 – link to the publication
-
Hematopoietic Stem/Progenitor Cells Express Several Functional Sex Hormone Receptors—Novel Evidence for a Potential Developmental Link Between Hematopoiesis and Primordial Germ Cells
- Authors:
- Mierzejewska Katarzyna, Borkowska Sylwia, Suszynska Ewa, Suszynska Malwina, Poniewierska-Baran Agata, Maj Magda, Pedziwiatr Daniel, Adamiak Mateusz, Abdel-Latif Ahmed, Kakar Sham S., Ratajczak Janina, Kucia Magda, and Ratajczak Mariusz Z Ratajczak
- Academic press:
- Stem Cells and Development (year: 2015, volume: 24(8), pages: 927-37), Publisher: Mary Ann Liebert, Inc.
- Status:
- Published
- DOI:
- 10.1089/scd.2014.0546 – link to the publication
-
Mobilization studies in C3-deficient mice unravel the involvement of a novel crosstalk between the coagulation and complement cascades in mobilization of hematopoietic stem/progenitor cells
- Authors:
- Borkowska S, Suszynska M, Wysoczynski M, Ratajczak MZ.
- Academic press:
- Leukemia (year: 2013, volume: 27 (9), pages: 1928-30), Publisher: Macmillan Publishers Limited
- Status:
- Published
- DOI:
- 10.1038/leu.2013.84 – link to the publication
-
The effect of low and high plasma levels of insulin-like growth factor-1 (IGF-1) on the morphology of major organs: studies of Laron dwarf and bovine growth hormone transgenic (bGHTg) mice
- Authors:
- Piotrowska K, Borkowska SJ, Wiszniewska B, Laszczyńska M, Słuczanowska-Głabowska S, Havens AM, Kopchick JJ, Bartke A, Taichman RS, Kucia M, Ratajczak MZ.
- Academic press:
- Histology and Histopathology (year: 2013, volume: 28, pages: 1325-1336), Publisher: Murcia
- Status:
- Published
-
Bioactive Lipids, LPC and LPA, Are Novel Prometastatic Factors and Their Tissue Levels Increase in Response to Radio/Chemotherapy
- Authors:
- Gabriela Schneider, Zachariah Payne Sellers, Ahmed Abdel-Latif, Andrew J. Morris, Mariusz Z. Ratajczak
- Academic press:
- Molecular Cancer Research (year: 2014, volume: 12(11), pages: 1560-73), Publisher: American Association for Cancer Research
- Status:
- Published
- DOI:
- 10.1158/1541-7786.MCR-14-0188 – link to the publication
-
Evidence that vitronectin is a potent migration-enhancing factor for cancer cells chaperoned by fibrinogen: a novel view of the metastasis of cancer cells to low-fibrinogen lymphatics and body cavities
- Authors:
- Schneider G, Bryndza E, Poniewierska-Baran A, Serwin K, Suszynska M, Sellers ZP, Merchant ML, Kaliappan A, Ratajczak J, Kucia M, Garbett NC, Ratajczak MZ
- Academic press:
- Oncotarget (year: 2016, volume: 43, pages: 69829-69843), Publisher: Impact Journals
- Status:
- Published
- DOI:
- 10.18632/oncotarget.12003 – link to the publication
-
Identification of heme oxygenase 1 (HO-1) as a novel negative regulator of mobilization of hematopoietic stem/progenitor cells.
- Authors:
- Wysoczynski M, Ratajczak J, Pedziwiatr D, Rokosh G, Bolli R, Ratajczak MZ
- Academic press:
- Stem Cell Reviews (year: 2015, volume: 11, pages: 110-118), Publisher: Springer
- Status:
- Published
- DOI:
- 10.1007/s12015-014-9547-7 – link to the publication
-
Evidence for induction of a tumor metastasisreceptive microenvironment for ovarian cancer cells in bone marrow and other organs as an unwanted and underestimated side effect of chemotherapy/radiotherapy
- Authors:
- Gunjal PM, Schneider G, Abdelbaset Ismail A, Kakar SS, Kucia M, Ratajczak MZ
- Academic press:
- Journal of Ovarian Research (year: 2015, volume: 8, pages: 20), Publisher: BioMed Central
- Status:
- Published
- DOI:
- 10.1186/s13048-015-0141-7 – link to the publication
-
Further evidence that paroxysmal nocturnal haemoglobinuria is a disorder of defective cell membrane lipid rafts
- Authors:
- Mariusz Z Ratajczak, Sylwia Borkowska, Kasia Mierzejewska, Magda Kucia, Ewa Mendek-Czajkowska, Malwina Suszynska, Vivek A Sharma, Andrzej Deptala, Wechao Song, Uwe Platzbecker, Loree Larratt, Anna Janowska-Wieczorek, Jarek Maciejewski and Janina Ratajczak
- Academic press:
- Journal of Cellular and Molecular Medicine (year: 2015, volume: 19(9), pages: 2193-201), Publisher: John Wiley & Sons Ltd
- Status:
- Published
- DOI:
- 10.1111/jcmm.12605 – link to the publication
-
5‑Azacytidine inhibits human rhabdomyosarcoma cell growth by downregulating insulin‑like growth factor 2 expression and reactivating the H19 gene product miR‑675, which negatively affects insulin‑like growth factors and insulin signaling
- Authors:
- Maciej Tarnowski, Marta Tkacz, Michał Czerewaty, Agata Poniewierska‑Baran, Katarzyna Grymuła, Mariusz Z. Ratajczak
- Academic press:
- International Journal of Oncology (year: 2015, volume: 46(5), pages: 2241-50), Publisher: International Center for Cancer Research; Ethnikon Hidryma Ereunōn (Greece), Spandidos Publications
- Status:
- Published
- DOI:
- 10.3892/ijo.2015.2906 – link to the publication
-
Badania nad komórkami macierzystymi i ich rosnący wpływ na współczesną psychiatrię.
- Authors:
- Ratajczak MZ, Kucharska-Mazur J, Samochowiec J
- Academic press:
- Psychiatria Polska (year: 2014, volume: 48, pages: 1073-1085), Publisher: Komitet Redakcyjno-Wydawniczy Polskiego Towarzystwa Psychiatrycznego
- Status:
- Published