Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

Delete all

The significance of bioactive lipids in regulation of stem cells mobilization and homing.

2011/02/A/NZ4/00035

Keywords:

bioactive lipids stem cells mobilization homing

Descriptors:

  • NZ3_8: Stem cell biology

Panel:

NZ4 - Biology of tissues, organs and organisms: morphology and functions of animal's and human's systems, organs and organisms, experimental medicine, basics of neurology

Host institution :

Pomorski Uniwersytet Medyczny w Szczecinie, Wydział Lekarski z Oddziałem Nauczania w Języku Angielskim

woj. zachodniopomorskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Mariusz Ratajczak 

Number of co-investigators in the project: 6

Call: MAESTRO 1 - announced on 2011-06-15

Amount awarded: 2 978 900 PLN

Project start date (Y-m-d): 2012-04-30

Project end date (Y-m-d): 2017-04-30

Project duration:: 60 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. Personalny komputer (30 000 PLN)

Information in the final report

  • Publication in academic press/journals (34)
  1. Induction of a tumor-metastasis-receptive microenvironment as an unwanted and underestimated side effect of treatment by chemotherapy or radiotherapy
    Authors:
    Ratajczak MZ, Jadczyk T, Schneider G, Kakar SS, Kucia M
    Academic press:
    Journal of Ovarian Research (rok: 2013, tom: 6, strony: 95), Wydawca: BioMed Central
    Status:
    Published
    DOI:
    10.1186/1757-2215-6-95 - link to the publication
  2. Innate immunity derived factors as external modulators of the CXCL12-CXCR4 axis and their role in stem cell homing and mobilization
    Authors:
    Ratajczak MZ, Serwin K, Schneider G.
    Academic press:
    Theranostic (rok: 2013, tom: 3 (1), strony: 45361), Wydawca: Ivyspring International Publisher
    Status:
    Published
    DOI:
    10.7150/thno.4621 - link to the publication
  3. Novel evidence that crosstalk between the complement, coagulation and fibrinolysis proteolytic cascades is involved in mobilization of hematopoietic stem/progenitor cells (HSPCs)
    Authors:
    S Borkowska, M Suszynska, K Mierzejewska, A Ismail, M Budkowska, D Salata, B Dolegowska, M Kucia, J Ratajczak, MZ Ratajczak
    Academic press:
    Leukemia (rok: 2014, tom: 28, strony: 2148-2154), Wydawca: Nature. Macmillan Publishers Ltd.
    Status:
    Published
    DOI:
    10.1038/leu.2014.115 - link to the publication
  4. Ceramide-1-phosphate regulates migration of multipotent stromal cells and endothelial progenitor cells--implications for tissue regeneration
    Authors:
    Kim C, Schneider G, Abdel-Latif A, Mierzejewska K, Sunkara M, Borkowska S, Ratajczak J, Morris AJ, Kucia M, Ratajczak MZ
    Academic press:
    Stem Cells (rok: 2013, tom: 31, strony: 500-510), Wydawca: AlphaMed Press
    Status:
    Published
    DOI:
    10.1002/stem.1291 - link to the publication
  5. Evidence for induction of a tumor metastasisreceptive microenvironment for ovarian cancer cells in bone marrow and other organs as an unwanted and underestimated side effect of chemotherapy/radiotherapy
    Authors:
    Gunjal PM, Schneider G, Abdelbaset Ismail A, Kakar SS, Kucia M, Ratajczak MZ
    Academic press:
    Journal of Ovarian Research (rok: 2015, tom: 8, strony: 20), Wydawca: BioMed Central
    Status:
    Published
    DOI:
    10.1186/s13048-015-0141-7 - link to the publication
  6. Evidence that a lipolytic enzyme--hematopoietic-specific phospholipase C-β2--promotes mobilization of hematopoietic stem cells by decreasing their lipid raft-mediated bone marrow retention and increasing the promobilizing effects of granulocytes.
    Authors:
    Adamiak M, Poniewierska-Baran A, Borkowska S, Schneider G, Abdelbaset-Ismail A, Suszynska M, Abdel-Latif A, Kucia M, Ratajczak J, Ratajczak MZ
    Academic press:
    Leukemia (rok: 2016, tom: 30, strony: 919-928), Wydawca: Springer Nature
    Status:
    Published
    DOI:
    10.1038/leu.2015.315 - link to the publication
  7. Identification of heme oxygenase 1 (HO-1) as a novel negative regulator of mobilization of hematopoietic stem/progenitor cells.
    Authors:
    Wysoczynski M, Ratajczak J, Pedziwiatr D, Rokosh G, Bolli R, Ratajczak MZ
    Academic press:
    Stem Cell Reviews (rok: 2015, tom: 11, strony: 110-118), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s12015-014-9547-7 - link to the publication
  8. Sphingosine-1-phosphate-Mediated Mobilization of Hematopoietic Stem/Progenitor Cells during Intravascular Hemolysis Requires Attenuation of SDF-1-CXCR4 Retention Signaling in Bone Marrow
    Authors:
    Mierzejewska K, Klyachkin YM, Ratajczak J, Abdel-Latif A, Kucia M, Ratajczak MZ
    Academic press:
    BioMed Research International (rok: 2013, tom: 814549, strony: 45296), Wydawca: Hindawi
    Status:
    Published
    DOI:
    10.1155/2013/814549 - link to the publication
  9. 5‑Azacytidine inhibits human rhabdomyosarcoma cell growth by downregulating insulin‑like growth factor 2 expression and reactivating the H19 gene product miR‑675, which negatively affects insulin‑like growth factors and insulin signaling
    Authors:
    Maciej Tarnowski, Marta Tkacz, Michał Czerewaty, Agata Poniewierska‑Baran, Katarzyna Grymuła, Mariusz Z. Ratajczak
    Academic press:
    International Journal of Oncology (rok: 2015, tom: 46(5), strony: 2241-50), Wydawca: International Center for Cancer Research; Ethnikon Hidryma Ereunōn (Greece), Spandidos Publications
    Status:
    Published
    DOI:
    10.3892/ijo.2015.2906 - link to the publication
  10. Bioactive Lipids S1P and C1P Are Prometastatic Factors in Human Rhabdomyosarcoma, and Their Tissue Levels Increase in Response to Radio/Chemotherapy
    Authors:
    Schneider G, Bryndza E, Abdel-Latif A, Ratajczak J, Maj M, Tarnowski M, Klyachkin YM, Houghton P, Morris AJ, Vater A, Klussmann S, Kucia M, Ratajczak MZ
    Academic press:
    Molecular Cancer Research (rok: 2013, tom: 11, strony: 793-807), Wydawca: American Association for Cancer Research
    Status:
    Published
    DOI:
    10.1158/1541-7786.MCR-12-0600 - link to the publication
  11. Bioactive lipids and cationic antimicrobial peptides as new potential regulators for trafficking of bone marrow-derived stem cells in patients with acute myocardial infarction
    Authors:
    Karapetyan AV, Klyachkin YM, Selim S, Sunkara M, Ziada KM, Cohen DA, Zuba-Surma EK, Ratajczak J, Smyth SS, Ratajczak MZ, Morris AJ, Abdel-Latif A.
    Academic press:
    Stem Cells And Development (rok: 2013, tom: 22 (11), strony: 1645-1656), Wydawca: Mary Ann Liebert
    Status:
    Published
    DOI:
    10.1089/scd.2012.0488 - link to the publication
  12. Downregulation of Heme Oxygenase 1 (HO-1) Activity in Hematopoietic Cells Enhances Their Engraftment After Transplantation.
    Authors:
    Adamiak M, Moore JB 4th, Zhao J, Abdelbaset-Ismail A, Grubczak K, Rzeszotek S, Wysoczynski M, Ratajczak MZ
    Academic press:
    Cell Transplantation (rok: 2016, tom: 25, strony: 1265-1276), Wydawca: Cognizant Communication Corporation
    Status:
    Published
    DOI:
    10.3727/096368915X688957 - link to the publication
  13. Expression of the erythropoietin receptor by germline-derived cells - further support for a potential developmental link between the germline and hematopoiesis
    Authors:
    Suszynska M, Poniewierska-Baran A, Gunjal P, Ratajczak J, Marycz K, Kakar SS, Kucia M, Ratajczak MZ
    Academic press:
    Journal of Ovarian Research (rok: 2014, tom: 7, strony: 66), Wydawca: BioMed Central
    Status:
    Published
    DOI:
    10.1186/1757-2215-7-66 - link to the publication
  14. Histological changes of testes in growth hormone transgenic mice with high plasma level of GH and Insulin-like Growth Factor-1
    Authors:
    Piotrowska K, Słuczanowska-Głąbowska S, Kucia M, Bartke A, Laszczyńska M, Ratajczak MZ
    Academic press:
    Folia Histochemica et Cytobiologica (rok: 2015, tom: 53, strony: 249-258), Wydawca: Via Medica
    Status:
    Published
    DOI:
    10.5603/fhc.a2015.0024 - link to the publication
  15. Human rhabdomyosarcoma cells express functional erythropoietin receptor: Potential therapeutic implications
    Authors:
    Agata Poniewierska-Baran, Malwina Suszynska, Wenyue Sun, Ahmed Abdelbaset-Ismail, Gabriela Schneider, Frederic G. Barr, Mariusz Z. Ratajczak
    Academic press:
    INTERNATIONAL JOURNAL OF ONCOLOGY (rok: 2015, tom: 47(5), strony: 1989-97), Wydawca: International Center for Cancer Research; Ethnikon Hidryma Ereunōn (Greece), Spandidos Publications
    Status:
    Published
    DOI:
    10.3892/ijo.2015.3184 - link to the publication
  16. New advances in stem cell research: practical implications for regenerative medicine
    Authors:
    Ratajczak MZ, Jadczyk T, Pędziwiatr D, Wojakowski W
    Academic press:
    Polish Archives of Internal Medicine (rok: 2014, tom: 124, strony: 417-426), Wydawca: Medycyna Praktyczna
    Status:
    Published
    DOI:
    brak - link to the publication
  17. Positive effects of prolonged caloric restriction on the population of very small embryonic-like stem cells - hematopoietic and ovarian implications
    Authors:
    Grymula K, Piotrowska K, Słuczanowska-Głąbowska S, Mierzejewska K, Tarnowski M, Tkacz M, Poniewierska-Baran A, Pędziwiatr D, Suszyńska E, Laszczyńska M, Ratajczak MZ
    Academic press:
    Journal of Ovarian Research (rok: 2014, tom: 7, strony: 68), Wydawca: BioMed Central
    Status:
    Published
    DOI:
    10.1186/1757-2215-7-68 - link to the publication
  18. The role of sphingosine-1 phosphate and ceramide-1 phosphate in trafficking of normal stem cells and malignant cells
    Authors:
    Ratajczak MZ, Suszynska M, Borkowska S, Ratajczak J, Schneider G.
    Academic press:
    Expert Opinion On Therapeutic Targets (rok: 2014, tom: 18, strony: 95-107), Wydawca: Informa
    Status:
    Published
    DOI:
    10.1517/14728222.2014.851671 - link to the publication
  19. Further evidence that paroxysmal nocturnal haemoglobinuria is a disorder of defective cell membrane lipid rafts
    Authors:
    Mariusz Z Ratajczak, Sylwia Borkowska, Kasia Mierzejewska, Magda Kucia, Ewa Mendek-Czajkowska, Malwina Suszynska, Vivek A Sharma, Andrzej Deptala, Wechao Song, Uwe Platzbecker, Loree Larratt, Anna Janowska-Wieczorek, Jarek Maciejewski and Janina Ratajczak
    Academic press:
    Journal of Cellular and Molecular Medicine (rok: 2015, tom: 19(9), strony: 2193-201), Wydawca: John Wiley & Sons Ltd
    Status:
    Published
    DOI:
    10.1111/jcmm.12605 - link to the publication
  20. Hematopoietic Stem/Progenitor Cells Express Several Functional Sex Hormone Receptors—Novel Evidence for a Potential Developmental Link Between Hematopoiesis and Primordial Germ Cells
    Authors:
    Mierzejewska Katarzyna, Borkowska Sylwia, Suszynska Ewa, Suszynska Malwina, Poniewierska-Baran Agata, Maj Magda, Pedziwiatr Daniel, Adamiak Mateusz, Abdel-Latif Ahmed, Kakar Sham S., Ratajczak Janina, Kucia Magda, and Ratajczak Mariusz Z Ratajczak
    Academic press:
    Stem Cells and Development (rok: 2015, tom: 24(8), strony: 927-37), Wydawca: Mary Ann Liebert, Inc.
    Status:
    Published
    DOI:
    10.1089/scd.2014.0546 - link to the publication
  21. Mobilization studies in C3-deficient mice unravel the involvement of a novel crosstalk between the coagulation and complement cascades in mobilization of hematopoietic stem/progenitor cells
    Authors:
    Borkowska S, Suszynska M, Wysoczynski M, Ratajczak MZ
    Academic press:
    Leukemia (rok: 2013, tom: 27, strony: 1928-1930), Wydawca: Springer Nature
    Status:
    Published
    DOI:
    10.1038/leu.2013.84 - link to the publication
  22. Mobilization studies in C3-deficient mice unravel the involvement of a novel crosstalk between the coagulation and complement cascades in mobilization of hematopoietic stem/progenitor cells
    Authors:
    Borkowska S, Suszynska M, Wysoczynski M, Ratajczak MZ.
    Academic press:
    Leukemia (rok: 2013, tom: 27 (9), strony: 1928-30), Wydawca: Macmillan Publishers Limited
    Status:
    Published
    DOI:
    10.1038/leu.2013.84 - link to the publication
  23. Paracrine proangiopoietic effects of human umbilical cord blood-derived purified CD133+ cells--implications for stem cell therapies in regenerative medicine
    Authors:
    Ratajczak J, Kucia M, Mierzejewska K, Marlicz W, Pietrzkowski Z, Wojakowski W, Greco NJ, Tendera M, Ratajczak MZ
    Academic press:
    Stem Cells and Development (rok: 2013, tom: 22, strony: 422-430), Wydawca: Mary Ann Liebert
    Status:
    Published
    DOI:
    10.1089/scd.2012.0268 - link to the publication
  24. The role of bioactive lipids in stem cell mobilization and homing: novel therapeutics for myocardial ischemia
    Authors:
    Klyachkin YM, Karapetyan AV, Ratajczak MZ, Abdel-Latif A
    Academic press:
    BioMed Research International (rok: 2014, tom: 2014, strony: 653543), Wydawca: Hindawi
    Status:
    Published
    DOI:
    10.1155/2014/653543 - link to the publication
  25. An emerging link in stem cell mobilization between activation of the complement cascade and the chemotactic gradient of sphingosine-1-phosphate
    Authors:
    Ratajczak MZ, Borkowska S, Ratajczak J.
    Academic press:
    Prostaglandins & Other Lipid Mediators (rok: 2013, tom: 104, strony: 122-129), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.prostaglandins.2012.07.003 - link to the publication
  26. Badania nad komórkami macierzystymi i ich rosnący wpływ na współczesną psychiatrię.
    Authors:
    Ratajczak MZ, Kucharska-Mazur J, Samochowiec J
    Academic press:
    Psychiatria Polska (rok: 2014, tom: 48, strony: 1073-1085), Wydawca: Komitet Redakcyjno-Wydawniczy Polskiego Towarzystwa Psychiatrycznego
    Status:
    Published
    DOI:
    brak - link to the publication
  27. Bioactive Lipids, LPC and LPA, Are Novel Prometastatic Factors and Their Tissue Levels Increase in Response to Radio/Chemotherapy
    Authors:
    Gabriela Schneider, Zachariah Payne Sellers, Ahmed Abdel-Latif, Andrew J. Morris, Mariusz Z. Ratajczak
    Academic press:
    Molecular Cancer Research (rok: 2014, tom: 12(11), strony: 1560-73), Wydawca: American Association for Cancer Research
    Status:
    Published
    DOI:
    10.1158/1541-7786.MCR-14-0188 - link to the publication
  28. Endurance Exercise Mobilizes Developmentally Early Stem Cells into Peripheral Blood and Increases Their Number in Bone Marrow: Implications for Tissue Regeneration
    Authors:
    Marycz K, Mierzejewska K, Śmieszek A, Suszynska E, Malicka I, Kucia M, Ratajczak MZ
    Academic press:
    Stem Cells International (rok: 2016, tom: 5756901, strony: 45301), Wydawca: Hindawi
    Status:
    Published
    DOI:
    10.1155/2016/5756901 - link to the publication
  29. Evidence of a Pivotal Role for the Distal Part of the Complement Cascade in the Diurnal Release of Hematopoietic Stem Cells Into Peripheral Blood.
    Authors:
    Borkowska S, Suszynska M, Ratajczak J, Ratajczak MZ
    Academic press:
    Cell Transplantation (rok: 2016, tom: 25, strony: 275-282), Wydawca: Cognizant Communication Corporation
    Status:
    Published
    DOI:
    10.3727/096368915X688489 - link to the publication
  30. Evidence that vitronectin is a potent migration-enhancing factor for cancer cells chaperoned by fibrinogen: a novel view of the metastasis of cancer cells to low-fibrinogen lymphatics and body cavities
    Authors:
    Schneider G, Bryndza E, Poniewierska-Baran A, Serwin K, Suszynska M, Sellers ZP, Merchant ML, Kaliappan A, Ratajczak J, Kucia M, Garbett NC, Ratajczak MZ
    Academic press:
    Oncotarget (rok: 2016, tom: 43, strony: 69829-69843), Wydawca: Impact Journals
    Status:
    Published
    DOI:
    10.18632/oncotarget.12003 - link to the publication
  31. Horizontal transfer of RNA and proteins between cells by extracellular microvesicles: 14 years later
    Authors:
    Ratajczak MZ, Ratajczak J
    Academic press:
    Clinical and Translational Medicine (rok: 2016, tom: 5, strony: 7), Wydawca: SpringerOpen
    Status:
    Published
    DOI:
    10.1186/s40169-016-0087-4 - link to the publication
  32. Human rhabdomyosarcoma cells express functional pituitary and gonadal sex hormone receptors: Therapeutic implications
    Authors:
    PONIEWIERSKA-BARAN A, SCHNEIDER G, SUN W, ABDELBASET-ISMAIL A, BARR FG, RATAJCZAK MZ
    Academic press:
    International Journal of Oncology (rok: 2016, tom: 48, strony: 1815-1824), Wydawca: Spandidos Publications
    Status:
    Published
    DOI:
    10.3892/ijo.2016.3439 - link to the publication
  33. Parental imprinting regulates insulin-like growth factor signaling: a Rosetta Stone for understanding the biology of pluripotent stem cells, aging and cancerogenesis
    Authors:
    Ratajczak MZ, Shin DM, Schneider G, Ratajczak J, Kucia M
    Academic press:
    Leukemia (rok: 2013, tom: 27, strony: 773-779), Wydawca: Springer Nature
    Status:
    Published
    DOI:
    10.1038/leu.2012.322 - link to the publication
  34. The effect of low and high plasma levels of insulin-like growth factor-1 (IGF-1) on the morphology of major organs: studies of Laron dwarf and bovine growth hormone transgenic (bGHTg) mice
    Authors:
    Piotrowska K, Borkowska SJ, Wiszniewska B, Laszczyńska M, Słuczanowska-Głabowska S, Havens AM, Kopchick JJ, Bartke A, Taichman RS, Kucia M, Ratajczak MZ.
    Academic press:
    Histology and Histopathology (rok: 2013, tom: 28, strony: 1325-1336), Wydawca: Murcia
    Status:
    Published
    DOI:
    brak - link to the publication

O Narodowym Centrum Nauki

Finansowanie nauki

Współpraca zagraniczna

Centrum prasowe

Deklaracja dostępności
Przetwarzanie danych osobowych
Polityka cookies

Partnerzy