Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

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Mechanism of connective tissue deficiences in hyperhomocysteinemia

2011/02/A/NZ1/00010

Keywords:

homocysteine elastin colagen desmosine

Descriptors:

  • NZ1_1: Molecular biology
  • NZ1_2: Biochemistry

Panel:

NZ1 - Molecular biology, structural biology, biotechnology: molecular biology, structural biology, biotechnology

Host institution :

Uniwersytet Przyrodniczy w Poznaniu, Wydział Rolnictwa i Bioinżynierii

woj. wielkopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Hieronim Jakubowski 

Number of co-investigators in the project: 6

Call: MAESTRO 1 - announced on 2011-06-15

Amount awarded: 1 799 421 PLN

Project start date (Y-m-d): 2012-04-30

Project end date (Y-m-d): 2015-04-30

Project duration:: 36 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. Termostatowana wytrząsarka mikropłytkowa.
  2. Automatyczna płuczka do płytek ELISA.
  3. Pompa przepływowa do HPLC.
  4. Wirówka próżniowa (73 277 PLN)
  5. Zestaw do derywatyzacji postkolumnowej (98 400 PLN)
  6. System indywidualnie wentylowanych klatek dla myszy z regałem i akcesoriami oraz stacją wymiany klatek.
  7. Aparat do ogniskowania izoelektrycznego i elektoroforezy z zasilaczem.
  8. System UHPLC (450 000 PLN)
  9. Termowytrząsarka.
  10. Urządzenie do pomiaru stężenia siarkowodoru (6 888 PLN)

Information in the final report

  • Publication in academic press/journals (15)
  • Articles in post-conference publications (3)
  1. Bleomycin hydrolase and hyperhomocysteinemia modulate the expression of mouse proteins involved in liver homeostasis
    Authors:
    Suszyńska-Zajczyk J, Wróblewski J, Utyro O, Łuczak M, Marczak Ł, Jakubowski H.
    Academic press:
    Amino Acids (rok: 2014, tom: 46, strony: 1471-80), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s00726-014-1712-4 - link to the publication
  2. Methionine-induced hyperhomocysteinemia and bleomycin hydrolase deficiency alter the expression of mouse kidney proteins involved in renal disease
    Authors:
    Suszyńska-Zajczyk J, Utyro O, Jakubowski H.
    Academic press:
    Mol Genet Metab (rok: 2014, tom: 4,66666666666667, strony: 339-46), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.ymgme.2014.05.010 - link to the publication
  3. Paraoxonase 1 deficiency and hyperhomocysteinemia alter the expression of mouse kidney proteins involved in renal disease
    Authors:
    Suszyńska-Zajczyk J, Sikora M, Jakubowski H.
    Academic press:
    Mol Genet Metab (rok: 2014, tom: 113, strony: Mol Genet Metab), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.ymgme.2014.07.011 - link to the publication
  4. Identification of N-homocysteinylation sites in plasma proteins
    Authors:
    Sikora M, Marczak Ł, Kubalska J, Graban A, Jakubowski H.
    Academic press:
    Amino Acids (rok: 2014, tom: 46, strony: 235-44), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s00726-013-1617-7 - link to the publication
  5. The Mechanism and Consequences of Homocysteine Incorporation Into Protein in Humans
    Authors:
    Jakubowski H.
    Academic press:
    Phosphorus, Sulfur, and Silicon and the Related Elements (rok: 2013, tom: 188, strony: 384-395), Wydawca: Taylor & Francis
    Status:
    Published
    DOI:
    10.1080/10426507.2012.736104 - link to the publication
  6. Aminoacyl-tRNA Synthetases and the Evolution of Coded Peptide Synthesis: The Thioester World.
    Authors:
    Jakubowski H.
    Academic press:
    FEBS Lett. (rok: 2016, tom: 590, strony: 469-81), Wydawca: Wiley
    Status:
    Published
    DOI:
    10.1002/1873-3468.12085 - link to the publication
  7. N-Homocysteinylation impairs collagen cross-linking in cystathionine β-synthase-deficient mice: a novel mechanism of connective tissue abnormalities
    Authors:
    Perła-Kajan J, Utyro O, Rusek M, Malinowska A, Sitkiewicz E, Jakubowski H.
    Academic press:
    FASEB J (rok: 2016, tom: 30, strony: 3810-21), Wydawca: Federation of American Societies for Experimental Biology
    Status:
    Published
    DOI:
    10.1096/fj.201600539 - link to the publication
  8. Paraoxonase 1 deficiency and dietary hyperhomocysteinemia modulate the expression of mouse proteins involved in liver homeostasis
    Authors:
    Suszyńska-Zajczyk J, Jakubowski H.
    Academic press:
    Acta Biochim Pol (rok: 2014, tom: 61, strony: 815-23), Wydawca: Polskie Towarzystwo Biochemiczne i Komitet Biochemii i Biofizyki PAN
    Status:
    Published
    DOI:
    brak - link to the publication
  9. Homocysteine-Thiolactone and N-Homocysteinylated Protein Induce Pro-atherogenic Changes in Gene Expression in Human Vascular Endothelial Cells
    Authors:
    Gurda D, Handshuch L, Kotkowiak W, Jakubowski H.
    Academic press:
    Amino Acids (rok: 2015, tom: 47, strony: 1319-39), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s00726-015-1956-7 - link to the publication
  10. Hyperhomocysteinemia and bleomycin hydrolase modulate the expression of mouse brain proteins involved in neurodegeneration
    Authors:
    Suszyńska-Zajczyk J, Łuczak M, Marczak Ł, Jakubowski H.
    Academic press:
    J Alzheimer's Dis (rok: 2013, tom: 40, strony: 713-26), Wydawca: IOS Press
    Status:
    Published
    DOI:
    10.3233/JAD-132033 - link to the publication
  11. The nomenclature of 1-aminoalkylphosphonic acids and derivatives: evolution of the code system
    Authors:
    Drabowicz J, Jakubowski H, Kudzin MH, Kudzin ZH.
    Academic press:
    Acta Biochim Pol (rok: 2015, tom: 62, strony: 139-50), Wydawca: Polskie Towarzystwo Biochemiczne i Komitet Biochemii i Biofizyki PAN
    Status:
    Published
    DOI:
    brak - link to the publication
  12. l-Arginine and vitamin C attenuate pro-atherogenic effects of high-fat diet on biomarkers of endothelial dysfunction in rats
    Authors:
    Bogdański P, Suliburska J, Szulińska M, Sikora M, Walkowiak J, Jakubowski H.
    Academic press:
    Biomedicine Pharmacotherapy (rok: 2015, tom: 76, strony: 100-106), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.001 - link to the publication
  13. Identification of N-homocysteinylation sites in plasma proteins
    Authors:
    Sikora M, Marczak Ł, Kubalska J, Graban A, Jakubowski H.
    Academic press:
    Amino Acids (rok: 2014, tom: 46, strony: 235-244), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s00726-013-1617-7 - link to the publication
  14. Inactivation of the Paraoxonase 1 Gene Affects the Expression of Mouse Brain Proteins Involved in Neurodegeneration
    Authors:
    Suszyńska-Zajczyk J, Luczak M, Marczak L, Jakubowski H.
    Academic press:
    J Alzheimers Dis (rok: 2014, tom: 42, strony: 247-260), Wydawca: IOS Press
    Status:
    Published
    DOI:
    10.3233/JAD-132714 - link to the publication
  15. Paraoxonase 1 and homocysteine metabolism
    Authors:
    Perła-Kaján J, Jakubowski H.
    Academic press:
    Amino Acids (rok: 2012, tom: 43, strony: 1405-17), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s00726-012-1321-z - link to the publication
  1. The mechanism and consequences of homocysteine incorporation into protein in humans
    Authors:
    Jakubowski H.
    Conference:
    25th International Symposium on the Organic Chemistry of Sulfur (rok: 2012, ), Wydawca: Taylor & Francis
    Data:
    konferencja 24-29.06.2012
    Status:
    Published
    DOI:
    link to the publication
  2. Tissue-specific effect of hyperhomocysteinemia on collagen and elastin cross-links in a cystathionine beta-synthase-deficient mouse
    Authors:
    Perla-Kajan, J, Ogrodna, K, Jakubowski H.
    Conference:
    14th International Congress on Amino Acids, Peptides and Protein (rok: 2016, ), Wydawca: Amino Acids, Springer
    Data:
    konferencja 3-7.08.2015
    Status:
    Published
  3. Major Urinary Protein Levels In Cystathionine Beta β-Synthase- Deficient Mice
    Authors:
    Perła-Kaján J, Wróblewski J, Jakubowski H.
    Conference:
    9th International Conference on Homocysteine and One-carbon Metabolism – HCY2013, Trinity College Dublin, Ireland (rok: 2013, ), Wydawca: J Inherit Metab Dis, Springer
    Data:
    konferencja 8-12.09.2013
    Status:
    Published

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