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Mechanism of connective tissue deficiences in hyperhomocysteinemia

2011/02/A/NZ1/00010

Keywords

Descriptors

  • NZ1_1: Biologia molekularna
  • NZ1_2: Biochemia

Panel

NZ1 – Molecular biology, structural biology, biotechnology: molecular biology, structural biology, biotechnology

Host institution

Uniwersytet Przyrodniczy w Poznaniu, Wydział Rolnictwa i Bioinżynierii

Voivodeship: wielkopolskie

Other projects carried out by the institution »

Principal investigator (from the host institution)

prof. Hieronim Jakubowski

Number of co-investigators in the project: 6

Call

MAESTRO 1 – announced on 2011-06-15

Amount awarded
1 799 421 PLN
Project start date
2012-04-30
Project end date
2015-04-30
Project duration
36 months (the same as in the proposal)
Project status
Project settled

Equipment purchased [PL]

  1. Aparat do ogniskowania izoelektrycznego i elektoroforezy z zasilaczem.
  2. Automatyczna płuczka do płytek ELISA.
  3. Pompa przepływowa do HPLC.
  4. System UHPLC. Cost: 450 000 PLN
  5. System indywidualnie wentylowanych klatek dla myszy z regałem i akcesoriami oraz stacją wymiany klatek.
  6. Termostatowana wytrząsarka mikropłytkowa.
  7. Termowytrząsarka.
  8. Urządzenie do pomiaru stężenia siarkowodoru. Cost: 6 888 PLN
  9. Wirówka próżniowa. Cost: 73 277 PLN
  10. Zestaw do derywatyzacji postkolumnowej. Cost: 98 400 PLN

Information in the final report

Publication in academic press/journals (14)

  1. Paraoxonase 1 deficiency and dietary hyperhomocysteinemia modulate the expression of mouse proteins involved in liver homeostasis

    Authors:
    Suszyńska-Zajczyk J, Jakubowski H.
    Academic press:
    Acta Biochim Pol (year: 2014, volume: 61, pages: 815-23), Publisher: Polskie Towarzystwo Biochemiczne i Komitet Biochemii i Biofizyki PAN
    Status:
    Published

  2. Identification of N-homocysteinylation sites in plasma proteins

    Authors:
    Sikora M, Marczak Ł, Kubalska J, Graban A, Jakubowski H.
    Academic press:
    Amino Acids (year: 2014, volume: 46, pages: 235-244), Publisher: Springer
    Status:
    Published
    DOI:
    10.1007/s00726-013-1617-7 – link to the publication

  3. Homocysteine-Thiolactone and N-Homocysteinylated Protein Induce Pro-atherogenic Changes in Gene Expression in Human Vascular Endothelial Cells

    Authors:
    Gurda D, Handshuch L, Kotkowiak W, Jakubowski H.
    Academic press:
    Amino Acids (year: 2015, volume: 47, pages: 1319-39), Publisher: Springer
    Status:
    Published
    DOI:
    10.1007/s00726-015-1956-7 – link to the publication

  4. Paraoxonase 1 and homocysteine metabolism

    Authors:
    Perła-Kaján J, Jakubowski H.
    Academic press:
    Amino Acids (year: 2012, volume: 43, pages: 1405-17), Publisher: Springer
    Status:
    Published
    DOI:
    10.1007/s00726-012-1321-z – link to the publication

  5. The Mechanism and Consequences of Homocysteine Incorporation Into Protein in Humans

    Authors:
    Jakubowski H.
    Academic press:
    Phosphorus, Sulfur, and Silicon and the Related Elements (year: 2013, volume: 188, pages: 384-395), Publisher: Taylor & Francis
    Status:
    Published
    DOI:
    10.1080/10426507.2012.736104 – link to the publication

  6. Bleomycin hydrolase and hyperhomocysteinemia modulate the expression of mouse proteins involved in liver homeostasis

    Authors:
    Suszyńska-Zajczyk J, Wróblewski J, Utyro O, Łuczak M, Marczak Ł, Jakubowski H.
    Academic press:
    Amino Acids (year: 2014, volume: 46, pages: 1471-80), Publisher: Springer
    Status:
    Published
    DOI:
    10.1007/s00726-014-1712-4 – link to the publication

  7. Hyperhomocysteinemia and bleomycin hydrolase modulate the expression of mouse brain proteins involved in neurodegeneration

    Authors:
    Suszyńska-Zajczyk J, Łuczak M, Marczak Ł, Jakubowski H.
    Academic press:
    J Alzheimer's Dis (year: 2013, volume: 40, pages: 713-26), Publisher: IOS Press
    Status:
    Published
    DOI:
    10.3233/JAD-132033 – link to the publication

  8. Paraoxonase 1 deficiency and hyperhomocysteinemia alter the expression of mouse kidney proteins involved in renal disease

    Authors:
    Suszyńska-Zajczyk J, Sikora M, Jakubowski H.
    Academic press:
    Mol Genet Metab (year: 2014, volume: 113, pages: Mol Genet Metab), Publisher: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.ymgme.2014.07.011 – link to the publication

  9. The nomenclature of 1-aminoalkylphosphonic acids and derivatives: evolution of the code system

    Authors:
    Drabowicz J, Jakubowski H, Kudzin MH, Kudzin ZH.
    Academic press:
    Acta Biochim Pol (year: 2015, volume: 62, pages: 139-50), Publisher: Polskie Towarzystwo Biochemiczne i Komitet Biochemii i Biofizyki PAN
    Status:
    Published

  10. l-Arginine and vitamin C attenuate pro-atherogenic effects of high-fat diet on biomarkers of endothelial dysfunction in rats

    Authors:
    Bogdański P, Suliburska J, Szulińska M, Sikora M, Walkowiak J, Jakubowski H.
    Academic press:
    Biomedicine Pharmacotherapy (year: 2015, volume: 76, pages: 100-106), Publisher: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.biopha.2015.10.001 – link to the publication

  11. Aminoacyl-tRNA Synthetases and the Evolution of Coded Peptide Synthesis: The Thioester World.

    Authors:
    Jakubowski H.
    Academic press:
    FEBS Lett. (year: 2016, volume: 590, pages: 469-81), Publisher: Wiley
    Status:
    Published
    DOI:
    10.1002/1873-3468.12085 – link to the publication

  12. Inactivation of the Paraoxonase 1 Gene Affects the Expression of Mouse Brain Proteins Involved in Neurodegeneration

    Authors:
    Suszyńska-Zajczyk J, Luczak M, Marczak L, Jakubowski H.
    Academic press:
    J Alzheimers Dis (year: 2014, volume: 42, pages: 247-260), Publisher: IOS Press
    Status:
    Published
    DOI:
    10.3233/JAD-132714 – link to the publication

  13. Methionine-induced hyperhomocysteinemia and bleomycin hydrolase deficiency alter the expression of mouse kidney proteins involved in renal disease

    Authors:
    Suszyńska-Zajczyk J, Utyro O, Jakubowski H.
    Academic press:
    Mol Genet Metab (year: 2014, volume: 4,66666666666667, pages: 339-46), Publisher: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.ymgme.2014.05.010 – link to the publication

  14. N-Homocysteinylation impairs collagen cross-linking in cystathionine β-synthase-deficient mice: a novel mechanism of connective tissue abnormalities

    Authors:
    Perła-Kajan J, Utyro O, Rusek M, Malinowska A, Sitkiewicz E, Jakubowski H.
    Academic press:
    FASEB J (year: 2016, volume: 30, pages: 3810-21), Publisher: Federation of American Societies for Experimental Biology
    Status:
    Published
    DOI:
    10.1096/fj.201600539 – link to the publication

Articles in post-conference publications (3)

  1. Major Urinary Protein Levels In Cystathionine Beta β-Synthase- Deficient Mice

    Authors:
    Perła-Kaján J, Wróblewski J, Jakubowski H.
    Conference:
    9th International Conference on Homocysteine and One-carbon Metabolism – HCY2013, Trinity College Dublin, Ireland (year: 2013, pages: 36(Suppl 1):S39), Publisher: J Inherit Metab Dis, Springer
    Date:
    conference 8-12.09.2013
    Status:
    Published

  2. Tissue-specific effect of hyperhomocysteinemia on collagen and elastin cross-links in a cystathionine beta-synthase-deficient mouse

    Authors:
    Perla-Kajan, J, Ogrodna, K, Jakubowski H.
    Conference:
    14th International Congress on Amino Acids, Peptides and Protein (year: 2016, pages: 48(2):635-635), Publisher: Amino Acids, Springer
    Date:
    conference 3-7.08.2015
    Status:
    Published

  3. The mechanism and consequences of homocysteine incorporation into protein in humans

    Authors:
    Jakubowski H.
    Conference:
    25th International Symposium on the Organic Chemistry of Sulfur (year: 2012, pages: 384-395), Publisher: Taylor & Francis
    Date:
    conference 24-29.06.2012
    Status:
    Published
    DOI:
    link to the publication

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