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The role of inflammatory and anti-inflammatory cytokines in the process of epileptogenesis and their interaction with inhibitory neurotransmitters.

2011/01/B/NZ4/04909

Keywords:

kindling of seizures inflammatory processes cytokines inhibitory neurotransmitters

Descriptors:

  • NZ4_17:

Panel:

NZ4 - Biology of tissues, organs and organisms: morphology and functions of animal's and human's systems, organs and organisms, experimental medicine, basics of neurology

Host institution :

Instytut Psychiatrii i Neurologii

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Piotr Maciejak 

Number of co-investigators in the project: 6

Call: OPUS 1 - announced on 2011-03-15

Amount awarded: 321 600 PLN

Project start date (Y-m-d): 2011-12-16

Project end date (Y-m-d): 2015-06-15

Project duration:: 42 months (the same as in the proposal)

Project status: Project settled

Information in the final report

  • Publication in academic press/journals (6)
  1. The kynurenine pathway: a missing piece in the puzzle of valproate action?
    Authors:
    Maciejak P, Szyndler J, Turzyńska D, Sobolewska A, Kołosowska K, Lehner M, Płaźnik A.
    Academic press:
    Neuroscience (rok: 2013, tom: 27;234, strony: 135-145), Wydawca: ELSEVIER
    Status:
    Published
    DOI:
    10.1016/j.neuroscience.2012.12.052 - link to the publication
  2. The role of interleukin-1β in the pentylenetetrazole-induced kindling of seizures, in the rat hippocampus.
    Authors:
    Kołosowska K, Maciejak P, Szyndler J, Turzyńska D, Sobolewska A, Płaźnik A.
    Academic press:
    Eur J Pharmacol (rok: 2014, tom: 15;731, strony: 31-37), Wydawca: ELSEVIER
    Status:
    Published
    DOI:
    10.1016/j.ejphar.2014.03.008 - link to the publication
  3. The role of IL-1β and glutamate in the effects of lipopolysaccharide on the hippocampal electrical kindling of seizures
    Authors:
    Kołosowska K., Maciejak P., Szyndler J., Turzyńska D., Sobolewska A., Płaźnik A.
    Academic press:
    Journal of Neuroimmunology (rok: 2016, tom: 298, strony: 146-152), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.jneuroim.2016.07.018 - link to the publication
  4. Changes in the Egr1 and Arc expression in brain structures of pentylenetetrazole-kindled rats.
    Authors:
    Szyndler J, Maciejak P, Wisłowska-Stanek A, Lehner M, Płaźnik A.
    Academic press:
    Pharmacol Rep. (rok: 2013, tom: 65(2), strony: 368-378), Wydawca: Instytut Faramkologii PAN
    Status:
    Published
    DOI:
    brak - link to the publication
  5. Is the interaction between fatty acids and tryptophan responsible for the efficacy of a ketogenic diet in epilepsy? The new hypothesis of action.
    Authors:
    Maciejak P, Szyndler J, Turzyńska D, Sobolewska A, Kołosowska K, Krząścik P, Płaźnik A.
    Academic press:
    Neuroscience (rok: 2016, tom: 28;313, strony: 130-48), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.neuroscience.2015.11.029 - link to the publication
  6. Valproate Disturbs the Balance Between Branched and Aromatic Amino Acids in Rats.
    Authors:
    Maciejak P, Szyndler J, Kołosowska K, Turzyńska D, Sobolewska A, Walkowiak J, Płaźnik A.
    Academic press:
    Neurotox Res. (rok: 2013, tom: brak, strony: brak), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s12640-013-9441-0 - link to the publication

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