Evaluation of the pertussis toxin level produced in vitro in respect to the alleles of promoter of gene encoding pertussis toxin ptxP as factor increasing the virulence of Bordetella pertussis strains potentially responsible for epidemic increase of pertussis cases in Poland

2011/01/N/NZ7/05305

Keywords

Descriptors

  • NZ7_3: Promocja zdrowia, kultura fizyczna
  • NZ7_1: Epidemiologia

Panel

NZ7 – Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology

Host institution

Narodowy Instytut Zdrowia Publicznego - Państwowy Zakład Higieny (NIZP - PZH)

Voivodeship: mazowieckie

Other projects carried out by the institution »

Principal investigator (from the host institution)

Monika Zawadka

Number of co-investigators in the project: 4

Call

PRELUDIUM 1 – announced on 2011-03-15

Amount awarded
136 600 PLN
Project start date
2011-12-13
Project end date
2014-01-12
Project duration
25 months (the same as in the proposal)
Project status
Project settled

Equipment purchased [PL]

  1. Wirówka z chłodzeniem z adapterem do wirowania probówek typu Eppendorf i próbówek typu falcon. Cost: 30 000 PLN

Information in the final report

Publication in academic press/journals (4)

  1. Ocena toksyczności szczepów Bordetella pertussis z zastosowaniem linii komórkowych CHO in vitro

    Authors:
    Zawadka M., Rabczenko D., Lutyńska A.
    Academic press:
    Medycyna Doświadczalna i Mikrobiologia (year: 2014, volume: 66, pages: 185-194), Publisher: Narodowy Instytut Zdrowia Publicznego - Państwowy Zakład Higieny,
    Status:
    Published
  2. Consistency of Bordetella pertussis vaccine seed strains and potency of whole-cell pertussis vaccine still in use in Poland

    Authors:
    Zawadka M., Mosiej E., Polak M.,, Krysztopa-Grzybowska K., Moskała B., Rokosz-Chudziak N., Rabczenko D., Augustynowicz E., Lutyńska A.
    Academic press:
    Biologicals (year: 2014, volume: 42, pages: 123-127), Publisher: ELSEVIER
    Status:
    Published
    DOI:
    10.1016/j.biologicals.2013.11.006 – link to the publication
  3. Badanie genetycznej zmienności szczepów Bordatella pertussis w aspekcie wzrostu zachorowań na krztusiec

    Authors:
    Lutyńska A., Mosiej E., Zawadka M., Polak M., Augustynowicz E
    Academic press:
    Problemy Higieny i Epidemiologii (year: 2012, volume: 3, pages: 599-604), Publisher: Polskie Towarzystwo Higieniczne
    Status:
    Published
  4. Sequence variation in virulence-related genes of Bordetella pertussis isolates from Poland in the period 1959-2013

    Authors:
    Mosiej E., Zawadka M., Krysztopa-Grzybowska K., Polak M., Augustynowicz E., Piekarska K., Lutyńska A
    Academic press:
    Eur J Clin Microbiol Infect Dis (year: 2015, volume: 34, pages: 147-152), Publisher: Springer
    Status:
    Published
    DOI:
    10.1007/s10096-014-2216-6 – link to the publication

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