Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

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In vitro and in vivo study of bioavailability and metabolism of selected genistein derivatives exhibiting antitumor potential

2011/01/N/NZ4/01141

Keywords:

bioavailability metabolism genistein derivatives

Descriptors:

  • NZ4_18:
  • ST4_6: Instrumental methods in chemistry

Panel:

NZ4 - Biology of tissues, organs and organisms: morphology and functions of animal's and human's systems, organs and organisms, experimental medicine, basics of neurology

Host institution :

Politechnika Śląska, Wydział Chemiczny

woj. śląskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

Katarzyna Papaj 

Number of co-investigators in the project: 2

Call: PRELUDIUM 1 - announced on 2011-03-15

Amount awarded: 90 000 PLN

Project start date (Y-m-d): 2011-12-19

Project end date (Y-m-d): 2014-12-18

Project duration:: 36 months (the same as in the proposal)

Project status: Project settled

Information in the final report

  • Publication in academic press/journals (3)
  1. Genistein Derivatives Regioisomerically Substituted at 7-O- and 4′-O- Have Different Effect on the Cell Cycle
    Authors:
    A. Byczek, J. Zawisza-Puchalka, A. Gruca, K. Papaj, G. Grynkiewicz, M. Rusin, W. Szeja, A. Rusin
    Academic press:
    Journal of Chemistry (rok: 2013, tom: ID 191563, strony: 12 pages), Wydawca: Hindawi Publishing Corporation
    Status:
    Published
    DOI:
    10.1155/2013/191563 - link to the publication
  2. Absorption and metabolism of biologically active genistein derivatives in colon carcinoma cell line (Caco-2)
    Authors:
    Katarzyna Papaj, Aleksandra Rusin, Wiesław Szeja
    Academic press:
    Acta Poloniae Pharmaceutica -Drug Research (rok: 2014, tom: 71 (6), strony: 1037-1044), Wydawca: Polskie Towarzystwo Farmaceutyczne
    Status:
    Published
    DOI:
    brak - link to the publication
  3. Synthesis and Cytotoxicity of 2,3-Enopyranosyl C-Linked Conjugates of Genistein
    Authors:
    Wieslaw Szeja, Grzegorz Grynkiewicz, Tadeusz Bieg, Piotr Swierk, Anna Byczek, Katarzyna Papaj, Radosław Kitel, Aleksandra Rusin
    Academic press:
    Molecules (rok: 2014, tom: 19(6), strony: 7072-7093), Wydawca: MDPI - Open Access Publishing
    Status:
    Published
    DOI:
    10.3390/molecules19067072 - link to the publication

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