Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Evaluation of immunomodulatory role of glycolipids in autoimmune demyelinization.

2011/01/N/NZ4/04962

Keywords:

Multiple sclerosis sulfatides cerebrosides T cell antigen presenting cells IL10 CXCR4

Descriptors:

  • NZ4_9: Systems neurobiology
  • NZ4_7: Neurophysiology
  • NZ4_4: Pathophysiology

Panel:

NZ4 - Biology of tissues, organs and organisms: morphology and functions of animal's and human's systems, organs and organisms, experimental medicine, basics of neurology

Host institution :

Uniwersytet Medyczny w Łodzi, Wydział Lekarski

woj. łódzkie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Beata Śliwińska 

Number of co-investigators in the project: 2

Call: PRELUDIUM 1 - announced on 2011-03-15

Amount awarded: 200 000 PLN

Project start date (Y-m-d): 2012-04-04

Project end date (Y-m-d): 2015-04-03

Project duration:: 36 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. Inkubator do sterylnych hodowli komórkowych.
  2. Mini wirówka z chłodzeniem (50 000 PLN)

Information in the final report

  • Publication in academic press/journals (2)
  • Articles in post-conference publications (2)
  1. Plasmocytoid dendritic cell deficit of early response to toll-like receptor 7 agonist stimulation in multiple sclerosis patients.
    Authors:
    Mycko MP, Cwiklinska H, Cichalewska M, Matysiak M, Lewkowicz P, Sliwinska B, Selmaj I, Selmaj KW
    Academic press:
    Clinical Immunology (rok: 2014, tom: 153, strony: 211-219), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.clim.2014.04.016. - link to the publication
  2. Brain glycolipids suppress T helper cells and inhibit autoimmune demyelination.
    Authors:
    Mycko MP, Sliwinska B, Cichalewska M, Cwiklinska H, Raine CS, Selmaj KW
    Academic press:
    The Journal of Neuroscience (rok: 2014, tom: 34, strony: 8646-8658), Wydawca: Society for Neuroscience
    Status:
    Published
    DOI:
    10.1523/JNEUROSCI.0885-14.2014. - link to the publication
  1. microRNA-155 regulates T helper cell autoimmunity during autoimmune demyelination via Hsp40 genes expression
    Authors:
    Maria Cichalewska, Marcin P. Mycko, Hanna Cwiklinska, Beata Sliwinska, Krzysztof W. Selmaj
    Conference:
    29th Congress of the European-Committee-for-Treatment-and-Research-in-Multiple-Sclerosis / 18th Annual Conference of Rehabilitation in MS (rok: 2013, ), Wydawca: MULTIPLE SCLEROSIS JOURNAL
    Data:
    konferencja 02-05.10.2013
    Status:
    Published
  2. Myelin sulfatides maintenance of an T cell immunity during autoimmune demyelination
    Authors:
    Marcin P. Mycko, Beata Sliwinska, Maria Cichalewska, Hanna Cwiklinska, Krzysztof W. Selmaj
    Conference:
    29th Congress of the European-Committee-for-Treatment-and-Research-in-Multiple-Sclerosis / 18th Annual Conference of Rehabilitation in MS (rok: 2013, ), Wydawca: MULTIPLE SCLEROSIS JOURNAL
    Data:
    konferencja 02-05.10.2013
    Status:
    Published

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