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Information on the principal investigator and host institution

Information of the project and the call

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Molecular basis of selective toxicity of N-substituted derivatives of an antifungal antibiotic Nystatin A1

2011/01/N/NZ1/05269

Keywords:

antifungal compounds polyene macrolides derivatives selective toxicity

Descriptors:

  • NZ1_2: Biochemistry
  • NZ1_3: Biophysics
  • NZ1_7: Cell engineering

Panel:

NZ1 - Molecular biology, structural biology, biotechnology: molecular biology, structural biology, biotechnology

Host institution :

Politechnika Gdańska, Wydział Chemiczny

woj. pomorskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

Joanna Boros-Majewska 

Number of co-investigators in the project: 1

Call: PRELUDIUM 1 - announced on 2011-03-15

Amount awarded: 117 000 PLN

Project start date (Y-m-d): 2011-12-07

Project end date (Y-m-d): 2014-09-06

Project duration:: 33 months (the same as in the proposal)

Project status: Project settled

Information in the final report

  • Publication in academic press/journals (2)
  • Articles in post-conference publications (3)
  1. Novel Nystatin A 1 derivatives exhibiting low host cell toxicity and antifungal activity in an in vitro model of oral candidosis.
    Authors:
    Joanna Boros-Majewska, Natalia Salewska, Edward Borowski, Sławomir Milewski, Sladjana Malic, Xiao-Qing Wei, Anthony J. Hayes, Melanie J. Wilson, David W. Williams
    Academic press:
    Medical Microbiology and Immunology (rok: 2014, tom: 203, strony: 341-355), Wydawca: Springer Berlin Heidelberg
    Status:
    Published
    DOI:
    10.1007/s00430-014-0343-4 - link to the publication
  2. A novel in vitro assay for assessing efficacy and toxicity of antifungals using human leukemic cells infected with Candida albicans.
    Authors:
    Joanna Boros-Majewska, Łukasz Turczyk, Xiao‑Qing Wei, Sławomir Milewski, David W. Williams
    Academic press:
    Journal of Applied Microbiology (rok: 2015, ), Wydawca: Wiley-Blackwell
    Status:
    Submitted
    DOI:
    brak - link to the publication
  1. 3D in vitro epithelial tissue model – how to use to study of antifungal agents?
    Authors:
    Joanna Boros-Majewska, Natalia Salewska, Sladjana Malic, Xiao-Qing Wei, Anthony Hayes, David W. Williams, Sławomir Milewski
    Conference:
    48th Congress of the Polish Biochemical Society (rok: 2013, ), Wydawca: Polish Biochemical Society and the Committee of Biochemistry and Biophysics Polish Academy of Sciences
    Data:
    konferencja 2-5 September
    Status:
    Published
  2. An in vitro infection of human leukocytes with Candida albicans to study of host- pathogen interactions.
    Authors:
    Joanna Boros-Majewska, Jakub Karczewski, Sławomir Milewski
    Conference:
    BIO 2014 Congress; 1st Congress of the Polish Biochemistry, Cell Biology, Biophysics and Bioinformatics (rok: 2014, ), Wydawca: Polish Biochemical Society and the Committee of Biochemistry and Biophysics Polish Academy of Sciences
    Data:
    konferencja 9-12 September
    Status:
    Published
  3. Does the chemical modification of Nystatin A1 affect the drug's ability to overcome the multidrug resistance of fungi?
    Authors:
    Joanna Boros-Majewska, Natalia Salewska, Maria J. Milewska, Sławomir Milewski, Edward Borowski
    Conference:
    18th Congress of the International Society for Human and Animal Mycology (rok: 2012, ), Wydawca: Wiley-Blackwell
    Data:
    konferencja 11-15 June
    Status:
    Published

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