Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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A comparison of neuroprotective features of human mesenchymal stem cells (MSC) derived from adult (bon marrow) and neonatal (umbilical cord blood and Wharton Jelly) tissues

2011/01/B/NZ3/05401

Keywords:

neuroprotection cell therapy

Descriptors:

  • NZ3_8: Stem cell biology
  • NZ3_6: Cell neurobiology
  • NZ3_5: Molecular neurobiology

Panel:

NZ3 - Cellular and developmental biology: cell biology, developmental biology, ageing biology, neurobiology

Host institution :

Instytut Medycyny Doświadczalnej i Klinicznej im. Mirosława Mossakowskiego PAN

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Krystyna Domańska-Janik 

Number of co-investigators in the project: 9

Call: OPUS 1 - announced on 2011-03-15

Amount awarded: 619 100 PLN

Project start date (Y-m-d): 2011-12-08

Project end date (Y-m-d): 2015-12-07

Project duration:: 48 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. Aparat MagMax do izolacji RNA/DNA (79 000 PLN)
  2. Inkubator CO2-O2 f-my Biogenet i Komora Laminarna f-my ALAB.
  3. Aparat MiniMidi MACS do sortowania komórek (24 000 PLN)

Information in the final report

  • Publication in academic press/journals (8)
  1. Enhanced neuro-therapeutic potential of Wharton's Jelly derived MSC in comparison to bone marrow MSC culture
    Authors:
    Katarzyna Drela1, Wioletta Lech1, Anna Figiel-Dabrowska1, Marzena Zychowicz1, Michał Mikula 2, Anna Sarnowska1, Krystyna Domanska-Janik1
    Academic press:
    Cytotherapy (rok: 2016, tom: 8 (4), strony: 497-509), Wydawca: Published by Elsevier Inc.
    Status:
    Accepted for publication
    DOI:
    10.1016/j.jcyt.2016.01.006 - link to the publication
  2. Bioinżynieria niszy neuralnych komórek macierzystych
    Authors:
    Buzańska L, Zychowicz M, Sarnowska A, Domańska-Janik K
    Academic press:
    Postepy Biochemii (rok: 2013, tom: 59(2), strony: 175-186), Wydawca: PTBioch
    Status:
    Published
    DOI:
    brak - link to the publication
  3. 1.Encapsulation of mesenchymal stem cells by bioscaffolds protects cell survival and attenuates neuroinflammatory reaction in injured brain tissue after transplantation.
    Authors:
    Sarnowska A, Jablonska A, Jurga M, Dainiak M, Strojek L, Drela K, Wright K, Tripathi A, Kumar A, Jungvid H, Lukomska B, Forraz N, McGuckin C, Domanska-Janik K
    Academic press:
    Cell Transplantation (rok: 2013, tom: 22, strony: S67-82), Wydawca: Cognizant Communication Corporation
    Status:
    Published
    DOI:
    10.3727/096368913X672172 - link to the publication
  4. 2.Epigenetic and molecularsignature of human umbilical cord blood-derived neural stem cell (HUCB-NSC) neuronal differentiation.
    Authors:
    Habich A, Szablowska-Gadomska I, Zayat V, Buzanska L, Domańska-Janik K.
    Academic press:
    Acta Neurobiol Exp (Wars). (rok: 2013, tom: 73(1), strony: 143-56), Wydawca: PTBUN,Nencki
    Status:
    Published
    DOI:
    brak - link to the publication
  5. . Induction of endothelial phenotype from Warton Jelly-derived MSC and comparison of their vaso- and neuro-protective potential with primary WJ-MSC in CA1 hippocampal region ex vivo.
    Authors:
    Obtulowicz P, Lech W, Strojek L, Sarnowska A, Domanska-Janik K.
    Academic press:
    Cell Transplant. 2015 Dec 31. (rok: 2015, ), Wydawca: Cognizant Comm. Corp.USA
    Status:
    Accepted for publication
    DOI:
    [Epub - link to the publication
  6. Human mesenchymal stem cells in the treatment of neurological diseases
    Authors:
    Drela K, Siedlecka P, Sarnowska A, Domanska-Janik K
    Academic press:
    Acta NeurobiolExp (Wars) (rok: 2013, tom: 73(1), strony: 38-56), Wydawca: PTBUN, Nencki I
    Status:
    Published
    DOI:
    brak - link to the publication
  7. Low oxygen atmosphere facilitates proliferation and maintains undifferentiated state of umbilical cord mesenchymal stem cells in an hypoxia inducible factor-dependent manner.
    Authors:
    Drela K, Sarnowska A, Siedlecka P, Szablowska-Gadomska I, Wielgos M, Jurga M, Lukomska B, Domanska-Janik K.
    Academic press:
    Cytotherapy doi: 10.1016/j.jcyt.2014.02.009. Epub 2014 Apr 13. (rok: 2014, tom: Jul;16(7)2, strony: 881-9), Wydawca: Elsevier Inc.
    Status:
    Published
    DOI:
    10.1016/j.jcyt.2014.02.009. - link to the publication
  8. Terapia komórkowa w neurologii- obawy i nadzieje
    Authors:
    Sarnowska A., Habich A, Maksymaowicz W., Domanska-Janik K
    Academic press:
    Polski Przegląd Neurologiczny (rok: 2014, tom: 10 (1), strony: 45305), Wydawca: Via Medica
    Status:
    Published
    DOI:
    brak - link to the publication

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