Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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StAR protein trafficking of pro-atherogenic cholesterol hydroperoxides in macrophages

2011/01/B/NZ3/02167

Keywords:

atherogenesis cholesterol hydroperoxides macrophages

Descriptors:

  • NZ3_1: Cell biology
  • NZ3_3: Apoptosis
  • NZ3_7: Signal transduction

Panel:

NZ3 - Cellular and developmental biology: cell biology, developmental biology, ageing biology, neurobiology

Host institution :

UNIWERSYTET JAGIELLOŃSKI

woj. małopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr hab. Witold Korytowski 

Number of co-investigators in the project: 4

Call: OPUS 1 - announced on 2011-03-15

Amount awarded: 527 500 PLN

Project start date (Y-m-d): 2011-12-07

Project end date (Y-m-d): 2014-12-06

Project duration:: 36 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. Mikroskop laboratoryjny.
  2. Hood z laminarnym oplywem powietrza (60 000 PLN)
  3. Inkubator CO2/O2 (45 000 PLN)

Information in the final report

  • Publication in academic press/journals (3)
  • Articles in post-conference publications (1)
  • Book publications / chapters in book publications (2)
  1. Deleterious Cholesterol Hydroperoxide Trafficking in Steroidogenic Acute Regulatory (StAR) Protein-expressing MA-10 Leydig Cells IMPLICATIONS FOR OXIDATIVE STRESS-IMPAIRED STEROIDOGENESIS
    Authors:
    Korytowski, Witold); Pilat, Anna; Schmitt, JC ; Girotti, AW
    Academic press:
    Journal of Biological Chemistry (rok: 2013, tom: Volume: 288, strony: 11509-11519), Wydawca: ASBMB
    Status:
    Published
    DOI:
    10.1074/jbc.M113.452151 - link to the publication
  2. Impairment of Macrophage Reverse Cholesterol Transport by StAR-dependent Cholesterol Hydroperoxide Trafficking: Implications for Atherogenesis Under Oxidative Stress
    Authors:
    W. Korytowski, J.C. Schmitt, K. Wawak, P. Pabisz, D. Sahoo, A. Chadwick, A.W. Girotti
    Academic press:
    Arteriosclerosis, Thrombosis, and Vascular Biology (rok: 2015, tom: 35, strony: 2104-2113), Wydawca: Lippincott Williams & Wilkins, American Heart Association
    Status:
    Published
    DOI:
    10.1161/ATVBAH.115.306210 - link to the publication
  3. Macrophage Mitochondrial Damage from StAR Transport of 7-Hydroperoxycholesterol: Implications for oxidative stress-impaired reverse cholesterol transport
    Authors:
    Witold Korytowski, Katarzyna Wawak, Pawel Pabisz, Jared C. Schmitt, Albert W. Girotti
    Academic press:
    FEBS Letters (rok: 2014, tom: 588, strony: 65-70), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.051 - link to the publication
  1. Impairment of Macrophage Reverse Cholesterol Transport by StAR-Dependent Cholesterol Hydroperoxide Trafficking: Implications for Atherogenesis Under Oxidative Stress, , invited talk
    Authors:
    Korytowski W, Schmitt J, Wawak K, Pabisz P, Girotti A,
    Conference:
    21st Ann Meet SFRBM, Seattle, WA (rok: 2014, ), Wydawca: Free Rad. Biol. Med. Vol.76, 2014, p. S48, Elsevier
    Data:
    konferencja Nov 19-23, 2014
    Status:
    Published
    DOI:
    link to the publication
  1. GENERATION AND REACTIVITY OF LIPID HYDROPEROXIDES
    Authors:
    AW Girotti and W. Korytowski
    Book:
    The chemistry of peroxides (rok: 2014, tom: Vol 3, strony: 747-769), Wydawca: JOHN WILEY and SONS; Liebman & Greer
    Status:
    Published
  2. Reactions of Singlet Oxygen with Membrane Lipids: Lipid Hydroperoxide Generation, Translocation, Reductive Turnover, and Signaling Activity
    Authors:
    Albert W. Girotti and Witold Korytowski
    Book:
    Singlet Oxygen: Applications in Biosciences and Nanosciences (rok: 2015, tom: x, strony: xxx), Wydawca: Royal Society of Chemistry Publisher, England
    Status:
    Accepted for publication

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