Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Enantioselective and diastereoselective Petasis reaction: new approach, new conditions and catalysts. Application of the products in the synthesis of protoberberine alkaloids.

2011/01/D/ST5/06627

Keywords:

Petasis-Mannich reaction protoberberine alkaloids stereochemistry organoboronic acids

Descriptors:

  • ST5_18:
  • ST5_23:

Panel:

ST5 - Materials: materials synthesis, structure-properties relations, advanced and functional materials with designed properties, (macro)molecular architecture, material engineering

Host institution :

Uniwersytet im. Adama Mickiewicza, Wydział Chemii

woj. wielkopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Agnieszka Grajewska 

Number of co-investigators in the project: 4

Call: SONATA 1 - announced on 2011-03-15

Amount awarded: 440 000 PLN

Project start date (Y-m-d): 2011-12-13

Project end date (Y-m-d): 2016-10-12

Project duration:: 58 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. Pompa próżniowa.
  2. Mieszadło magnetyczne z czujnikiem temperatury (3 szt.) (5 800 PLN)
  3. Kolumna chiralna do chromatografu.
  4. Suszarka laboratoryjna (5 000 PLN)
  5. Wysokosprawny chromatograf cieczowy wraz z chiralną kolumną, komputerem i odpowiednim oprogramowaniem (133 000 PLN)
  6. Kontroler próżni (4 000 PLN)
  7. Waga analityczna (5 000 PLN)

Information in the final report

  • Publication in academic press/journals (5)
  1. Synthesis of Calycotomine and N-Methylcalycotomine Using a Petasis Reaction — Pomeranz-Fritsch-Bobbitt Cyclization Sequence
    Authors:
    Maria Chrzanowska, Agnieszka Grajewska, Maria D. Rozwadowska
    Academic press:
    Heterocycles (rok: 2012, tom: 86, strony: 1119-1127), Wydawca: The Japan Institute of Heterocyclic Chemistry
    Status:
    Published
    DOI:
    10.3987/COM-12-S(N)59 - link to the publication
  2. SYNTHESIS AND CRYSTAL STRUCTURE OF (4S)-4-BENZYL-3-(4,5-DIMETHOXY-2-METHYLBENZOYL)- 2,2-DIMETHYL-1,3-OXAZOLIDINE
    Authors:
    Maria Chrzanowska, Zofia Meissner, Joanna M. Chrzanowska, Andrzej K. Gzellab
    Academic press:
    Heterocycles (rok: 2015, tom: 90, strony: 730-739), Wydawca: The Japan Institute of Heterocyclic Chemistry
    Status:
    Published
    DOI:
    10.3987/COM-14-S(K)54 - link to the publication
  3. Synthesis of (+)-6,7-Dimethoxy-1,2,3,4-tetrahydroisoquinoline-1-carboxylic Acid, a Diastereoselective Approach
    Authors:
    Ilona Bułyszko, Maria Chrzanowska, Agnieszka Grajewska, Maria D. Rozwadowska
    Academic press:
    European Journal of Organic Chemistry (rok: 2015, tom: -, strony: 383-388), Wydawca: Wiley-VCH Verlag GmbH & Co
    Status:
    Published
    DOI:
    10.1002/ejoc.201403218 - link to the publication
  4. Asymmetric Synthesis of Isoquinoline Alkaloids: 2004−2015
    Authors:
    Maria Chrzanowska, Agnieszka Grajewska, Maria D. Rozwadowska
    Academic press:
    Chemical Reviews (rok: 2016, tom: 116, strony: 12369−12465), Wydawca: American Chemical Society
    Status:
    Published
    DOI:
    10.1021/acs.chemrev.6b00315 - link to the publication
  5. Enantiospecific synthesis of (S)-(-)-8-oxoxylopinine
    Authors:
    Zofia Meissner, Maria Chrzanowska
    Academic press:
    Tetrahedron: Asymmetry (rok: 2015, tom: 26, strony: 225-229), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.tetasy.2015.01.002 - link to the publication

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