Projects funded by the NCN
Genome abberations, p53 status and nitrosative-oxidative stress manifestation during establishment of methotrexate-induced premature senescence in human colon cancer cells
2011/01/B/NZ4/00371
Keywords:
methotrexate colon cancer therapy-induced senescence (premature senescence) p53 nitrosative-oxidative stress DNA damage Comparative Genomic Hybridization (CGH)
Descriptors:
- NZ4_11: Metabolism
- NZ4_17:
- NZ4_18:
Panel:
NZ4 - Biology of tissues, organs and organisms: morphology and functions of animal's and human's systems, organs and organisms, experimental medicine, basics of neurology
Host institution :
INSTYTUT BIOLOGII DOŚWIADCZALNEJ PAN IM.M.NENCKIEGO
woj. mazowieckie
Principal investigator (from the host institution):
Number of co-investigators in the project: 3
Call: OPUS 1 - announced on 2011-03-15
Amount awarded: 300 000 PLN
Project start date (Y-m-d): 2011-12-15
Project end date (Y-m-d): 2015-12-14
Project duration:: 48 months (the same as in the proposal)
Project status: Project settled
Equipment purchased [PL]
- Roczna licencja na program Agilent Genomic Workbench (31 393 PLN)
Information in the final report
- Publication in academic press/journals (2)
- Articles in post-conference publications (1)
- E2F site in the essential promoter region does not confer S phase-specific transcription of the ABCC10 gene in human prostate cancer cellsAuthors:Magdalena Dabrowska, Francis M. SirotnakAcademic press:Acta Biochimica Polonica (rok: 2017, tom: 64, strony: 371-374), Wydawca: Polish Biochemical SocietyStatus:PublishedDOI:10.18388/abp.2017_1521 - link to the publication
- Oxidative stress and inhibition of nitric oxide generation underlie methotrexate-induced senescence in human colon cancer cellsAuthors:Magdalena Dabrowska, Lukasz Uram, Zbigniew Zielinski, Wojciech Rode, Ewa SikoraAcademic press:Mechanisms of Ageing and Development (rok: 2018, tom: 170, strony: 22-29), Wydawca: ElsevierStatus:PublishedDOI:10.1016/j.mad.2017.07.006 - link to the publication
- Dihydrofolate reductase protein stabilization by methotrexate is associated with up-regulation of inducible nitric oxide synthase (iNOS) expression in human colon cancer cellsAuthors:Magdalena Dabrowska, Zbigniew Zielinski, Kamila Litewiak, Adam Jagielski, Wojciech RodeConference:9th International Conference of Anticancer Resaearch (rok: 2014, ), Wydawca: International Institute of Anticancer Research (Dr. John G. Delinasios)Data:konferencja 6-10 październikaStatus:Published