Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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DNA damage-induced signalling pathways leading to senescence of cancer cells

2011/01/M/NZ1/01597

Keywords:

cellular senescence DNA damage NF-kappaB

Descriptors:

  • NZ1_1: Molecular biology
  • NZ1_7: Cell engineering

Panel:

NZ1 - Molecular biology, structural biology, biotechnology: molecular biology, structural biology, biotechnology

Host institution :

Instytut Biologii Doświadczalnej im. M. Nenckiego PAN

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Ewa Sikora 

Number of co-investigators in the project: 7

Call: HARMONIA 1 - announced on 2011-03-15

Amount awarded: 724 000 PLN

Project start date (Y-m-d): 2011-12-06

Project end date (Y-m-d): 2014-12-05

Project duration:: 36 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. Mikroskop odwrócony MBI100T firmy Mikrolab z kontrastem fazowym.
  2. Przestrajany ciekłokrystaliczny filtr RGB do kamery Retiga 1300.
  3. wirówka z chłodzeniem (24 000 PLN)

Information in the final report

  • Publication in academic press/journals (4)
  1. Curcumin induces permanent growth arrest of human colon cancer cells: Link between senescence and autophagy
    Authors:
    Mosieniak G, Adamowicz M, Alster O, Jaskowiak H, Szczepankiewicz AA, Wilczynski GM, Ciechomska IA, Sikora E.
    Academic press:
    Mechanism of Aging and Development (rok: 2012, tom: 133(6), strony: 444-455), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.mad.2012.05.004 - link to the publication
  2. The Role of Nibrin in Doxorubicin-Induced Apoptosis and Cell Senescence in Nijmegen Breakage Syndrome Patients Lymphocytes
    Authors:
    Olga Alster, Anna Bielak-Zmijewska, Grazyna Mosieniak, Maria Moreno-Villanueva, Wioleta Dudka- Ruszkowska, Aleksandra Wojtala, Monika Kusio-Kobiałka, Zbigniew Korwek, Alexander Burkle, Katarzyna Piwocka, Jan K. Siwicki, Ewa Sikora
    Academic press:
    PlosOne (rok: 2014, tom: 9, strony: e104964), Wydawca: Public Library of Science
    Status:
    Published
    DOI:
    10.1371/journal.pone.0104964. - link to the publication
  3. Polyploidy Formation in Doxorubicin-Treated Cancer Cells Can Favour Escape From Senescence
    Authors:
    Mosieniak G, Sliwinska MA, Alster O, Strzeszewska A, Sunderland P, Piechota M, Was H, Sikora E
    Academic press:
    Neoplasia (rok: 2015, tom: 17, strony: 882-893), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.neo.2015.11.008 - link to the publication
  4. Morphological and functional characteristic of senescent cancer cells
    Authors:
    Ewa Sikora, Grażyna Mosieniak, Malgorzata Alicja Sliwinska
    Academic press:
    Current Drugs Targets (rok: 2016, tom: 17, strony: 377-387), Wydawca: Bentham Science
    Status:
    Published
    DOI:
    brak - link to the publication

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