Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Peptidyl arginine deiminase, a novel virulence factor of Porphyromonas gingivalis

2011/01/B/NZ6/00268

Keywords:

Porphyromonas gingivalis periodontitis citrullination bacterial enzymes pepidyl-deiminases autoimmunology diseases

Descriptors:

  • NZ1_2: Biochemistry
  • NZ1_1: Molecular biology
  • NZ6_4: Bacteriology

Panel:

NZ6 - Human and animal immunology and infection: immunity, immune disorders, immunotherapy, infectious and invasive diseases, microbiology, transplantology, allergology

Host institution :

Uniwersytet Jagielloński, Wydział Biochemii, Biofizyki i Biotechnologii

woj. małopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Jan Potempa 

Number of co-investigators in the project: 3

Call: OPUS 1 - announced on 2011-03-15

Amount awarded: 600 000 PLN

Project start date (Y-m-d): 2011-12-12

Project end date (Y-m-d): 2014-12-11

Project duration:: 36 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. Drukarka HP LJM.
  2. Liofilizator Labconco (150 000 PLN)
  3. Laptop W7HP DRL, Pendrive 4GB.
  4. Laptop BW7HP DRL, Dysk USB 4G, mysz laserowa.

Information in the final report

  • Publication in academic press/journals (23)
  1. Citrullination alters immunomodulatory function of LL-37 essential for prevention of endotoxin-induced sepsis.
    Authors:
    Koziel J, Bryzek D, Sroka A, Maresz K, Glowczyk I, Bielecka E, Kantyka T, Pyrć K, Svoboda P, Pohl J, Potempa J.
    Academic press:
    JOURNAL OF IMMUNOLOGY (rok: 2014, tom: 192, strony: 6363-5372), Wydawca: American Association of Immunologists
    Status:
    Published
    DOI:
    10.4049/jimmunol.1303062 - link to the publication
  2. Evidence of mutualism between two periodontal pathogens: co-operative haem acquisition by the HmuY haemophore of Porphyromonas gingivalis and the cysteine protease interpain A (InpA) of Prevotella intermedia.
    Authors:
    Byrne DP, Potempa J, Olczak T, Smalley JW
    Academic press:
    Molecular Oral Microbiology (rok: 2013, tom: 28, strony: 219-229), Wydawca: Blackwell Publishing Ltd
    Status:
    Published
    DOI:
    10.1111/omi.12018 - link to the publication
  3. Gingipain aminopeptidase activities in Porphyromonas gingivalis
    Authors:
    Veillard, Florian; Potempa, Barbara; Poreba, Marcin; Drag, Marcin; Potempa, Jan
    Academic press:
    BIOLOGICAL CHEMISTRY (rok: 2012, tom: 393, strony: 1471-1476), Wydawca: WALTER DE GRUYTER & CO
    Status:
    Published
    DOI:
    10.1515/hsz-2012-0222 - link to the publication
  4. Glutaminyl Cyclases as Novel Targets for the Treatment of Septic Arthritis
    Authors:
    305.Hellvard, A., Maresz, K., Schilling, S., Graubner, S., Heiser, U., Cynis, H., Demuth, H.U., Jonsson, R., Potempa, J., and Mydel, P.
    Academic press:
    JOURNAL OF INFECTIOUS DISEASES Volume: Issue: 5 Pages: DOI: (rok: 2013, tom: 207, strony: 768-777), Wydawca: OXFORD UNIV PRESS INC
    Status:
    Published
    DOI:
    10.1093/infdis/jis729 - link to the publication
  5. Inactivation of Epidermal Growth Factor by Porphyromonas gingivalis as a Potential Mechanism for Periodontal Tissue Damage
    Authors:
    308.Pyrc, K., Milewska, A., Kantyka, T., Sroka, S., Maresz, K., Koziel, J., Enghild, J.J., Knudsen, A.D., and Potempa, J.
    Academic press:
    INFECTION AND IMMUNITY (rok: 2013, tom: 81, strony: 55-64), Wydawca: AMER SOC MICROBIOLOGY
    Status:
    Published
    DOI:
    10.1128/IAI.00830-12 - link to the publication
  6. Lack of cathelicidin processing in Papillon-Lefèvre syndrome patients reveals essential role of LL-37 in periodontal homeostasis.
    Authors:
    Eick S, Puklo M, Adamowicz K, Kantyka T, Hiemstra P, Stennicke H, Guentsch A, Schacher B, Eickholz P, Potempa J.
    Academic press:
    Orphanet Journal of Rare Diseases (rok: 2014, tom: 9, strony: 148), Wydawca: BioMedCentral
    Status:
    Published
    DOI:
    10.1186/s13023-014-0148-y - link to the publication
  7. Porphyromonas gingivalis Gingipains Selectively Reduce CD14 Expression, Leading to Macrophage Hyporesponsiveness to Bacterial Infection.
    Authors:
    Wilensky A, Tzach-Nahman R, Potempa J, Shapira L, Nussbaum G.
    Academic press:
    JOURNAL OF INNATE IMMUNITY (rok: 2015, tom: 7, strony: xxx-xxx), Wydawca: KARGER
    Status:
    Accepted for publication
    DOI:
    10.1159/000365970 - link to the publication
  8. Staphylococcal proteases aid in evasion of the human complement system
    Authors:
    Jusko M, Potempa J, Kantyka T, Bielecka E, Miller HK, Kalinska M, Dubin G, Garred P, Shaw LN, Blom AM
    Academic press:
    Journal of Innate Immunity (rok: 2014, tom: 6, strony: 31-46), Wydawca: KRAGER
    Status:
    Published
    DOI:
    10.1159/000351458 - link to the publication
  9. Protease-dependent mechanisms of complement evasion by bacterial pathogens
    Authors:
    Potempa, Michal; Potempa, Jan
    Academic press:
    BIOLOGICAL CHEMISTRY (rok: 2012, tom: 393, strony: 873-888), Wydawca: WALTER DE GRUYTER & CO
    Status:
    Published
    DOI:
    10.1515/hsz-2012-0174 - link to the publication
  10. A metalloproteinase karilysin present in the majority of Tannerella forsythia isolates inhibits all pathways of the complement system.
    Authors:
    Jusko M, Potempa J, Karim AY, Ksiazek M, Riesbeck K, Garred P, Eick S, Blom AM.
    Academic press:
    Journal of Immunology (rok: 2012, tom: 188, strony: 2338-2349), Wydawca: AMER ASSOC IMMUNOLOGISTS
    Status:
    Published
    DOI:
    10.4049/jimmunol.1101240 - link to the publication
  11. Benzamidine derivatives inhibit the virulence of Porphyromonas gingivalis
    Authors:
    Fröhlich E, Kantyka T, Plaza K, Schmidt KH, Pfister W, Potempa J, Eick S
    Academic press:
    Molecular Oral Microbiology (rok: 2013, tom: 28, strony: 192-203), Wydawca: John Wiley & Sons A/S
    Status:
    Published
    DOI:
    10.1111/omi.12015 - link to the publication
  12. Disruption of gingipain oligomerization into non-covalent cell-surface attached complexes
    Authors:
    Sztukowska, M; Veillard, F; Potempa, B; Bogyo, M; Enghild, JJ; Thogersen, IB; Nguyen, KA; Potempa, J
    Academic press:
    BIOLOGICAL CHEMISTRY (rok: 2012, tom: 393, strony: 971-977), Wydawca: WALTER DE GRUYTER & CO
    Status:
    Published
    DOI:
    10.1515/hsz-2012-0175 - link to the publication
  13. Peptidylarginine deiminase from Porphyromonas gingivalis contributes to infection of gingival fibroblasts and induction of prostaglandin E2 -signaling pathway.
    Authors:
    Gawron K, Bereta G, Nowakowska Z, Lazarz-Bartyzel K, Lazarz M, Szmigielski B, Mizgalska D, Buda A, Koziel J, Oruba Z, Chomyszyn-Gajewska M, Potempa J.
    Academic press:
    Molecular Oral Microbiology (rok: 2014, tom: 29, strony: 321-332), Wydawca: John Wiley & Sons Ltd.
    Status:
    Published
    DOI:
    10.1111/omi.12081 - link to the publication
  14. The link between periodontal disease and rheumatoid arthritis: an updated review.
    Authors:
    Koziel J, Mydel P, Potempa J.
    Academic press:
    Current Rheumatology Reports (rok: 2014, tom: 16, strony: 408), Wydawca: Springer Link
    Status:
    Published
    DOI:
    10.1007/s11926-014-0408-9 - link to the publication
  15. A Phage Display Selected 7-mer Peptide Inhibitor of the Tannerella forsythia Metalloprotease-Like Enzyme Karilysin Can Be Truncated to Ser-Trp-Phe-Pro
    Authors:
    Skottrup, Peter Durand; Sorensen, Grete; Ksiazek, Miroslaw; Potempa, Jan; Riise, Erik
    Academic press:
    PLoS One (rok: 2012, tom: 7, strony: e48537), Wydawca: PUBLIC LIBRARY SCIENCE
    Status:
    Published
    DOI:
    10.1371/journal.pone.0048537 - link to the publication
  16. Carbamylation of immunoglobulin abrogates activation of the classical complement pathway.
    Authors:
    Koro C, Bielecka E, Dahl-Knudsen A, Enghild JJ, Scavenius C, Brun JG, Binder V, Hellvard A, Bergum B, Jonsson R, Potempa J, Blom AM, Mydel P.
    Academic press:
    European Journal of Immunology (rok: 2014, tom: 44, strony: 3403-3412), Wydawca: WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
    Status:
    Published
    DOI:
    0.1002/eji.201444869 - link to the publication
  17. Citrullination and proteolytic processing of chemokines by Porphyromonas gingivalis.
    Authors:
    Moelants EA, Loozen G, Mortier A, Martens E, Opdenakker G, Mizgalska D, Szmigielski B, Potempa J, Van Damme J, Teughels W, Proost P.
    Academic press:
    INFECTION AND IMMUNITY (rok: 2014, tom: 82, strony: 2511-2519), Wydawca: American Society for Microbiology
    Status:
    Published
    DOI:
    10.1128/IAI.01624-14 - link to the publication
  18. Cleavage of extracellular matrix in periodontitis: gingipains differentially affect cell adhesion activities of fibronectin and tenascin-C.
    Authors:
    Ruggiero S, Cosgarea R, Potempa J, Potempa B, Eick S, Chiquet M
    Academic press:
    BBA Mol. Basis Dis. (rok: 2013, tom: 1832, strony: 517-526), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.bbadis.2013.01.003 - link to the publication
  19. Peptidyl arginine deiminase from Porphyromonas gingivalis abolishes anaphylatoxin C5a activity
    Authors:
    Bielecka E, Scavenius C, Kantyka T, Jusko M, Mizgalska D, Szmigielski B, Potempa B, Enghild JJ, Prossnitz ER, Blom AM, Potempa J.
    Academic press:
    Journal of Biological Chemistry (rok: 2014, tom: 289, strony: 32481-32487), Wydawca: The American Society for Biochemistry and Molecular Biology, Inc.
    Status:
    Published
    DOI:
    10.1074/jbc.C114.617142 - link to the publication
  20. Porphyromonas gingivalis facilitates the development and progression of destructive arthritis through its unique bacterial peptidylarginine deiminase (PAD)
    Authors:
    Maresz KJ, Hellvard A, Sroka A, Adamowicz K, Bielecka E, Koziel J, Gawron K, Mizgalska D, Marcinska KA, Benedyk M, Pyrc K, Quirke AM, Jonsson R, Alzabin S, Venables PJ, Nguyen KA, Mydel P, Potempa J
    Academic press:
    PLoS Pathogens (rok: 2013, tom: 9, strony: e1003627), Wydawca: www.plospathogens.org
    Status:
    Published
    DOI:
    10.1371/journal.ppat.1003627 - link to the publication
  21. Porphyromonas gingivalis virulence factor gingipain RgpB shows a unique zymogenic mechanism for cysteine peptidases.
    Authors:
    de Diego I, Veillard FT, Guevara T, Potempa B, Sztukowska M, Potempa J, Gomis-Rüth FX
    Academic press:
    Journal of Biological Chemistry (rok: 2013, tom: 288, strony: 14287-14296), Wydawca: ASBMB
    Status:
    Published
    DOI:
    10.1074/jbc.M112.444927 - link to the publication
  22. Protease-armed bacteria in the skin
    Authors:
    Koziel, Joanna; Potempa, Jan
    Academic press:
    CELL AND TISSUE RESEARCH (rok: 2013, tom: 351, strony: 325-337), Wydawca: SPRINGER
    Status:
    Published
    DOI:
    10.1007/s00441-012-1355-2 - link to the publication
  23. The Staphylococcus aureus leucine aminopeptidase is localized to the bacterial cytosol and demonstrates a broad substrate range that extends beyond leucine
    Authors:
    Carroll RK, Veillard F, Gagne DT, Lindenmuth JM, Poreba M, Drag M, Potempa J, Shaw LN
    Academic press:
    Biological Chemistry (rok: 2013, tom: 394, strony: 791-803), Wydawca: De Gruyter
    Status:
    Published
    DOI:
    10.1515/hsz-2012-0308 - link to the publication

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