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Peptidyl arginine deiminase, a novel virulence factor of Porphyromonas gingivalis

2011/01/B/NZ6/00268

Keywords

Descriptors

  • NZ1_2: Biochemia
  • NZ1_1: Biologia molekularna
  • NZ6_4: Bakteriologia

Panel

NZ6 – Human and animal immunology and infection: immunity, immune disorders, immunotherapy, infectious and invasive diseases, microbiology, transplantology, allergology

Host institution

Uniwersytet Jagielloński, Wydział Biochemii, Biofizyki i Biotechnologii

Voivodeship: małopolskie

Other projects carried out by the institution »

Principal investigator (from the host institution)

prof. Jan Stanislaw Potempa

Number of co-investigators in the project: 3

Call

OPUS 1 – announced on 2011-03-15

Amount awarded
600 000 PLN
Project start date
2011-12-12
Project end date
2014-12-11
Project duration
36 months (the same as in the proposal)
Project status
Project settled

Equipment purchased [PL]

  1. Laptop W7HP DRL, Pendrive 4GB.
  2. Drukarka HP LJM.
  3. Laptop BW7HP DRL, Dysk USB 4G, mysz laserowa.
  4. Liofilizator Labconco. Cost: 150 000 PLN

Information in the final report

Publication in academic press/journals (23)

  1. Inactivation of Epidermal Growth Factor by Porphyromonas gingivalis as a Potential Mechanism for Periodontal Tissue Damage

    Authors:
    308.Pyrc, K., Milewska, A., Kantyka, T., Sroka, S., Maresz, K., Koziel, J., Enghild, J.J., Knudsen, A.D., and Potempa, J.
    Academic press:
    INFECTION AND IMMUNITY (year: 2013, volume: 81, pages: 55-64), Publisher: AMER SOC MICROBIOLOGY
    Status:
    Published
    DOI:
    10.1128/IAI.00830-12 – link to the publication

  2. Cleavage of extracellular matrix in periodontitis: gingipains differentially affect cell adhesion activities of fibronectin and tenascin-C.

    Authors:
    Ruggiero S, Cosgarea R, Potempa J, Potempa B, Eick S, Chiquet M
    Academic press:
    BBA Mol. Basis Dis. (year: 2013, volume: 1832, pages: 517-526), Publisher: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.bbadis.2013.01.003 – link to the publication

  3. Glutaminyl Cyclases as Novel Targets for the Treatment of Septic Arthritis

    Authors:
    305.Hellvard, A., Maresz, K., Schilling, S., Graubner, S., Heiser, U., Cynis, H., Demuth, H.U., Jonsson, R., Potempa, J., and Mydel, P.
    Academic press:
    JOURNAL OF INFECTIOUS DISEASES Volume: Issue: 5 Pages: DOI: (year: 2013, volume: 207, pages: 768-777), Publisher: OXFORD UNIV PRESS INC
    Status:
    Published
    DOI:
    10.1093/infdis/jis729 – link to the publication

  4. The Staphylococcus aureus leucine aminopeptidase is localized to the bacterial cytosol and demonstrates a broad substrate range that extends beyond leucine

    Authors:
    Carroll RK, Veillard F, Gagne DT, Lindenmuth JM, Poreba M, Drag M, Potempa J, Shaw LN
    Academic press:
    Biological Chemistry (year: 2013, volume: 394, pages: 791-803), Publisher: De Gruyter
    Status:
    Published
    DOI:
    10.1515/hsz-2012-0308 – link to the publication

  5. A Phage Display Selected 7-mer Peptide Inhibitor of the Tannerella forsythia Metalloprotease-Like Enzyme Karilysin Can Be Truncated to Ser-Trp-Phe-Pro

    Authors:
    Skottrup, Peter Durand; Sorensen, Grete; Ksiazek, Miroslaw; Potempa, Jan; Riise, Erik
    Academic press:
    PLoS One (year: 2012, volume: 7, pages: e48537), Publisher: PUBLIC LIBRARY SCIENCE
    Status:
    Published
    DOI:
    10.1371/journal.pone.0048537 – link to the publication

  6. Benzamidine derivatives inhibit the virulence of Porphyromonas gingivalis

    Authors:
    Fröhlich E, Kantyka T, Plaza K, Schmidt KH, Pfister W, Potempa J, Eick S
    Academic press:
    Molecular Oral Microbiology (year: 2013, volume: 28, pages: 192-203), Publisher: John Wiley & Sons A/S
    Status:
    Published
    DOI:
    10.1111/omi.12015 – link to the publication

  7. Evidence of mutualism between two periodontal pathogens: co-operative haem acquisition by the HmuY haemophore of Porphyromonas gingivalis and the cysteine protease interpain A (InpA) of Prevotella intermedia.

    Authors:
    Byrne DP, Potempa J, Olczak T, Smalley JW
    Academic press:
    Molecular Oral Microbiology (year: 2013, volume: 28, pages: 219-229), Publisher: Blackwell Publishing Ltd
    Status:
    Published
    DOI:
    10.1111/omi.12018 – link to the publication

  8. Citrullination alters immunomodulatory function of LL-37 essential for prevention of endotoxin-induced sepsis.

    Authors:
    Koziel J, Bryzek D, Sroka A, Maresz K, Glowczyk I, Bielecka E, Kantyka T, Pyrć K, Svoboda P, Pohl J, Potempa J.
    Academic press:
    JOURNAL OF IMMUNOLOGY (year: 2014, volume: 192, pages: 6363-5372), Publisher: American Association of Immunologists
    Status:
    Published
    DOI:
    10.4049/jimmunol.1303062 – link to the publication

  9. Citrullination and proteolytic processing of chemokines by Porphyromonas gingivalis.

    Authors:
    Moelants EA, Loozen G, Mortier A, Martens E, Opdenakker G, Mizgalska D, Szmigielski B, Potempa J, Van Damme J, Teughels W, Proost P.
    Academic press:
    INFECTION AND IMMUNITY (year: 2014, volume: 82, pages: 2511-2519), Publisher: American Society for Microbiology
    Status:
    Published
    DOI:
    10.1128/IAI.01624-14 – link to the publication

  10. Disruption of gingipain oligomerization into non-covalent cell-surface attached complexes

    Authors:
    Sztukowska, M; Veillard, F; Potempa, B; Bogyo, M; Enghild, JJ; Thogersen, IB; Nguyen, KA; Potempa, J
    Academic press:
    BIOLOGICAL CHEMISTRY (year: 2012, volume: 393, pages: 971-977), Publisher: WALTER DE GRUYTER & CO
    Status:
    Published
    DOI:
    10.1515/hsz-2012-0175 – link to the publication

  11. Protease-armed bacteria in the skin

    Authors:
    Koziel, Joanna; Potempa, Jan
    Academic press:
    CELL AND TISSUE RESEARCH (year: 2013, volume: 351, pages: 325-337), Publisher: SPRINGER
    Status:
    Published
    DOI:
    10.1007/s00441-012-1355-2 – link to the publication

  12. A metalloproteinase karilysin present in the majority of Tannerella forsythia isolates inhibits all pathways of the complement system.

    Authors:
    Jusko M, Potempa J, Karim AY, Ksiazek M, Riesbeck K, Garred P, Eick S, Blom AM.
    Academic press:
    Journal of Immunology (year: 2012, volume: 188, pages: 2338-2349), Publisher: AMER ASSOC IMMUNOLOGISTS
    Status:
    Published
    DOI:
    10.4049/jimmunol.1101240 – link to the publication

  13. Staphylococcal proteases aid in evasion of the human complement system

    Authors:
    Jusko M, Potempa J, Kantyka T, Bielecka E, Miller HK, Kalinska M, Dubin G, Garred P, Shaw LN, Blom AM
    Academic press:
    Journal of Innate Immunity (year: 2014, volume: 6, pages: 31-46), Publisher: KRAGER
    Status:
    Published
    DOI:
    10.1159/000351458 – link to the publication

  14. Gingipain aminopeptidase activities in Porphyromonas gingivalis

    Authors:
    Veillard, Florian; Potempa, Barbara; Poreba, Marcin; Drag, Marcin; Potempa, Jan
    Academic press:
    BIOLOGICAL CHEMISTRY (year: 2012, volume: 393, pages: 1471-1476), Publisher: WALTER DE GRUYTER & CO
    Status:
    Published
    DOI:
    10.1515/hsz-2012-0222 – link to the publication

  15. Protease-dependent mechanisms of complement evasion by bacterial pathogens

    Authors:
    Potempa, Michal; Potempa, Jan
    Academic press:
    BIOLOGICAL CHEMISTRY (year: 2012, volume: 393, pages: 873-888), Publisher: WALTER DE GRUYTER & CO
    Status:
    Published
    DOI:
    10.1515/hsz-2012-0174 – link to the publication

  16. Porphyromonas gingivalis facilitates the development and progression of destructive arthritis through its unique bacterial peptidylarginine deiminase (PAD)

    Authors:
    Maresz KJ, Hellvard A, Sroka A, Adamowicz K, Bielecka E, Koziel J, Gawron K, Mizgalska D, Marcinska KA, Benedyk M, Pyrc K, Quirke AM, Jonsson R, Alzabin S, Venables PJ, Nguyen KA, Mydel P, Potempa J
    Academic press:
    PLoS Pathogens (year: 2013, volume: 9, pages: e1003627), Publisher: www.plospathogens.org
    Status:
    Published
    DOI:
    10.1371/journal.ppat.1003627 – link to the publication

  17. Peptidyl arginine deiminase from Porphyromonas gingivalis abolishes anaphylatoxin C5a activity

    Authors:
    Bielecka E, Scavenius C, Kantyka T, Jusko M, Mizgalska D, Szmigielski B, Potempa B, Enghild JJ, Prossnitz ER, Blom AM, Potempa J.
    Academic press:
    Journal of Biological Chemistry (year: 2014, volume: 289, pages: 32481-32487), Publisher: The American Society for Biochemistry and Molecular Biology, Inc.
    Status:
    Published
    DOI:
    10.1074/jbc.C114.617142 – link to the publication

  18. The link between periodontal disease and rheumatoid arthritis: an updated review.

    Authors:
    Koziel J, Mydel P, Potempa J.
    Academic press:
    Current Rheumatology Reports (year: 2014, volume: 16, pages: 408), Publisher: Springer Link
    Status:
    Published
    DOI:
    10.1007/s11926-014-0408-9 – link to the publication

  19. Porphyromonas gingivalis virulence factor gingipain RgpB shows a unique zymogenic mechanism for cysteine peptidases.

    Authors:
    de Diego I, Veillard FT, Guevara T, Potempa B, Sztukowska M, Potempa J, Gomis-Rüth FX
    Academic press:
    Journal of Biological Chemistry (year: 2013, volume: 288, pages: 14287-14296), Publisher: ASBMB
    Status:
    Published
    DOI:
    10.1074/jbc.M112.444927 – link to the publication

  20. Carbamylation of immunoglobulin abrogates activation of the classical complement pathway.

    Authors:
    Koro C, Bielecka E, Dahl-Knudsen A, Enghild JJ, Scavenius C, Brun JG, Binder V, Hellvard A, Bergum B, Jonsson R, Potempa J, Blom AM, Mydel P.
    Academic press:
    European Journal of Immunology (year: 2014, volume: 44, pages: 3403-3412), Publisher: WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
    Status:
    Published

  21. Lack of cathelicidin processing in Papillon-Lefèvre syndrome patients reveals essential role of LL-37 in periodontal homeostasis.

    Authors:
    Eick S, Puklo M, Adamowicz K, Kantyka T, Hiemstra P, Stennicke H, Guentsch A, Schacher B, Eickholz P, Potempa J.
    Academic press:
    Orphanet Journal of Rare Diseases (year: 2014, volume: 9, pages: 148), Publisher: BioMedCentral
    Status:
    Published
    DOI:
    10.1186/s13023-014-0148-y – link to the publication

  22. Peptidylarginine deiminase from Porphyromonas gingivalis contributes to infection of gingival fibroblasts and induction of prostaglandin E2 -signaling pathway.

    Authors:
    Gawron K, Bereta G, Nowakowska Z, Lazarz-Bartyzel K, Lazarz M, Szmigielski B, Mizgalska D, Buda A, Koziel J, Oruba Z, Chomyszyn-Gajewska M, Potempa J.
    Academic press:
    Molecular Oral Microbiology (year: 2014, volume: 29, pages: 321-332), Publisher: John Wiley & Sons Ltd.
    Status:
    Published
    DOI:
    10.1111/omi.12081 – link to the publication

  23. Porphyromonas gingivalis Gingipains Selectively Reduce CD14 Expression, Leading to Macrophage Hyporesponsiveness to Bacterial Infection.

    Authors:
    Wilensky A, Tzach-Nahman R, Potempa J, Shapira L, Nussbaum G.
    Status:
    Accepted for publication

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