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Information on the principal investigator and host institution

Information of the project and the call

Keywords

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Contribution of nitrergic transmission in the modulation of L-dopa activity in the rat 6-OHDA model of Parkinson's disease.

2011/01/B/NZ4/01581

Keywords:

Parkinson's disease therapy L-dopa nitric oxide molsidomine sildenafil phosphodiesterases cGMP 6-OHDA model rotational behavior dopamine metabolism

Descriptors:

  • NZ4_17:
  • NZ3_7: Signal transduction

Panel:

NZ4 - Biology of tissues, organs and organisms: morphology and functions of animal's and human's systems, organs and organisms, experimental medicine, basics of neurology

Host institution :

Instytut Farmakologii PAN

woj. małopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr hab. Elżbieta Lorenc-Koci 

Number of co-investigators in the project: 6

Call: OPUS 1 - announced on 2011-03-15

Amount awarded: 386 500 PLN

Project start date (Y-m-d): 2011-12-16

Project end date (Y-m-d): 2015-06-15

Project duration:: 42 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. Gilotyna (4 000 PLN)
  2. Aparat do elektroforezy białek (4 000 PLN)
  3. Termoblok (3 000 PLN)
  4. Aparat do transferu (10 000 PLN)
  5. Kołyska laboratoryjna.
  6. Dodatkowa końcówka dyspersyjna do homogenizatora ultradźwiękowego (1 500 PLN)

Information in the final report

  • Publication in academic press/journals (2)
  • Articles in post-conference publications (8)
  1. Contribution of the nitric oxide donor molsidomine and the antiparkinsonian drug L-DOPA to the modulation of the blood pressure in unilaterally 6-OHDA-lesioned rats
    Authors:
    E. Lorenc-Koci, A. Czarnecka, K. Kamińska, J. Knutelska, M. Zygmunt, M. Dudek
    Academic press:
    Pharmacological Reports (rok: 2017, tom: 69, strony: 29-35), Wydawca: Elsevier
    Status:
    Published
    DOI:
    brak - link to the publication
  2. The preferential nNOS inhibitor 7-nitroindazole and the non-selective one NG-nitro-L-arginine methyl ester administered alone or jointly with L-DOPA differentlly affect motor behavior and monoamine metabolism in sham-operated and 6-OHDA-lesioned rats
    Authors:
    A. Czarnecka, J. Konieczny, T. Lenda, E. Lorenc-Koci
    Academic press:
    Brain Research (rok: 2015, tom: 1625, strony: 218-237), Wydawca: Elsevier
    Status:
    Published
    DOI:
    brak - link to the publication
  1. NO donor and L-DOPA affect expression of proteins involved in the nitrergic signaling in brain dopaminergic structures of 6-OHDA-lesioned rats.
    Authors:
    Lorenc-Koci E, Czarnecka A, Lenda T, Kamińska K, Konieczny J.
    Conference:
    9th FENS FORUM OF NEUROSCIENCE, (rok: 2014, ), Wydawca: organizator konferencji
    Data:
    konferencja July 5-9, 2014, Milan, Italy
    Status:
    Published
  2. Chronic treatment with a nitric oxide donor, molsidomine and L-DOPA, alone or in combination, differently affect cGMP concentration in the striatum of unilaterally 6-OHDA-lesioned rats.
    Authors:
    Lenda T, Kmieć I, Kamińska K, Czarnecka A, Konieczny J, Lorenc-Koci E
    Conference:
    The 12th International Symposium "MOLECULAR BASIS OF PATHOLOGY AND THERAPY IN NEUROLOGICAL DISORDERS" (rok: 2014, ), Wydawca: Termedia Publishing House
    Data:
    konferencja November 20-21, 2014, Warsaw, Poland.
    Status:
    Published
  3. Sildenafil, an inhibitor of phosphodiesterase 5 (PDE5), affects asymetric behawior and monoamine metabolism in unilaterally 6-OHDA-lesioned rats treated chronically with L-DOPA.
    Authors:
    Kmieć I, Lenda T, Kamińska K, Czarnecka A, Lorenc-Koci E
    Conference:
    The 12th International Symposium "MOLECULAR BASIS OF PATHOLOGY AND THERAPY IN NEUROLOGICAL DISORDERS" (rok: 2014, ), Wydawca: Termedia Publishin House
    Data:
    konferencja November 20-21, 2014, Warsaw, Poland
    Status:
    Published
    DOI:
    link to the publication
  4. The influence of the selective nNOS inhibitor 7-nitroindazole on rotational behavior and and dopamine metabolism in 6-OHDA-lesioned rats treated chronically with L-dopa.
    Authors:
    Lorenc-Koci E., Czarnecka A., Lenda T., Konieczny J
    Conference:
    7th International Conference on the Biology, Chemistry and Therapeutic Application of Nitric Oxide, (rok: 2012, ), Wydawca: Elsevier
    Data:
    konferencja Edinburgh, Scotland, 22-26 July, 2012
    Status:
    Published
  5. Nitric oxide modulates rotational behaviour: a comparison between selective D1, D2 receptor agonists and L-DOPA in a rat model of Parkinson's disease.
    Authors:
    Czarnecka A, Lenda T, Konieczny J, Kamińska K, Lorenc-Koci E
    Conference:
    DOPAMINE 2013 (rok: 2013, ), Wydawca: organizator konferencji
    Data:
    konferencja DOPAMINE 2013, May 23-28, Alghero, Italy
    Status:
    Published
  6. The effect of the non-selective nitric oxide synthase inhibitor L-NAME on rotational behavior and dopamine metabolism in 6-OHDA-lesioned rats treated chronically with L-dopa.
    Authors:
    Czarnecka A, Lenda T, Konieczny J, Lorenc-Koci E
    Conference:
    7th International Conference on the Biology, Chemistry and Therapeutic Application of Nitric Oxide, (rok: 2012, ), Wydawca: Elsevier
    Data:
    konferencja Edinburgh, Scotland, 22-26 July, 2012
    Status:
    Published
  7. Effects of dopamine receptors agonists on expression of proteins involved in the nitrergic signaling in brain dopaminergic structures of 6-OHDA-lesioned rats
    Authors:
    Lenda T, Czarnecka A, Kamińska K, Konieczny J, Lorenc-Koci E
    Conference:
    9th FENS FORUM OF NEUROSCIENCE (rok: 2014, ), Wydawca: organizator konferencji
    Data:
    konferencja July 5-9, 2014, Milan, Italy
    Status:
    Published
  8. Impact of nitric oxide synthase inhibitors on rotational behaviour and dopamine metabolism in 6-OHDA-lesioned rats receiving L-DOPA.
    Authors:
    Czarnecka A, Lenda T, Konieczny J, Lorenc-Koci E
    Conference:
    25th ECNP Congress (rok: 2012, ), Wydawca: Elsevier
    Data:
    konferencja October 13-17, 2012, Vienna, Austria
    Status:
    Published

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