Projects funded by the NCN


Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Evaluation of the protective capacity of resveratrol and quercetin in models of neurotoxicity induced by aluminum and manganese

2011/01/B/NZ4/00708

Keywords:

neurotoxicity neuroprotection metals natural polyphenols aluminum manganese resveratrol quercetin wine

Descriptors:

  • NZ4_16:
  • NZ4_17:
  • NZ4_18:

Panel:

NZ4 - Biology of tissues, organs and organisms: morphology and functions of animal's and human's systems, organs and organisms, experimental medicine, basics of neurology

Host institution :

Uniwersytet Jagielloński - Collegium Medicum, Collegium Medicum, Wydział Farmaceutyczny

woj. małopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Maciej Gawlik 

Number of co-investigators in the project: 6

Call: OPUS 1 - announced on 2011-03-15

Amount awarded: 349 608 PLN

Project start date (Y-m-d): 2011-12-15

Project end date (Y-m-d): 2015-06-14

Project duration:: 42 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. Czytnik wielopłytykowy z dyspenserami M200 PRO (TECAN) (53 000 PLN)
  2. Lampa ksenonowa do detektora fluorescencyjnego RF-551 (SHIMADZU).
  3. Autosampler do chromatografu HPLC-F (THERMO Scientific).

Information in the final report

  • Publication in academic press/journals (4)
  • Articles in post-conference publications (4)
  1. Oxidative stress in neurodegenerative diseases
    Authors:
    Ewa Niedzielska, Irena Smaga , Maciej Gawlik, Andrzej Moniczewski, Piotr Stankowicz, Joanna Pera, Małgorzata Filip
    Academic press:
    Molecular Neurobiology (rok: 2016, tom: 53, strony: 4094-125), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s12035-015-9337-5 - link to the publication
  2. Oxidative stress as an etiological factor and a potential treatment target of psychiatric disorders. Part 2. Depression, anxiety, schizophrenia and autism
    Authors:
    Irena Smaga, Ewa Niedzielska, Maciej Gawlik, Andrzej Moniczewski, Jan Krzek, Edmund Przegaliński, Joanna Pera, Małgorzata Filip
    Academic press:
    Pharmacological Reports (rok: 2015, tom: 67, strony: 569-580), Wydawca: ELSEVIER
    Status:
    Published
    DOI:
    10.1016/j.pharep.2014.12.015 - link to the publication
  3. Oxidative stress as an etiological factor and a potential treatment target of psychiatric disorders. Part 1. Chemical aspects and biological sources of oxidative stress in the brain
    Authors:
    Andrzej Moniczewski, Maciej Gawlik, Irena Smaga, Ewa Niedzielska, Jan Krzek, Edmund Przegaliński, Joanna Pera, Małgorzata Filip
    Academic press:
    Pharmacological Reports (rok: 2015, tom: 67, strony: 560-568), Wydawca: ELSEVIER
    Status:
    Published
    DOI:
    10.1016/j.pharep.2014.12.014 - link to the publication
  4. Manganese neurotoxicity and protective effects of resveratrol and quercetin in preclinical research
    Authors:
    Maciej Gawlik , Małgorzata B. Gawlik , Irena Smaga , Małgorzata Filip
    Academic press:
    Pharmacological Reports , Wydawca: Elsevier
    Status:
    Submitted
  1. The use of SH-SY5Y neuroblastoma cell line in an valuation of protective effect of polyphenols in aluminum- and manganese-induced cytotoxicity models
    Authors:
    Katarzyna Chamera, Maciej Gawlik, Beata Starek-Świechowicz, Bogusława Budziszewska
    Conference:
    Analytical methods to study oxidative damage, antioxidants and drugs (rok: 2015, ), Wydawca: Wydawnictwo Uniwersytetu w Białymstoku
    Data:
    konferencja 4-7 czerwca
    Status:
    Published
  2. AMBIVALENT EFFECTS OF MANGANESE IN THE SUBACUTE EXPOSURE COMBINED WITH ETHANOL IN THE MODEL OF PROTECTIVE ACTIVITY OF RESVERATROL AND QUERCETIN IN RATS
    Authors:
    Maciej Gawlik, Małgorzata Gawlik
    Conference:
    I International Conference on Pharmaceutical and Medical Sciences (rok: 2016, ), Wydawca: ZOZ Ośrodek UMEA SHINODA-KURACEJO
    Data:
    konferencja 22-24.07.2016
    Status:
    Published
  3. Zmiany wybranych parametrów równowagi pro-/antyoksydacyjnej w izolowanych strukturach mózgu szczura w modelu neuroprotekcji rezweratrolu i kwercetyny w zawodowym narażeniu na mangan i glin
    Authors:
    Maciej Gawlik, Małgorzata Gawlik, Małgorzata Filip
    Conference:
    Konferencja szkoleniowo-naukowa Polskiego Towarzystwa Toksykologicznego. Człowiek, żywność, środowisko - problemy współczesnej toksykologii (rok: 2014, ), Wydawca: Wydawnictwo Uniwersytetu Warmińsko-Mazurskiego w Olsztynie
    Data:
    konferencja 16-19 września
    Status:
    Published
  4. EFFECTS OF RESVERATROL AND QUERCRTIN ON THE GSH AND GSSG BRAIN LEVELS DURING OCCUPATIONAL EXPOSURE TO MANGANESE IN RATS
    Authors:
    Maciej Gawlik, Małgorzata Gawlik, Małgorzata Filip
    Conference:
    7th ISANH Congress on Polyphenols Applications (rok: 2013, ), Wydawca: ISANH
    Data:
    konferencja 6-7 czerwca
    Status:
    Published