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The role of stearoyl-CoA desaturase in pathogenesis of myocardial hypertrophy

2011/01/D/NZ3/04777

Keywords

Descriptors

  • NZ3_1: Biologia komórki
  • NZ3_2: Fizjologia komórki

Panel

NZ3 – Cellular and developmental biology: cell biology, developmental biology, ageing biology, neurobiology

Host institution

Instytut Biologii Doświadczalnej im. M. Nenckiego PAN

Voivodeship: mazowieckie

Other projects carried out by the institution »

Principal investigator (from the host institution)

dr hab. Paweł Dobrzyń

Number of co-investigators in the project: 6

Call

SONATA 1 – announced on 2011-03-15

Amount awarded
600 000 PLN
Project start date
2011-12-07
Project end date
2015-06-06
Project duration
42 months (the same as in the proposal)
Project status
Project settled

Equipment purchased [PL]

  1. Mikroskop odwrócony.
  2. Termocykler. Cost: 30 000 PLN
  3. Wirówka z chłodzeniem oraz zestawem rotorów. Cost: 25 000 PLN
  4. Zestaw do elektroforezy pionowej, poziomej oraz do transferu białek. Cost: 25 000 PLN

Information in the final report

Publication in academic press/journals (5)

  1. Stearoyl-CoA desaturase regulates inflammatory gene expression by changing DNA methylation level in 3T3 adipocytes

    Authors:
    Małgorzata Małodobra-Mazur, Anna Dziewulaska, Kamil Koziński, Paweł Dobrzyń, Katarzyna Kolczyńska, Justyna Janikiewicz, Agnieszka Dobrzyń
    Academic press:
    International Journal of Biochemistry and Cell Biology (year: 2014, volume: 55, pages: 40-50), Publisher: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.biocel.2014.08.005 – link to the publication

  2. Rola desaturazy staroilo-CoA w utrzymaniu homeostazy metabolicznej

    Authors:
    Paweł Dobrzyń
    Academic press:
    Postępy Biochemii (year: 2012, volume: 58, pages: 166-174), Publisher: Polskie Towarzystwo Biochemiczne
    Status:
    Published

  3. Expression of lipogenic genes is upregulated in the heart with exercise training-induced but not pressure overload-induced left ventricular hypertrophy

    Authors:
    Paweł Dobrzyń, Aleksandra Pyrkowska, Monika Duda, Tomasz Bednarski, Michał Maczewski, Józef Langfort, Agnieszka Dobrzyń
    Academic press:
    American Journal of Physiology - Endocrinology and Metabolism (year: 2013, volume: 304, pages: E1384-E1358), Publisher: American Physiological Society
    Status:
    Published
    DOI:
    10.1152/ajpendo.00603.2012 – link to the publication

  4. Metabolic reprogramming of the heart through stearoyl-CoA desaturase

    Authors:
    Paweł Dobrzyń, Tomasz Bednarski, Agnieszka Dobrzyń
    Academic press:
    Progress in Lipid Research (year: 2015, volume: 57, pages: 46034), Publisher: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.plipres.2014.11.003 – link to the publication

  5. Białkowe czynniki lipogenne – rola w regulacji metabolizmu i funkcji mięśnia sercowego

    Authors:
    Tomasz Bednarski, Aleksandra Pyrkowska, Agnieszka Opasińska, Paweł Dobrzyń
    Status:
    Accepted for publication

Articles in post-conference publications (9)

  1. Lipid metabolizm in different types of left ventricular hypertrophy

    Authors:
    Tomasz Bednarski, Aleksandra Pyrkowska, Anna Ochałek, Monika Duda, Agnieszka Dobrzyń, Józef Langfort, Paweł Dobrzyń
    Conference:
    54th International Conference on the Bioscience of Lipids (year: 2013, pages: 5), Publisher: International Conference on the Bioscience of Lipids
    Date:
    conference 17-21 wrzesień
    Status:
    Published

  2. Hypertension-induced heart steatosis is not associated with increased cardiac lipogenesis

    Authors:
    Tomasz Bednarski, Adam Olichwier, Agnieszka Opasińska, Paweł Dobrzyń
    Conference:
    BIO 2014 (year: 2014, pages: 220), Publisher: Polskie Towarzystwo Biochemiczne
    Date:
    conference 9-12 wrzesień
    Status:
    Published

  3. Stearoyl-CoA desaturase expression is upregulated in exercise training-induced left ventricular hypertrophy

    Authors:
    Paweł Dobrzyń, Aleksandra Pyrkowska, Tomasz Bednarski, Anna Ochałek, Monika Duda, Józef Langfort, Agnieszka Dobrzyń
    Conference:
    38th FEBS Congress (year: 2013, pages: 182), Publisher: The Federation of European Biochemical Societies
    Date:
    conference 6-11 lipiec 2013
    Status:
    Published

  4. Effect of dietary stearate and oleate on expression of fatty acid desaturases and elongases in the heart

    Authors:
    T. Bednarski, M. Jazurek, A. Dobrzyń, M. Małodobra-Mazur, P. Dobrzyń
    Conference:
    10th Euro Fed Lipid Congress, Kraków 2012 (year: 2012, pages: 357), Publisher: 10th Euro Fed Lipid Congress
    Date:
    conference 23-26 wrzesień
    Status:
    Published

  5. Monounsaturated fatty acids activate lipogenic pathways in the heart leading to cardiac steatosis and left ventricular remodeling

    Authors:
    Tomasz Bednarski, Aleksandra Pyrkowska, Agnieszka Dobrzyń, Monika Duda, Paweł Dobrzyń
    Conference:
    48th Annual Scientific Meeting of European Society for Clinical Investigation (year: 2014, pages: 7), Publisher: European Society for Clinical Investigation
    Date:
    conference 30 kwiecień - 3 maj
    Status:
    Published

  6. Overexpression of lipogenic genes in the heart didtinguishes physiologic from pathologic left ventricle hypertrophy

    Authors:
    Paweł Dobrzyń, Aleksandra Pyrkowska, Monika Duda, Michał Maczewski, Tomasz Bednarski, Józef Langfort, Agnieszka Dobrzyń
    Conference:
    Experimental Biology (year: 2013, pages: 813,2), Publisher: Federation of American Societies for Experimental Biology
    Date:
    conference 20-24 kwiecień
    Status:
    Published
    DOI:
    link to the publication

  7. Cardiac lipid metabolism – the role of stearoyl-CoA desaturase-4

    Authors:
    Anna Ochałek, Paweł Dobrzyń
    Conference:
    1st Nencki Institute PhD Student Conference (year: 2013, pages: 53), Publisher: Instytut Biologii Doświadczalnej PAN
    Date:
    conference 16-18 październik
    Status:
    Published

  8. Lipid-induced cardiac remodeling and left ventricle steatosis depend on the degree of saturation of fatty acids in dietary fats

    Authors:
    Paweł Dobrzyń, Tomasz Bednarski, Agnieszka Dobrzyń, Monika Duda, Aleksandra Pyrkowska
    Conference:
    The 11th Biennial International Society for the Study of Fatty Acids and Lipids Congress 2014 (year: 2014, pages: S5.01), Publisher: International Society for the Study of Fatty Acods and Lipids
    Date:
    conference 28 czerwiec - 2 lipiec
    Status:
    Published
    DOI:
    link to the publication

  9. Activity of AMPK/mTOR pathway depends on type and time of hypertensive stimuli in the heart

    Authors:
    Tomasz Bednarski, Monika Duda, Paweł Dobrzyń
    Conference:
    40th FEBS Congress (year: 2015, pages: 222), Publisher: The Federation of European Biochemical Societes
    Date:
    conference 4-9 lipiec
    Status:
    Published

Book publications / chapters in book publications (1)

  1. Stearoyl-CoA desaturase in the control of heart metabolism

    Authors:
    Paweł Dobrzyń, Agnieszka Dobrzyń
    Book:
    Stearoyl-CoA desaturase genes in lipid metabolism (year: 2013, volume: nie dotyczy, pages: 85-101), Publisher: Springer
    Status:
    Published

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