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VDAC channel as a target of huntingtin in the etiology of Huntington's disease

2011/01/B/NZ3/00359

Keywords

Descriptors

  • NZ3_1: Biologia komórki
  • NZ3_6: Neurobiologia komórkowa

Panel

NZ3 – Cellular and developmental biology: cell biology, developmental biology, ageing biology, neurobiology

Host institution

Uniwersytet im. Adama Mickiewicza w Poznaniu, Wydział Biologii

Voivodeship: wielkopolskie

Other projects carried out by the institution »

Principal investigator (from the host institution)

prof. Hanna Małgorzata Kmita

Number of co-investigators in the project: 7

Call

OPUS 1 – announced on 2011-03-15

Amount awarded
377 500 PLN
Project start date
2011-12-07
Project end date
2015-12-06
Project duration
48 months (the same as in the proposal)
Project status
Project settled

Equipment purchased [PL]

  1. Mikrowirówka z chłodzeniem MPW65R. Cost: 14 000 PLN
  2. System oksygraficzny z dwoma elektrodami tlenowymi (Hansatech) i komputer. Cost: 23 000 PLN
  3. Termomikser z funkcją grzania, chłodzenia i mieszania typu comfort (Eppendorf). Cost: 13 000 PLN
  4. Zestaw do elektroforezy i transferu półsuchego: aparat do elektroforezy (MEDIUM) i transferu półsuchego (Sedryt Large) - Kucharczyk/ ZAKUP PRZESUNIĘTO NA 2013. Cost: 9 000 PLN

Information in the final report

Publication in academic press/journals (2)

  1. VDAC as a potential target in Huntington's disease therapy: the state of the art.

    Authors:
    Andonis Karachitos, Daria Grobys, Hanna Kmita
    Academic press:
    Pharmaceutical Regulatory Affairs: Open Access (year: 2015, volume: 4, pages: 157), Publisher: Omics Publishing/Pharma Group
    Status:
    Published
    DOI:
    10.4172/2167-7689.1000157 – link to the publication

  2. Effect of plant extracts antioxidative phenolic compounds on energetic status and viability of Saccharomyces cerevisiae cells undergoing the oxidative stress

    Authors:
    Justyna Chanaj-Kaczmarek, Michał Wysocki, Andonis Karachitos, Małgorzata Wojcińska, Grzegorz Bartosz, Irena Matławska, Hanna Kmita
    Academic press:
    Journal of Functional Foods (year: 2015, volume: 16, pages: 364-377), Publisher: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.jff.2015.04.046 – link to the publication

Articles in post-conference publications (10)

  1. Effects of cell division activity, mitochondrial energy status and inhibition of mitochondrial fission on cell viability and distribution of native and mutant version of huntingtin in rat tissue culture model of Huntington's disease (PC12 cells).

    Authors:
    Grobys D., Karachitos A., Skrzypczak T., Kmita H
    Conference:
    18th European Bioenergetics Conference (EBEC) (year: 2014, pages: e27), Publisher: Biochimica et Biophysica Acta (BBA) - Bioenergetics, Elsevier
    Date:
    conference 12 - 17 lipiec
    Status:
    Published
    DOI:
    link to the publication

  2. Cell viability and distribution of huntingtin in PC12 model of Huntington disease under conditions affecting cell division, mitochondrial bioenergetics and mitochondrial dynamics.

    Authors:
    Grobys D., Karachitos A., Skrzypczak T., Kmita H.
    Conference:
    1st Congress of the Polish Biochemistry, Cell Biology, Biophysics and Bioinformatics (year: 2014, pages: 274), Publisher: Acta Biochimica Polonica
    Date:
    conference 9 - 12 wrzesień
    Status:
    Published
    DOI:
    link to the publication

  3. Do native and mutated forms of huntingtin interact with human VDAC isoforms? Wykład

    Authors:
    Karachitos A., Grobys D., Stobienia O., Sobczak K., De Pinto V., Kmita H.
    Conference:
    1st Congress of the Polish Biochemistry, Cell Biology, Biophysics and Bioinformatics (year: 2014, pages: 268), Publisher: Acta Biochimica Polonica
    Date:
    conference 9 - 12 wrzesień
    Status:
    Published
    DOI:
    link to the publication

  4. Do native and mutated forms of huntingtin distinguish human VDAC isoforms?

    Authors:
    Karachitos A., Stobienia O., Sobczak K., De Pinto V., Kmita H.
    Conference:
    18th European Bioenergetics Conference (EBEC) (year: 2014, pages: e109), Publisher: Biochimica et Biophysica Acta (BBA) - Bioenergetics, Elsevier
    Date:
    conference 12 - 17 lipiec
    Status:
    Published
    DOI:
    link to the publication

  5. The therapeutic potential of voltage dependent anionselective channel: implications for Huntington disease. Wykład

    Authors:
    Karachitos A., Grobys D., Zając G., Sobcza K., de Pinto V., Kmita H
    Conference:
    48th Congress of the Polish Biochemical Society (year: 2013, pages: 130), Publisher: Acta Biochem. Pol. Suppl. 1, 2013
    Date:
    conference 2-5 wrzesień
    Status:
    Published
    DOI:
    link to the publication

  6. Effects of cell metabolic state, cell division activity and inhibition of mitochondrial fission on expression of native and mutant version of huntingtin in rat tissue culture model of Huntington's disease.

    Authors:
    Grobys D., Skrzypczak T., Karachitos A., Kmita H
    Conference:
    III Konferencja Naukowo-Dydaktyczna Wydziału Biologii UAM (year: 2014, pages: 71), Publisher: wydawnictwo Kontekst
    Date:
    conference 10-12 kwiecień
    Status:
    Published

  7. Changes of mitochondrial functional states in rat tissue culture model of Huntington's disease triggered by native and mutated version of huntingtin.

    Authors:
    Kulczyńska K, Grobys D., Karachitos A., Kmita H.
    Conference:
    III Konferencja Naukowo-Dydaktyczna Wydziału Biologii UAM (year: 2014, pages: 100-101), Publisher: wydawnictwo Kontekst
    Date:
    conference 10-12 kwiecień
    Status:
    Published

  8. The yeast model of Huntingtin disease in studies concerning the role of human VDAC isoforms in the disease pathomechanism

    Authors:
    D. Grobys, A. Karachitos, H. Kmita
    Conference:
    40th FEBS Congress - The biochemical basis of life (year: 2015, pages: 175), Publisher: Wiley Online Library
    Date:
    conference 4 - 9 lipiec
    Status:
    Published
    DOI:
    link to the publication

  9. VDAC activity in the presence of huntingtin proteins

    Authors:
    A. Karachitos, D. Grobys, V. De Pinto, H. Kmita
    Conference:
    40th FEBS Congress - The biochemical basis of life (year: 2015, pages: 322), Publisher: Wiley Online Library
    Date:
    conference 4 - 9 lipiec
    Status:
    Published
    DOI:
    link to the publication

  10. Measurements of VDAC conductance in the presence of huntingtin proteins.

    Authors:
    Karachitos A., Stobienia O., Sobczak K., De Pinto V., Kmita H
    Conference:
    1st Congress of the Polish Biochemistry, Cell Biology, Biophysics and Bioinformatics (year: 2014, pages: 275), Publisher: Acta Biochimica Polonica
    Date:
    conference 9 - 12 wrzesień
    Status:
    Published
    DOI:
    link to the publication

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